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Brief Title: CHFR Methylation Status Esophageal Cancer Study
Official Title: A Phase 2 Study of Paclitaxel With Cisplatin Versus Fluoropyrimidine With a Platinum Agent for Neoadjuvant Therapy in Operable Esophageal Cancer Based on CHFR Methylation Status in Diagnostic Biopsies
Study ID: NCT01372202
Brief Summary: This is a Phase 2 Study of Paclitaxel with Cisplatin versus Fluoropyrimidine with a Platinum Agent for Neoadjuvant Therapy in Operable Esophageal Cancer Based on CHFR Methylation Status in Diagnostic Biopsies.
Detailed Description: Primary Objectives • To determine the rate of pathological complete response when the inclusion of paclitaxel in neoadjuvant therapy is based on the presence or absence of CHFR methylation in diagnostic biopsy specimens. Secondary Objectives * To determine the survival outcome with this treatment strategy. * To determine time to disease progression with this treatment strategy. * To determine the agreement between tumor CHFR methylation and detection in plasma.
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Ronan Kelly, M.D., Baltimore, Maryland, United States
Name: Ronan Kelly, M.D.
Affiliation: Johns Hopkins University
Role: PRINCIPAL_INVESTIGATOR