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Brief Title: Study to Assess the Efficacy and Safety of Ublituximab + Umbralisib With or Without Bendamustine and Umbralisib Alone in Patients With Previously Treated Non-Hodgkins Lymphoma
Official Title: A Phase 2b Randomized Study to Assess the Efficacy and Safety of the Combination of Ublituximab + Umbralisib With or Without Bendamustine and Umbralisib Alone in Patients With Previously Treated Non-Hodgkin's Lymphoma
Study ID: NCT02793583
Brief Summary: Unity NHL - A Phase 2b Randomized Study to Assess the Efficacy and Safety of the Combination of Ublituximab + Umbralisib with or without Bendamustine and Umbralisib alone in Patients with Previously Treated Non-Hodgkin's Lymphoma
Detailed Description: The purpose of this study is to evaluate the efficacy and safety of umbralisib monotherapy and the umbralisib + ublituximab (U2) combination in aggressive and indolent lymphomas and to also explore the U2 regimen in combination with bendamustine in the treatment of NHL (FL, SLL, MZL, DLBCL and MCL).
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
TG Therapeutics Investigational Trial Site, Birmingham, Alabama, United States
TG Therapeutics Investigational Trial Site, Huntsville, Alabama, United States
TG Therapeutics Investigational Trial Site, Chandler, Arizona, United States
TG Therapeutics Investigational Trial Site, Tucson, Arizona, United States
TG Therapeutics Investigational Trial Site, Tucson, Arizona, United States
TG Therapeutics Investigational Trial Site, Los Angeles, California, United States
TG Therapeutics Investigational Trial Site, Orange, California, United States
TG Therapeutics Investigational Trial Site, San Diego, California, United States
TG Therapeutics Investigational Trial Site, San Diego, California, United States
TG Therapeutics Investigational Trial Site, Whittier, California, United States
TG Therapeutics Investigational Trial Site, Aurora, Colorado, United States
TG Therapeutics Investigational Trial Site, Denver, Colorado, United States
TG Therapeutics Investigational Trial Site, Fort Collins, Colorado, United States
TG Therapeutics Investigational Trial Site, Bridgeport, Connecticut, United States
TG Therapeutics Investigational Trial Site, Newark, Delaware, United States
TG Therapeutics Investigational Trial Site, Washington, District of Columbia, United States
TG Therapeutics Investigational Trial Site, Boca Raton, Florida, United States
TG Therapeutics Investigational Trial Site, Fort Myers, Florida, United States
TG Therapeutics Investigational Trial Site, Gainesville, Florida, United States
TG Therapeutics Investigational Trial Site, Jacksonville, Florida, United States
TG Therapeutics Investigational Trial Site, Jacksonville, Florida, United States
TG Therapeutics Investigational Trial Site, Jacksonville, Florida, United States
TG Therapeutics Investigational Trial Site, Miami, Florida, United States
TG Therapeutics Investigational Trial Site, Saint Petersburg, Florida, United States
TG Therapeutics Investigational Trial Site, Tallahassee, Florida, United States
TG Therapeutics Investigational Trial Site, Tampa, Florida, United States
TG Therapeutics Investigational Trial Site, West Palm Beach, Florida, United States
TG Therapeutics Investigational Trial Site, Albany, Georgia, United States
TG Therapeutics Investigational Trial Site, Macon, Georgia, United States
TG Therapeutics Investigational Trial Site, Marietta, Georgia, United States
TG Therapeutics Investigational Trial Site, Chicago, Illinois, United States
TG Therapeutics Investigational Trial Site, Chicago, Illinois, United States
TG Therapeutics Investigational Trial Site, Decatur, Illinois, United States
TG Therapeutics Investigational Trial Site, Evanston, Illinois, United States
TG Therapeutics Investigational Trial Site, Harvey, Illinois, United States
TG Therapeutics Investigational Trial Site, Maywood, Illinois, United States
TG Therapeutics Investigational Trial Site, Niles, Illinois, United States
TG Therapeutics Investigational Trial Site, Peoria, Illinois, United States
TG Therapeutics Investigational Trial Site, Swansea, Illinois, United States
TG Therapeutics Investigational Trial Site, Fort Wayne, Indiana, United States
TG Therapeutics Investigational Trial Site, Indianapolis, Indiana, United States
TG Therapeutics Investigational Trial Site, Westwood, Kansas, United States
TG Therapeutics Investigational Trial Site, Louisville, Kentucky, United States
TG Therapeutics Investigational Trial Site, Covington, Louisiana, United States
TG Therapeutics Investigational Trial Site, Brewer, Maine, United States
TG Therapeutics Investigational Trial Site, Baltimore, Maryland, United States
TG Therapeutics Investigational Trial Site, Bethesda, Maryland, United States
TG Therapeutics Investigational Trial Site, Columbia, Maryland, United States
TG Therapeutics Investigational Trial Site, Towson, Maryland, United States
TG Therapeutics Investigational Trial Site, Ann Arbor, Michigan, United States
TG Therapeutics Investigational Trial Site, Duluth, Minnesota, United States
TG Therapeutics Investigational Trial Site, Saint Louis Park, Minnesota, United States
TG Therapeutics Investigational Trial Site, Columbia, Missouri, United States
TG Therapeutics Investigational Trial Site, Kansas City, Missouri, United States
TG Therapeutics Investigational Trial Site, Saint Louis, Missouri, United States
TG Therapeutics Investigational Trial Site, Billings, Montana, United States
TG Therapeutics Investigational Trial Site, Lincoln, Nebraska, United States
TG Therapeutics Investigational Trial Site, Omaha, Nebraska, United States
TG Therapeutics Investigational Trial Site, Lebanon, New Hampshire, United States
TG Therapeutics Investigational Trial Site, Hackensack, New Jersey, United States
TG Therapeutics Investigational Trial Site, Morristown, New Jersey, United States
TG Therapeutics Investigational Trial Site, Mount Holly, New Jersey, United States
TG Therapeutics Investigational Trial Site, Farmington, New Mexico, United States
TG Therapeutics Investigational Trial Site, Bronx, New York, United States
TG Therapeutics Investigational Trial Site, Buffalo, New York, United States
TG Therapeutics Investigational Trial Site, New York, New York, United States
TG Therapeutics Investigational Trial Site, Syracuse, New York, United States
TG Therapeutics Investigational Trial Site, Charlotte, North Carolina, United States
TG Therapeutics Investigational Trial Site, Durham, North Carolina, United States
TG Therapeutics Investigational Trial Site, Hickory, North Carolina, United States
TG Therapeutics Investigational Trial Site, Kinston, North Carolina, United States
TG Therapeutics Investigational Trial Site, Raleigh, North Carolina, United States
TG Therapeutics Investigational Trial Site, Washington, North Carolina, United States
TG Therapeutics Investigational Trial Site, Canton, Ohio, United States
TG Therapeutics Investigational Trial Site, Cincinnati, Ohio, United States
TG Therapeutics Investigational Trial Site, Cincinnati, Ohio, United States
TG Therapeutics Investigational Trial Site, Cleveland, Ohio, United States
TG Therapeutics Investigational Trial Site, Columbus, Ohio, United States
TG Therapeutics Investigational Trial Site, Toledo, Ohio, United States
TG Therapeutics Investigational Trial Site, Portland, Oregon, United States
TG Therapeutics Investigational Trial Site, Portland, Oregon, United States
TG Therapeutics Investigational Trial Site, Springfield, Oregon, United States
TG Therapeutics Investigational Trial Site, Camp Hill, Pennsylvania, United States
TG Therapeutics Investigational Trial Site, Philadelphia, Pennsylvania, United States
TG Therapeutics Investigational Trial Site, Providence, Rhode Island, United States
TG Therapeutics Investigational Trial Site, Greenville, South Carolina, United States
TG Therapeutics Investigational Trial Site, Sioux Falls, South Dakota, United States
TG Therapeutics Investigational Trial Site, Watertown, South Dakota, United States
TG Therapeutics Investigational Trial Site, Chattanooga, Tennessee, United States
TG Therapeutics Investigational Trial Site, Kingsport, Tennessee, United States
TG Therapeutics Investigational Trial Site, Knoxville, Tennessee, United States
TG Therapeutics Investigational Trial Site, Memphis, Tennessee, United States
TG Therapeutics Investigational Trial Site, Austin, Texas, United States
TG Therapeutics Investigational Trial Site, Dallas, Texas, United States
TG Therapeutics Investigational Trial Site, Fort Sam Houston, Texas, United States
TG Therapeutics Investigational Trial Site, Houston, Texas, United States
TG Therapeutics Investigational Trial Site, San Antonio, Texas, United States
TG Therapeutics Investigational Trial Site, San Antonio, Texas, United States
TG Therapeutics Investigational Trial Site, San Antonio, Texas, United States
TG Therapeutics Investigational Trial Site, Tyler, Texas, United States
TG Therapeutics Investigational Trial Site, Ogden, Utah, United States
TG Therapeutics Investigational Trial Site, Blacksburg, Virginia, United States
TG Therapeutics Investigational Trial Site, Newport News, Virginia, United States
TG Therapeutics Investigational Trial Site, Olympia, Washington, United States
TG Therapeutics Investigational Trial Site, Seattle, Washington, United States
TG Therapeutics Investigational Trial Site, Seattle, Washington, United States
TG Therapeutics Investigational Trial Site, Seattle, Washington, United States
TG Therapeutics Investigational Trial Site, Spokane, Washington, United States
TG Therapeutics Investigational Trial Site, Vancouver, Washington, United States
TG Therapeutics Investigational Trial Site, Madison, Wisconsin, United States
TG Therapeutics Investigational Trial Site, Wauwatosa, Wisconsin, United States
TG Therapeutics Investigational Trial Site, Gosford, New South Wales, Australia
TG Therapeutics Investigational Trial Site, Wahroonga, New South Wales, Australia
TG Therapeutics Investigational Trial Site, Benowa, Queensland, Australia
TG Therapeutics Investigational Trial Site, South Brisbane, Queensland, Australia
TG Therapeutics Investigational Trial Site, Adelaide, South Australia, Australia
TG Therapeutics Investigational Trial Site, Heidelberg, Victoria, Australia
TG Therapeutics Investigational Trial Site, Nedlands, Western Australia, Australia
TG Therapeutics Investigational Trial Site, Netherlands, Western Australia, Australia
TG Therapeutics Investigational Trial Site, Gosford, , Australia
TG Therapeutics Investigational Trial Site, Ashkelon, , Israel
TG Therapeutics Investigational Trial Site, Be'er Sheva, , Israel
TG Therapeutics Investigational Trial Site, Haifa, , Israel
TG Therapeutics Investigational Trial Site, Jerusalem, , Israel
TG Therapeutics Investigational Trial Site, Nahariya, , Israel
TG Therapeutics Investigational Trial Site, Petah Tikva, , Israel
TG Therapeutics Investigational Trial Site, Tel Aviv, , Israel
TG Therapeutics Investigational Trial Site, Tel Aviv, , Israel
TG Therapeutics Investigational Trial Site, Bologna, , Italy
TG Therapeutics Investigational Trial Site, Ferrara, , Italy
TG Therapeutics Investigational Trial Site, Milan, , Italy
TG Therapeutics Investigational Trial Site, Milan, , Italy
TG Therapeutics Investigational Trial Site, Rome, , Italy
TG Therapeutics Investigational Trial Site, Torino, , Italy
TG Therapeutics Investigational Trial Site, Busan, , Korea, Republic of
TG Therapeutics Investigational Trial Site, Busan, , Korea, Republic of
TG Therapeutics Investigational Trial Site, Gyeonggi-do, , Korea, Republic of
TG Therapeutics Investigational Trial Site, Incheon, , Korea, Republic of
TG Therapeutics Investigational Trial Site, Seoul, , Korea, Republic of
TG Therapeutics Investigational Trial Site, Seoul, , Korea, Republic of
TG Therapeutics Investigational Trial Site, Seoul, , Korea, Republic of
TG Therapeutics Investigational Trial Site, Chorz贸w, , Poland
TG Therapeutics Investigational Trial Site, Gdynia, , Poland
TG Therapeutics Investigational Trial Site, Krak贸w, , Poland
TG Therapeutics Investigational Trial Site, Lublin, , Poland
TG Therapeutics Investigational Trial Site, S艂upsk, , Poland
TG Therapeutics Investigational Trial Site, Warszawa, , Poland
TG Therapeutics Investigational Trial Site, Warszawa, , Poland
TG Therapeutics Investigational Trial Site, Wroc艂aw, , Poland
TG Therapeutics Investigational Trial Site, 艁贸d藕, , Poland
TG Therapeutics Investigational Trial Site, Bratislava, , Slovakia
TG Therapeutics Investigational Trial Site, Bratislava, , Slovakia
TG Therapeutics Investigational Trial Site, Ko拧ice, , Slovakia
TG Therapeutics Investigational Trial Site, Poprad, , Slovakia
TG Therapeutics Investigational Trial Site, Barcelona, , Spain
TG Therapeutics Investigational Trial Site, Barcelona, , Spain
TG Therapeutics Investigational Trial Site, Madrid, , Spain
TG Therapeutics Investigational Trial Site, Madrid, , Spain
TG Therapeutics Investigational Trial Site, Salisbury, , Spain
TG Therapeutics Investigational Trial Site, Valencia, , Spain
TG Therapeutics Investigational Trial Site, Cambridge, , United Kingdom
TG Therapeutics Investigational Trial Site, Denmark Hill, , United Kingdom
TG Therapeutics Investigational Trial Site, Leeds, , United Kingdom
TG Therapeutics Investigational Trial Site, Liverpool, , United Kingdom
TG Therapeutics Investigational Trial Site, London, , United Kingdom
TG Therapeutics Investigational Trial Site, London, , United Kingdom
TG Therapeutics Investigational Trial Site, Oxford, , United Kingdom
TG Therapeutics Investigational Trial Site, Plymouth, , United Kingdom
Name: Owen A O'Connor, MD, PhD
Affiliation: Columbia University
Role: STUDY_CHAIR