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Spots Global Cancer Trial Database for Stereotactic Pelvic Adjuvant Radiation Therapy in Cancers of the Uterus II

The following info and data is provided "as is" to help patients around the globe.
We do not endorse or review these studies in any way.

Trial Identification

Brief Title: Stereotactic Pelvic Adjuvant Radiation Therapy in Cancers of the Uterus II

Official Title: Stereotactic Pelvic Adjuvant Radiation Therapy in Cancers of the Uterus II: A Phase II Randomized Controlled Trial

Study ID: NCT04890912

Study Description

Brief Summary: Adjuvant radiotherapy (RT) plays an important role in reducing the risks of local recurrence after surgery in uterine cancers. Standard adjuvant pelvic radiation treatment targets the pelvic lymph nodes, the post-operative bed, and the upper vagina and is typically treated with intensity modulated radiation therapy (IMRT) which has been shown to improve patient reported gastrointestinal (GI) and genitourinary (GU) toxicities. Although pelvic radiation has been shown to be effective at decreasing locoregional recurrences, patient quality of life and experience can be significantly impacted as pelvic RT comprises of daily radiation for 25 daily treatments, which can be a substantial burden on patients with this disease. Hypofractionated radiotherapy to a dose of 30 Gy in 5 fractions (6 Gy given every other day) for adjuvant radiation treatment in uterine cancer is hypothesized to result in similar rates of acute gastrointestinal toxicities as conventional fractionated radiation.

Detailed Description:

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: FEMALE

Healthy Volunteers: No

Locations

Royal Victoria Hospital, Barrie, Ontario, Canada

London Regional Cancer Program, London, Ontario, Canada

Credit Valley Hospital, Mississauga, Ontario, Canada

Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada

Princess Margaret Cancer Centre, Toronto, Ontario, Canada

Contact Details

Name: Eric Leung, MD

Affiliation: Sunnybrook Health Sciences Centre

Role: PRINCIPAL_INVESTIGATOR

Name: Kathy Han, MD

Affiliation: Princess Margaret Cancer Centre

Role: PRINCIPAL_INVESTIGATOR

Name: Adam Gladwish, MD

Affiliation: Royal Victoria Hospital

Role: PRINCIPAL_INVESTIGATOR

Useful links and downloads for this trial

Clinicaltrials.gov

Google Search Results

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