Spots Global Cancer Trial Database for Durvalumab With or Without Olaparib as Maintenance Therapy After First-Line Treatment of Advanced and Recurrent Endometrial Cancer
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Trial Identification
Brief Title: Durvalumab With or Without Olaparib as Maintenance Therapy After First-Line Treatment of Advanced and Recurrent Endometrial Cancer
Official Title: A Randomised, Multicentre, Double-blind, Placebo-controlled, Phase III Study of First-line Carboplatin and Paclitaxel in Combination With Durvalumab, Followed by Maintenance Durvalumab With or Without Olaparib in Patients With Newly Diagnosed Advanced or Recurrent Endometrial Cancer (DUO-E)
Study ID: NCT04269200
Conditions
Study Description
Brief Summary: A study to assess the efficacy and safety of durvalumab in combination with platinum-based chemotherapy (paclitaxel + carboplatin) followed by maintenance durvalumab with or without olaparib for patients with newly diagnosed advanced or recurrent endometrial cancer.
Detailed Description: This Phase III study will assess the efficacy and safety of durvalumab in combination with platinum-based chemotherapy (paclitaxel + carboplatin) followed by maintenance durvalumab with or without olaparib for patients with newly diagnosed advanced or recurrent endometrial cancer. Target patient population: Adult female patients with histologically confirmed diagnosis of epithelial endometrial carcinoma (excluding sarcomas): newly diagnosed Stage III, newly diagnosed Stage IV, or recurrent endometrial cancer
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: FEMALE
Healthy Volunteers: No
Locations
Research Site, Tucson, Arizona, United States
Research Site, Concord, California, United States
Research Site, La Jolla, California, United States
Research Site, San Francisco, California, United States
Research Site, Santa Barbara, California, United States
Research Site, Aurora, Colorado, United States
Research Site, Fort Lauderdale, Florida, United States
Research Site, Tampa, Florida, United States
Research Site, Savannah, Georgia, United States
Research Site, Honolulu, Hawaii, United States
Research Site, Arlington Heights, Illinois, United States
Research Site, Chicago, Illinois, United States
Research Site, Indianapolis, Indiana, United States
Research Site, Louisville, Kentucky, United States
Research Site, Baton Rouge, Louisiana, United States
Research Site, Boston, Massachusetts, United States
Research Site, Saint Paul, Minnesota, United States
Research Site, Jackson, Mississippi, United States
Research Site, Lebanon, New Hampshire, United States
Research Site, Camden, New Jersey, United States
Research Site, Paramus, New Jersey, United States
Research Site, New York, New York, United States
Research Site, New York, New York, United States
Research Site, Pinehurst, North Carolina, United States
Research Site, Cleveland, Ohio, United States
Research Site, Cleveland, Ohio, United States
Research Site, Dayton, Ohio, United States
Research Site, Oklahoma City, Oklahoma, United States
Research Site, Tulsa, Oklahoma, United States
Research Site, Eugene, Oregon, United States
Research Site, Tigard, Oregon, United States
Research Site, Pittsburgh, Pennsylvania, United States
Research Site, Providence, Rhode Island, United States
Research Site, Sioux Falls, South Dakota, United States
Research Site, Chattanooga, Tennessee, United States
Research Site, Germantown, Tennessee, United States
Research Site, Knoxville, Tennessee, United States
Research Site, Bedford, Texas, United States
Research Site, Dallas, Texas, United States
Research Site, Houston, Texas, United States
Research Site, San Antonio, Texas, United States
Research Site, Sugar Land, Texas, United States
Research Site, Tyler, Texas, United States
Research Site, Webster, Texas, United States
Research Site, Fairfax, Virginia, United States
Research Site, Norfolk, Virginia, United States
Research Site, Seattle, Washington, United States
Research Site, Morgantown, West Virginia, United States
Research Site, Madison, Wisconsin, United States
Research Site, Milwaukee, Wisconsin, United States
Research Site, Clayton, , Australia
Research Site, Malvern, , Australia
Research Site, Melbourne, , Australia
Research Site, Nedlands, , Australia
Research Site, Sydney, , Australia
Research Site, Bruges, , Belgium
Research Site, Bruxelles, , Belgium
Research Site, Charleroi, , Belgium
Research Site, Gent, , Belgium
Research Site, Hasselt, , Belgium
Research Site, Kortrijk, , Belgium
Research Site, Leuven, , Belgium
Research Site, Libramont-Chevigny, , Belgium
Research Site, Liège, , Belgium
Research Site, Belo Horizonte, , Brazil
Research Site, Belo Horizonte, , Brazil
Research Site, Curitiba, , Brazil
Research Site, Passo Fundo, , Brazil
Research Site, Pelotas, , Brazil
Research Site, Porto Alegre, , Brazil
Research Site, Porto Alegre, , Brazil
Research Site, Porto Alegre, , Brazil
Research Site, Rio de Janeiro, , Brazil
Research Site, Sao Paulo, , Brazil
Research Site, Sao Paulo, , Brazil
Research Site, São José do Rio Preto, , Brazil
Research Site, Calgary, Alberta, Canada
Research Site, Toronto, Ontario, Canada
Research Site, Toronto, Ontario, Canada
Research Site, Montreal, Quebec, Canada
Research Site, Montreal, Quebec, Canada
Research Site, Montreal, Quebec, Canada
Research Site, Montreal, Quebec, Canada
Research Site, Beijing, , China
Research Site, Beijing, , China
Research Site, Changchun, , China
Research Site, Changchun, , China
Research Site, Changsha, , China
Research Site, Changsha, , China
Research Site, Chengdu, , China
Research Site, Chongqing, , China
Research Site, Chongqing, , China
Research Site, Dalian, , China
Research Site, Dalian, , China
Research Site, Guangdong, , China
Research Site, Guangzhou, , China
Research Site, Haikou, , China
Research Site, Harbin, , China
Research Site, Hefei, , China
Research Site, Nanning, , China
Research Site, Shanghai, , China
Research Site, Shenyang, , China
Research Site, Taiyuan, , China
Research Site, Tianjin, , China
Research Site, Wuhan, , China
Research Site, Wuhan, , China
Research Site, Zhanjiang, , China
Research Site, Zhengzhou, , China
Research Site, Zhengzhou, , China
Research Site, Barranquilla, , Colombia
Research Site, Bogota, , Colombia
Research Site, Bogota, , Colombia
Research Site, Bogota, , Colombia
Research Site, Cali, , Colombia
Research Site, Medellin, , Colombia
Research Site, Medellín, , Colombia
Research Site, Monteria, , Colombia
Research Site, Pereira, , Colombia
Research Site, Tallinn, , Estonia
Research Site, Tartu, , Estonia
Research Site, Bonn, , Germany
Research Site, Chemnitz, , Germany
Research Site, Dresden, , Germany
Research Site, Leipzig, , Germany
Research Site, Athens, , Greece
Research Site, Chaidari, , Greece
Research Site, Thessaloniki, , Greece
Research Site, HKG, , Hong Kong
Research Site, Hong Kong, , Hong Kong
Research Site, Budapest, , Hungary
Research Site, Budapest, , Hungary
Research Site, Budapest, , Hungary
Research Site, Debrecen, , Hungary
Research Site, Győr, , Hungary
Research Site, Szolnok, , Hungary
Research Site, Hisar, , India
Research Site, Mumbai, , India
Research Site, Be'er Ya'akov, , Israel
Research Site, Hadera, , Israel
Research Site, Jerusalem, , Israel
Research Site, Nahariya, , Israel
Research Site, Tel Aviv, , Israel
Research Site, Chuo-ku, , Japan
Research Site, Kashiwa-shi, , Japan
Research Site, Koto-ku, , Japan
Research Site, Kurume-shi, , Japan
Research Site, Kyoto-shi, , Japan
Research Site, Matsuyama-shi, , Japan
Research Site, Minato-ku, , Japan
Research Site, Nagoya-shi, , Japan
Research Site, Nakagami-gun, , Japan
Research Site, Niigata-shi, , Japan
Research Site, Osaka-shi, , Japan
Research Site, Osaka, , Japan
Research Site, Sapporo-shi, , Japan
Research Site, Shinjuku-ku, , Japan
Research Site, Sunto-gun, , Japan
Research Site, Toon-Shi, , Japan
Research Site, Tsu-shi, , Japan
Research Site, Yokohama-shi, , Japan
Research Site, Goyang-si, , Korea, Republic of
Research Site, Seoul, , Korea, Republic of
Research Site, Seoul, , Korea, Republic of
Research Site, Seoul, , Korea, Republic of
Research Site, Seoul, , Korea, Republic of
Research Site, Seoul, , Korea, Republic of
Research Site, Seoul, , Korea, Republic of
Research Site, Suwon, , Korea, Republic of
Research Site, Yangsan-si, , Korea, Republic of
Research Site, Kaunas, , Lithuania
Research Site, Vilnius, , Lithuania
Research Site, Vilnius, , Lithuania
Research Site, Aguascalientes, , Mexico
Research Site, Mexico, , Mexico
Research Site, Monterrey, , Mexico
Research Site, Oaxaca, , Mexico
Research Site, Queretaro, , Mexico
Research Site, San Luis Potosi, , Mexico
Research Site, Veracruz, , Mexico
Research Site, Gdansk, , Poland
Research Site, Lublin, , Poland
Research Site, Olsztyn, , Poland
Research Site, Olsztyn, , Poland
Research Site, Łódź, , Poland
Research Site, Anzorey, , Russian Federation
Research Site, Kazan, Tatarstan, , Russian Federation
Research Site, Krasnodar, , Russian Federation
Research Site, Moscow, , Russian Federation
Research Site, Moscow, , Russian Federation
Research Site, Saransk, , Russian Federation
Research Site, Sochi, , Russian Federation
Research Site, St. Petersburg, , Russian Federation
Research Site, Singapore, , Singapore
Research Site, Singapore, , Singapore
Research Site, Singapore, , Singapore
Research Site, Barcelona, , Spain
Research Site, Barcelona, , Spain
Research Site, El Palmar, , Spain
Research Site, Girona, , Spain
Research Site, Jaén, , Spain
Research Site, Madrid, , Spain
Research Site, Mallorca, , Spain
Contact Details
Name: Shannon N. Westin, MD, MPH, FACOG
Affiliation: The University of Texas MD Anderson Cancer Center
Role: PRINCIPAL_INVESTIGATOR
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