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Spots Global Cancer Trial Database for CHFR Methylation Status Esophageal Cancer Study

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We do not endorse or review these studies in any way.

Trial Identification

Brief Title: CHFR Methylation Status Esophageal Cancer Study

Official Title: A Phase 2 Study of Paclitaxel With Cisplatin Versus Fluoropyrimidine With a Platinum Agent for Neoadjuvant Therapy in Operable Esophageal Cancer Based on CHFR Methylation Status in Diagnostic Biopsies

Study ID: NCT01372202

Study Description

Brief Summary: This is a Phase 2 Study of Paclitaxel with Cisplatin versus Fluoropyrimidine with a Platinum Agent for Neoadjuvant Therapy in Operable Esophageal Cancer Based on CHFR Methylation Status in Diagnostic Biopsies.

Detailed Description: Primary Objectives • To determine the rate of pathological complete response when the inclusion of paclitaxel in neoadjuvant therapy is based on the presence or absence of CHFR methylation in diagnostic biopsy specimens. Secondary Objectives * To determine the survival outcome with this treatment strategy. * To determine time to disease progression with this treatment strategy. * To determine the agreement between tumor CHFR methylation and detection in plasma.

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: No

Locations

Ronan Kelly, M.D., Baltimore, Maryland, United States

Contact Details

Name: Ronan Kelly, M.D.

Affiliation: Johns Hopkins University

Role: PRINCIPAL_INVESTIGATOR

Useful links and downloads for this trial

Clinicaltrials.gov

Google Search Results

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