Spots Global Cancer Trial Database for BMS-247550 in Treating Patients With Metastatic Stomach Cancer Previously Treated With Chemotherapy

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Trial Identification

Brief Title: BMS-247550 in Treating Patients With Metastatic Stomach Cancer Previously Treated With Chemotherapy

Official Title: A Phase II Study of Epothilone Analog BMS-247550 in Patients With Metastatic Gastric Adenocarcinoma Previously Treated With a Taxane

Study ID: NCT00017043

Conditions

Esophageal Cancer

Gastric Cancer

Interventions

ixabepilone

Study Description

Brief Summary: RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. PURPOSE: Phase II trial to study the effectiveness of BMS-247550 in treating patients who have metastatic stomach cancer previously treated with chemotherapy.

Detailed Description: OBJECTIVES: * Determine the clinical activity of BMS-247550, in terms of response rate, in patients with previously treated metastatic gastric adenocarcinoma. * Determine the safety of this drug in these patients. * Assess the response duration, time to progression, and survival of patients treated with this drug. OUTLINE: This is a multicenter study. Patients receive BMS-247550 IV over 1 hour on day 1. Treatment repeats every 21 days for 2-18 courses in the absence of disease progression or unacceptable toxicity. Patients with a complete response (CR) receive 4 additional courses after confirmation of CR. Patients are followed every 3 months. PROJECTED ACCRUAL: A total of 21-58 patients will be accrued for this study within 1 year.