Neoplasms

All Conditions

Urinary Tract, Sexual Organs, and Pregnancy Conditions

Carcinoma

Endometrial Neoplasms

Neoplasms, Glandular and Epithelial

Neoplasms by Histologic Type

Uterine Neoplasms

Genital Neoplasms, Female

Urogenital Neoplasms

Uterine Diseases

Genital Diseases, Female

Genital Diseases

Urogenital Diseases

Female Urogenital Diseases

Pregnancy Complications

Female Urogenital Diseases and Pregnancy Complications

Central Nervous System Depressants

All Drugs and Chemicals

Anesthetics

Patient undergoing surgery for strong suspicion of EC

The lavage will be performed in the operating theatre under general anesthesia. The ALPINE technique includes the following steps. A three way catheter (catheter for uterine and tubal lavage) is inserted into the cervical canal and a balloon is inflated to seal the cervical canal. The patient is put into anti-Trendellenburg positioning. Normal saline is slowly flushed into the uterine cavity and proximal tubes. After the lavage is finished, the balloon is deflated and the catheter is removed. A cap is put on the collection syringe and the syringe is sent to the laboratory.

Lavage of the Uterus

Paul Speiser, Prof. Dr. med.

Elisabeth Maritschnegg, MSc.

The current pilot study aims at answering the scientific question, whether exfoliated cells from Endometrium Carcinoma (EC) can be detected in the lavage fluid from the uterine cavity and proximal fallopian tubes with the same sensitivity as in specimen from liquid-based cervical cytology. If this turns out to be the case, earlier detection, particularly of type II EC should be possible.

Endometrial Carcinoma (EC) - carcinoma of the lining of the uterus - is the most common gynecologic malignancy in western civilized countries. Just in the US, approximately 42,160 cases are diagnosed and 7,780 deaths occur annually.

Type I EC is estrogen-dependent and associated with conditions that elevate estrogen levels. The precursor lesion, atypical endometrial hyperplasia, is well described. Type I EC, often of endometroid histology, well differentiated in most cases, is usually diagnosed at an early stage due to irregular bleeding and therefore has a good prognosis.

Type II EC is not estrogen-dependent and of serous or clear cell histology. In contrast to type I cancers, the vast majority, especially of serous cancers, are high grade, affect postmenopausal women, do not cause early symptoms, are diagnosed at an advanced stage, behave more like epithelial ovarian cancer (EOC) and have a very poor prognosis. Precursor lesions in the endometrium are referred to as "serous endometrial intraepithelial carcinoma" (SEIC), lesions quite similar to the precursor lesion of EOC in the fallopian tube, called "serous tubal intraepithelial carcinoma" (STIC).

Unfortunately, most patients with type II epithelial EC, in particular the serous and clear cell carcinomas, experience few or no symptoms until the disease has metastasized. The lack of early symptoms and the absence of a reliable screening test to detect the disease early, result in women being diagnosed after the disease has spread beyond the uterus and therefore has a poor prognosis. For these reasons, there is a clear medical need for earlier diagnosis of type II EC.

Type I and type II uterine tumors also appear to have a different pattern of molecular alterations that underlie pathogenesis and/or progression (1). Alterations in the tumor suppressor gene PTEN, microsatellite instability, and K-ras alterations have been associated with the early development of type I tumors, while these alterations are uncommon in type II cancers. On the other hand, mutations in the TP53 gene appear to be important in the early pathogenesis of uterine serous carcinomas. Moreover, HER2 overexpression/amplification has been associated with type II tumors.

Irregular bleeding as the main symptom of EC is conventionally investigated by "dilation and curettage" and hysteroscopy, a rather invasive procedure requiring general anesthesia and hospital admission. This allows for diagnosis of early stage type I and usually endometroid carcinoma. Bleeding from serous type II EC is examined the same way, but usually, the disease has already progressed into an advanced stage at the time of diagnosis.

The proof of concept that malignant cells from the upper genital tract get transported even into the lower genital tract was recently published by Kinde I. et al. (2). Liquid-based cervical cytology allows not only cytological evaluation but also collection of DNA. A panel of genes that are commonly mutated in endometrial and ovarian cancers was assembled with new whole-exome sequencing data from 22 endometrial cancers and previously published data on other tumor types, including mutations in the TP53 gene. This panel was used to search for mutations in 24 endometrial and 22 ovarian cancers and identified mutations in all 46 samples. Aiming at establishing a possible screening test for EOC and EC, tumor cells were searched for in the DNA obtained through liquid Pap smear. With a sensitive massively parallel sequencing method, it was possible to identify the same mutations in the DNA from liquid Pap smear specimens in 100% of endometrial cancers (24 of 24) and in 41% of ovarian cancers (9 of 22).

A promising approach for the detection of EOC has been established by Paul Speiser and Robert Zeillinger (Molecular Oncology Group, Department of General Gynaecology and Gynaecologic Oncology, Medical University of Vienna, Austria). This approach is called the ALPINE technique (Austrian Lavage Procedure for the Detection of tubal Intraepithelial Neoplasms) (manuscript under preparation). It includes a lavage of the uterine cavity and proximal fallopian tubes and subsequent analysis of this lavage fluid for the presence of pre-malignant and malignant cells.

Uterine lavages were collected before a surgical intervention for suspected ovarian malignancy at the investigators' institution. After malignancy was confirmed, a panel of genetic changes frequently found in endometrial and ovarian cancers (see below) were studied in the lavage samples of 22 ovarian carcinoma patients through deep sequencing by the group of Bert Vogelstein (Johns Hopkins University, Baltimore, USA). The presence of genetic changes, indicative for ovarian cancer, could be confirmed in 16/22 (\~73%) lavage specimen.

The sensitivity in detecting EOC in this pilot study is unprecedented and has sparked further studies, examining the potential of the ALPINE technique in detecting EOC and the precursor lesion of EOC, called STIC. The fact that ovarian cancer cells - collected through the ALPINE technique - were detected with a much higher sensitivity in the lavage, compared to liquid-based cervical cytology, makes the investigators confident that EC detection in lavage specimen should also be possible. If it turns out that already SEICs can be detected in the lavage specimen, this could even result in prevention of type II EC.

The investigators will study about 80 lavage samples and the corresponding EC tissue samples in women who undergo "dilation and curettage" and hysteroscopy for abnormal uterine bleeding and suspected EC. Women who were diagnosed with EC and are scheduled for hysterectomy can also be included in the study. Patients will be recruited into the study until 40 cases of verified ECs and corresponding lavages are collected.

Before "dilation and curettage" and hysteroscopy for abnormal uterine bleeding or before hysterectomy for EC, a lavage of the uterine cavity and proximal fallopian tubes will be obtained. The lavage will be performed in the operating theatre under general anesthesia.

After the lavage is finished, a cap is put on the collection syringe and the syringe is sent to the laboratory. The 10ml uterine aspirate will be centrifuged for 10 minutes at 300 x g. The supernatant and the remaining cell pellet will be frozen at -80°C.

Analysis of the cell pellet will be carried out applying the sensitive massively parallel sequencing method published by Kinde et al. (2). Mutations in the following genes will be analysed: AKT1, APC, BRAF, CTNNB1, EGFR, FBXW7, KRAS, NRAS, PTEN, PIK3CA, PPP2R1A, and TP53.

Considerations on safety and ethical issues:

One concern with the lavage procedure might be that tumor cells from EC might get washed into the peritoneal cavity during the procedure.

During hysteroscopy, the distention media drains through the tubes into the peritoneal cavity in large quantities. A meta-analysis of observational studies reported no significant difference in the frequency of positive peritoneal cytology in women with EC who had or had not undergone diagnostic hysteroscopy (3).

This indicates that transport of EC cells from the uterine cavity into the peritoneal cavity during diagnostic hysteroscopy does not necessarily result in implantation and persistence. In the few studies that have reported long-term follow-up, there was no detriment to survival associated with pre-staging hysterosalpingography (with confirmed intraperitoneal spill) (4) or hysteroscopy (5).

These findings are very reassuring that the lavage of the uterine cavity and proximal tubes by the ALPINE technique is safe.

Conclusion:

If it is possible to detect EC with a very high sensitivity and specifisity by mutation analysis in the lavage of the uterine cavity and fallopian tubes, this result will represent an important finding and might open the opportunity for earlier detection of EC, possibly resulting into a stage shift to earlier stages. That would lead to an improvement of the prognosis, even in type II EC.

Literature:

1. Lax SF Molecular genetic pathways in various types of endometrial carcinoma: from a phenotypical to a molecular-based classification. Virchows Arch. 2004;444(3):213.
2. Kinde I et al. Evaluation of DNA from the Papanicolaou Test to Detect Ovarian and Endometrial Cancers. Sci Transl Med. 2013 Jan 9;5(167):167ra4
3. Yazbeck C, Dhainaut C, Batallan A, et al. \[Diagnostic hysteroscopy and risk of peritoneal dissemination of tumor cells\]. Gynecol Obstet Fertil 2005; 33:247.
4. Devore GR, Schwartz PE, Morris JM. Hysterography: a 5-year follow-up in patients with endometrial carcinoma. Obstet Gynecol 1982; 60:369.
5. Ben-Arie A, Tamir S, Dubnik S, et al. Does hysteroscopy affect prognosis in apparent early-stage endometrial cancer? Int J Gynecol Cancer 2008; 18:813.

LUDEC Study - Pilot Study of the Lavage of the Uterine Cavity for the Diagnosis of Endometrial Carcinoma

Medical University of Vienna

Professor Dr. (M.D.)

Antineoplastic Agents

Lenvatinib

Pembrolizumab

Vaccines

Immunomodulating Agents

Antineoplastic Agents, Immunological

Immune Checkpoint Inhibitors

Protein Kinase Inhibitors

Enzyme Inhibitors

AdHER2DC vaccine + pembrolizumab + de-escalating doses of lenvatinib

AdHER2DC vaccine + N-803 + pembrolizumab + RP2D of lenvatinib

AdHER2DC vaccine is given by intradermal injections on Day 1 of cycles 1-3 (priming) followed by optional boost doses (up to 3), on Day 1 of cycles 6, 9, 12

AdHER2DC vaccine

Pembrolizumab is given by IV infusion on Day 8 of cycle 1 and Day 1 of cycles 2-16

N-803 is given by subcutaneous injections on Day 1 of cycles 1-16

N-803

Lenvatinib is taken orally on Days 8-28 on cycle 1 and every day of cycles 2-16

Used during screening to estimate eligibility

PATHWAY HER2 (4B5) assay

Hoyoung M Maeng, M.D.

Background:

Endometrial cancer (EC) of the uterus is becoming more common in the US. Sometimes EC often has increased levels of a protein called HER2. Cancers with HER2 tend to be more aggressive and have poorer outcomes.

Objective:

To test 2 study drugs-a vaccine that targets HER2 (AdHER2DC) plus a drug that supercharges immune cells that kill tumor cells (N-803)-combined with 2 FDA-approved cancer treatment drugs in people with EC.

Eligibility:

Adults aged 18 and older with HER2-positive EC that returned or got worse after treatment.

Design:

AdHER2DC vaccine is made from each participant s own blood. Participants will undergo apheresis: Blood is removed from the body through a tube attached to a needle. The blood passes through a machine that separates out the target cells. The remaining blood is returned to the body through a second needle. A special catheter may be needed.

The first treatment cycle is 28 days; each cycle after that will be 21 days.

All participants will get the 2 approved drugs and the vaccine. One drug is a tablet taken by mouth once a day, every day. The other drug is given through a tube attached to a needle inserted into a vein.

The vaccine is injected under the skin. Participants will receive the vaccine on day 1 of cycles 1, 2, and 3. Additional doses up to 3 doses will be give if possible.

Some participants will receive N-803. This drug is injected under the skin of the abdomen on day 1 of each cycle.

Treatment may last up to 1 year. Follow-up visits will continue up to 2 more years.

BACKGROUND:

* Endometrial cancer (EC) is the most common gynecologic cancer in the US and the incidence peaks around 50-60 years of age. 5-year overall survival in patients with metastasis is around 20 percent and treatment after the second-line treatment has not been effective for long-term control.
* Pembrolizumab is approved for microsatellite instability (MSI)-high endometrial cancer which is rare.
* Pembrolizumab and lenvatinib combination therapy as second-line therapy in patients with advanced or metastatic EC showed promising antitumor activity. Recently, the Food and Drug Administration (FDA) approved pembrolizumab and lenvatinib in patients with advanced endometrial cancer who received prior chemotherapy after decades of lapse in adding new treatment options with an improved progression free survival (PFS) 6.6 months (vs 3.8 months in standard care chemotherapy), overall response rate 30 percent and median duration of response of 9.2 months.
* HER2 is positive in 30 percent of endometrial cancer and anti-HER2 therapy has shown clinical benefit in metastatic EC. Trastuzumab is used off-label with chemotherapy and as maintenance.
* An autologous dendritic cell vaccine that is transduced with an adenoviral vector expressing extracellular domain and transmembrane domain of HER2 (AdHER2DC vaccine) was well tolerated and showed a preliminary clinical benefit of 33.3 percent among 21 evaluable patients (NCT01730118, total enrolled n=33). No cardiotoxicity was noted. Immunogenicity analysis in a limited number of patients suggested induction of both humoral and cellular immune responses.
* The combination of pembrolizumab and lenvatinib in EC showed antitumor activity with manageable toxicity but still showed the responses in a limited group of patients. To overcome the resistance to immune checkpoint inhibitors, the combination regimen to induce the antitumor immune response by the AdHER2 vaccine, control the negative immune regulators and hostile tumor microenvironment by vascular endothelial growth factor (VEGF) inhibitor lenvatinib, and an immune stimulatory cytokine IL-15 superagonist N-803 has the potential to make the tumor more responsive to the immunotherapy creating mutual synergy.

OBJECTIVES:

* Phase I: To estimate recommended Phase II dose (RP2D) of pembrolizumab, lenvatinib, N-803, and AdHER2DC vaccine in participants with HER2 positive endometrial cancer.
* Phase II: To preliminarily assess the efficacy of a combination of pembrolizumab, lenvatinib, N-803, and AdHER2DC vaccine in participants with HER2 positive endometrial cancer as determined by the proportion of participants without progression at 6 months.

ELIGIBILITY CRITERIA:

* Age \>=18 years.
* Metastatic or locally advanced endometrial cancer with HER2 immunohistochemistry (IHC) 1+, 2+ or 3+
* Progressed after at least 1 line of standard of care (SOC) systemic therapy Participants may have received any number of prior cytotoxic agents and no prior checkpoint inhibitors.
* ECOG performance status \<=2 and adequate organ function.

DESIGN:

* An open-label, two-arm, phase I/II study of pembrolizumab, lenvatinib, N-803, and AdHER2.
* During Phase I, we will estimate recommended Phase II dose (RP2D) of the lenvatinib in combination with AdHER2DC vaccine, pembrolizumab, and N-803.
* During Phase II we will continue to evaluate the safety and examine the efficacy of the study regimen at the RP2D of the lenvatinib in combination with AdHER2 DC vaccine, pembrolizumab, and N-803.
* Participants will undergo apheresis, and AdHER2DC vaccine will be generated by transducing the participants monocyte-derived dendritic cells with AdHER2 vector.
* Treatment will be delivered for up to 1 year or until progression or unacceptable toxicity.
* Up to 60 participants will be treated.

Pembrolizumab, Lenvatinib and IL-15 Superagonist N-803 in Combination With HER2 Targeting Autologous Dendritic Cell (AdHER2DC) Vaccine in Participants With Advanced or Metastatic Endometrial Cancer

Phase I/II Trial of Pembrolizumab, Lenvatinib and IL-15 Superagonist N-803 in Combination With HER2 Targeting Autologous Dendritic Cell (AdHER2DC) Vaccine in Participants With Advanced or Metastatic Endometrial Cancer (EC)

.All IPD recorded in the medical record will be shared with intramural investigators upon request. In addition, all large scale genomic sequencing data will be shared with subscribers to dbGap.

Number of Dose Limiting Toxicities (DLT).

Defined as the time from the start of treatment to time of progression, death, or 6 months. The fraction who can be alive without progression at 6 months will be reported along with an 80% two-sided confidence interval (the lower bound is the one-sided 90% bound, which will be used to compare to an estimated 54-55% from the Makker 2022 result) and a 95% two-sided confidence interval.

For participants receiving 4 agents, their safety will be evaluated with respect to the grades and types of toxicities obtained. The results will be presented descriptively and tabled if appropriate.

National Cancer Institute (NCI)

Skin and Connective Tissue Diseases

Gland and Hormone Related Diseases

Rare Diseases

Breast Neoplasms

Ovarian Neoplasms

Carcinoma, Ovarian Epithelial

Breast Diseases

Skin Diseases

Endocrine Gland Neoplasms

Ovarian Diseases

Adnexal Diseases

Endocrine System Diseases

Gonadal Disorders

Ovarian Cancer

Ovarian Epithelial Cancer

PF-07260437

B7-H4 IHC

Pfizer CT.gov Call Center

A study to evaluate the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD), and antitumor activity of PF-07260437, a B7-H4 x CD3 bispecific mAb, in participants aged ≥18 years of age with advanced or metastatic breast cancer, ovarian cancer or endometrial cancer. Adult participants with other advanced or metastatic high B7-H4 expressing tumors may be considered after discussion with and approval from sponsor.

A Study of PF-07260437 in Advanced or Metastatic Solid Tumors

A PHASE 1 DOSE ESCALATION AND EXPANSION STUDY TO EVALUATE THE SAFETY, TOLERABILITY, PHARMACOKINETIC, PHARMACODYNAMIC, AND ANTITUMOR ACTIVITY OF PF-07260437 IN ADVANCED OR METASTATIC SOLID TUMORS

Pfizer will provide access to individual de-identified participant data and related study documents (e.g. protocol, Statistical Analysis Plan (SAP), Clinical Study Report (CSR)) upon request from qualified researchers, and subject to certain criteria, conditions, and exceptions. Further details on Pfizer's data sharing criteria and process for requesting access can be found at: https://www.pfizer.com/science/clinical_trials/trial_data_and_results/data_requests.

DLTs will be evaluated in Part 1. The number of DLTs will be used to determine the dose escalation decision and recommended dose of PF-07260437

DOR as assessed using RECIST 1.1 and irRECIST

TTP as assessed using RECIST 1.1 and irRECIST

ORR as assessed using RECIST 1.1 and irRECIST

PFS as assessed using RECIST 1.1 and irRECIST

Immune Cells assessments from paired biopsies

Pfizer

Fluorescence-guided sentinel lymph node detection

During standard endometrial cancer surgery, ICG dye will be injected into the cervix to identify sentinel lymph nodes in the pelvis.

Pamela Paley, MD

The main purpose of the study is to evaluate the detection rate and accuracy of fluorescence imaging in endometrial cancer staging by sentinel node assessment.

In many cancer types, such as breast cancer and melanoma, sentinel node assessment has become the standard of care surgical treatment. Sentinel nodes are the first lymph nodes to which cancer cells are likely to spread from a primary tumor. Removal of a sentinel node for examination accurately predicts whether the cancer has spread to other nodes further along in the nodal chain. Fluorescence imaging with ICG dye (Indocyanine Green) has been used to detect lymph nodes in patients with gastric, colorectal and breast cancer. To date, the use of this technique in endometrial cancer has not been reported.

Investigating the Use of Fluorescence Imaging in Endometrial Cancer Surgery

A Prospective Investigation of the Use of Fluorescence Imaging on the da Vinci Surgical System for Ultrastaging of Endometrial Cancer by Sentinel Node Assessment

In cancer, "upstaging" is changing the stage used to describe a patient's cancer from a lower stage (less extensive) to a higher stage (more extensive). The sentinel lymph nodes removed during the flourescence guided surgery will be examined microscopically to determine how often upstaging occurred.

Swedish Medical Center

Symptoms and General Pathology

Recurrence

Paclitaxel

Albumin-Bound Paclitaxel

Carboplatin

Durvalumab

Olaparib

Antibodies

Antibodies, Monoclonal

Immunoglobulins

Tubulin Modulators

Antimitotic Agents

Immunologic Factors

Poly(ADP-ribose) Polymerase Inhibitors

Platinum-based chemotherapy and durvalumab placebo followed by maintenance durvalumab placebo and olaparib placebo (tablets).

Platinum-based chemotherapy and durvalumab followed by maintenance durvalumab and olaparib placebo

Platinum-based chemotherapy and durvalumab followed by maintenance durvalumab and olaparib.

olaparib

durvalumab

Matching placebo for intravenous infusion

durvalumab placebo

olaparib placebo

Shannon N. Westin, MD, MPH, FACOG

A study to assess the efficacy and safety of durvalumab in combination with platinum-based chemotherapy (paclitaxel + carboplatin) followed by maintenance durvalumab with or without olaparib for patients with newly diagnosed advanced or recurrent endometrial cancer.

This Phase III study will assess the efficacy and safety of durvalumab in combination with platinum-based chemotherapy (paclitaxel + carboplatin) followed by maintenance durvalumab with or without olaparib for patients with newly diagnosed advanced or recurrent endometrial cancer.

Target patient population: Adult female patients with histologically confirmed diagnosis of epithelial endometrial carcinoma (excluding sarcomas): newly diagnosed Stage III, newly diagnosed Stage IV, or recurrent endometrial cancer

Durvalumab With or Without Olaparib as Maintenance Therapy After First-Line Treatment of Advanced and Recurrent Endometrial Cancer

A Randomised, Multicentre, Double-blind, Placebo-controlled, Phase III Study of First-line Carboplatin and Paclitaxel in Combination With Durvalumab, Followed by Maintenance Durvalumab With or Without Olaparib in Patients With Newly Diagnosed Advanced or Recurrent Endometrial Cancer (DUO-E)

Qualified researchers can request access to anonymized individual patient-level data from AstraZeneca group of companies sponsored clinical trials via the request portal.

All request will be evaluated as per the AZ disclosure commitment:

https://astrazenecagrouptrials.pharmacm.com/ST/Submission/Disclosure

Defined as the time from randomisation until the date of objective disease progression (per RECIST 1.1 as assessed by investigator) or death (by any cause in the absence of progression)

Defined as the time from randomisation to the earliest of progression event subsequent to first subsequent therapy (assessed by the investigator per local standard clinical practice and may involve any of the following: objective radiological imaging, symptomatic progression), or death due to any cause

Defined as the time from randomisation to death due to any cause

Defined as the proportion of patients with measurable disease at baseline who have confirmed complete response (CR) or partial response (PR) as determined by the Investigator at local site.

Defined as time from the date of first documented response until date of documented progression or death in the absence of disease progression

Defined as the time from randomisation to the earlier of start date of the first subsequent anti-cancer therapy after discontinuation of randomised treatment or death due to any cause

Defined as the time from randomisation to the earlier of start date of the second subsequent anti-cancer therapy after discontinuation of first subsequent treatment or death due to any cause.

Defined as the time from randomisation to the earlier of the date of study treatment discontinuation or death.

Determination of durvalumab concentration in serum

Graded according to the National Cancer Institute (NCI CTCAE)

Determination concentration of Anti-drug antibodies (ADA) to durvalumab in serum

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
LUDEC Study - Pilot Study of the Lavage of the Uterine Cavity for the Diagnosis of Endometrial Carcinoma	NCT02387645	Cancer of Endom... Carcinoma of En... Endometrial Neo...	Lavage of the U...	18 Years - 80 Years	Medical University of Vienna
Pembrolizumab, Lenvatinib and IL-15 Superagonist N-803 in Combination With HER2 Targeting Autologous Dendritic Cell (AdHER2DC) Vaccine in Participants With Advanced or Metastatic Endometrial Cancer	NCT06253494	Endometrial Can... Cancer of Endom... Carcinoma of En... Endometrial Car...	AdHER2DC vaccin... Pembrolizumab N-803 Lenvatinib PATHWAY HER2 (4...	18 Years - 120 Years	National Institutes of Health Clinical Center (CC)
A Study of PF-07260437 in Advanced or Metastatic Solid Tumors	NCT05067972	Ovarian Neoplas... Endometrial Neo... Breast Neoplasm...	PF-07260437 B7-H4 IHC	18 Years -	Pfizer
Investigating the Use of Fluorescence Imaging in Endometrial Cancer Surgery	NCT01562106	Endometrial Can...	Fluorescence-gu...	18 Years -	Swedish Medical Center
Investigating the Use of Fluorescence Imaging in Endometrial Cancer Surgery	NCT01562106	Endometrial Can...	Fluorescence-gu...	18 Years -	Swedish Medical Center
A Study of PF-07260437 in Advanced or Metastatic Solid Tumors	NCT05067972	Ovarian Neoplas... Endometrial Neo... Breast Neoplasm...	PF-07260437 B7-H4 IHC	18 Years -	Pfizer
Durvalumab With or Without Olaparib as Maintenance Therapy After First-Line Treatment of Advanced and Recurrent Endometrial Cancer	NCT04269200	Endometrial Neo...	olaparib durvalumab durvalumab plac... olaparib placeb... Carboplatin Paclitaxel	18 Years - 150 Years	AstraZeneca

Spots Global Cancer Trial Database for carcinoma of endometrium