Spots Global Cancer Trial Database for Circumferential Section Pane Less Than 1 mm in Esophagectomy for Esophageal Cancer.

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Trial Identification

Brief Title: Circumferential Section Pane Less Than 1 mm in Esophagectomy for Esophageal Cancer.

Official Title: Prognostic Value of a Circumferential Section Pane Less Than 1 mm in Esophagectomy for Esophageal Cancer.

Study ID: NCT01959906

Conditions

Esophageal Cancer

Interventions

Study Description

Brief Summary: A suspicious circumferential resection margin (CRM), defined as tumor cells within 1 mm of the CRM, is still controversial. The aim of this study was to compare the clinical significance of a suspicious CRM to histologically positive (R1) and negative margin (R0) resections in patients with pT3 esophageal and GE-Junction tumors.

Detailed Description: From our prospectively build database 923 consecutive pT3 patients operated between january 1990 and june 2013 were selected. CRM status in patients treated by surgery only (n = 747) or after neoadjuvant therapy (n = 176) was recorded prospectively after surgery. Kaplan-Meier survival curves were generated, and factors affecting survival were assessed by Cox regression multivariate analysis.