Spots Global Cancer Trial Database for Chemotherapy and Radiation Therapy After Surgery in Treating Patients With Stomach or Esophageal Cancer
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Trial Identification
Brief Title: Chemotherapy and Radiation Therapy After Surgery in Treating Patients With Stomach or Esophageal Cancer
Official Title: Phase III Intergroup Trial of Adjuvant Chemoradiation After Resection of Gastric or Gastroesophageal Adenocarcinoma
Study ID: NCT00052910
Study Description
Brief Summary: RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells. Combining chemotherapy with radiation therapy after surgery may kill any remaining tumor cells following surgery. It is not yet known which chemotherapy and radiation therapy regimen is more effective in treating stomach or esophageal cancer. PURPOSE: Randomized phase III trial to compare two different chemotherapy and radiation therapy regimens in treating patients who have undergone surgery for stomach or esophageal cancer.
Detailed Description: OBJECTIVES: * Compare overall survival in patients with resected gastric adenocarcinoma treated with epirubicin, cisplatin, and infusional fluorouracil (5-FU) vs 5-FU bolus and leucovorin calcium before and after 5-FU plus radiotherapy. * Compare disease-free survival and local and distant recurrence rates in these patients treated with these regimens. * Correlate the expression of putative prognostic markers (including TS, ERCC-1, MSI, E-cadherin, EGFR, p27, COX-2, and c-erbB-2) with overall survival of patients treated with these regimens. * Correlate specific germline polymorphisms related to chemotherapy metabolism and resistance (including UGT2B7 \[epirubicin\], GST \[cisplatin\], ERCCI \[cisplatin\], XRCC1 \[cisplatin\], TS \[5-FU\], DPD \[5-FU\], and EGFR polymorphisms) with treatment-related toxicity and overall survival of these patients. * Correlate serum levels of insulin-like growth factor-1 (IGF-1), IGF-2, and IGF-binding protein 3 with overall survival of patients treated with these regimens. OUTLINE: This is a randomized, multicenter study. Patients are stratified according to depth of tumor penetration (T1 or T2 vs T3 vs T4), lymph node involvement (0 vs 1-3), and extent of lymphadenectomy (D1 or D2 vs D0 or unknown). Patients are randomized to 1 of 2 treatment arms. * Arm I: Patients receive leucovorin calcium IV and fluorouracil (5-FU) IV on days 1-5 of courses 1, 3, and 4. Courses repeat every 28 days. During course 2, patients undergo radiotherapy 5 days a week and receive 5-FU IV continuously for 5 weeks. Patients rest for 28-35 days between course 2 and 3. * Arm II: Patients receive epirubicin IV over 3-15 minutes and cisplatin IV over 1 hour on day 1 and 5-FU IV continuously on days 1-21 during course 1. Beginning 1 week later, patients undergo radiotherapy 5 days a week and receive 5-FU IV continuously for 5 weeks. Patients rest for 28-35 days before beginning course 2 of chemotherapy. Patients then receive epirubicin, cisplatin, and 5-FU as in course 1. Treatment repeats every 21 days for 2 courses. Patients are followed every 3 months for 2 years, every 4 months for 2 years, and then annually for 3 years. PROJECTED ACCRUAL: A total of 824 patients will be accrued for this study.
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
Regional Medical Center, Anniston, Alabama, United States
Providence Cancer Center at Providence Hospital, Mobile, Alabama, United States
Mayo Clinic Scottsdale, Scottsdale, Arizona, United States
Arizona Cancer Center at University of Arizona Health Sciences Center, Tucson, Arizona, United States
Hembree Mercy Cancer Center at St. Edward Mercy Medical Center, Fort Smith, Arkansas, United States
Ben E. Owens Cancer Treatment Center at St. Bernard's Medical Center, Jonesboro, Arkansas, United States
Arkansas Cancer Research Center at University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States
Kaiser Permanente - Deer Valley, Antioch, California, United States
Providence Saint Joseph Medical Center - Burbank, Burbank, California, United States
East Bay Radiation Oncology Center, Castro Valley, California, United States
Eden Medical Center, Castro Valley, California, United States
Valley Medical Oncology Consultants - Castro Valley, Castro Valley, California, United States
City of Hope Comprehensive Cancer Center, Duarte, California, United States
Kaiser Permanente - Fremont, Fremont, California, United States
Valley Medical Oncology, Fremont, California, United States
Glendale Memorial Hospital Comprehensive Cancer Center, Glendale, California, United States
Kaiser Permanente Medical Center - Hayward, Hayward, California, United States
Rebecca and John Moores UCSD Cancer Center, La Jolla, California, United States
Contra Costa Regional Medical Center, Martinez, California, United States
Memorial Medical Center, Modesto, California, United States
Community Hospital of the Monterey Peninsula Comprehensive Cancer Center, Monterey, California, United States
Camino Medical Group - Treatment Center, Mountain View, California, United States
El Camino Hospital Cancer Center, Mountain View, California, United States
Highland General Hospital, Oakland, California, United States
Alta Bates Summit Medical Center - Summit Campus, Oakland, California, United States
Bay Area Breast Surgeons, Incorporated, Oakland, California, United States
CCOP - Bay Area Tumor Institute, Oakland, California, United States
Larry G Strieff MD Medical Corporation, Oakland, California, United States
Tom K Lee, Incorporated, Oakland, California, United States
Kaiser Permanente Medical Center - Oakland, Oakland, California, United States
Valley Care Medical Center, Pleasanton, California, United States
Valley Medical Oncology Consultants - Pleasanton, Pleasanton, California, United States
Kaiser Permanente Medical Center - Redwood City, Redwood City, California, United States
Kaiser Permanente Medical Center - Richmond, Richmond, California, United States
Kaiser Permanente Medical Center - Roseville, Roseville, California, United States
South Sacramento Kaiser-Permanente Medical Center, Sacramento, California, United States
Kaiser Permanente Medical Center - Sacramento, Sacramento, California, United States
San Francisco General Hospital Medical Center, San Francisco, California, United States
Kaiser Permanente Medical Center - San Francisco Geary Campus, San Francisco, California, United States
Kaiser Permanente Medical Center - Santa Teresa, San Jose, California, United States
Doctors Medical Center - San Pablo Campus, San Pablo, California, United States
Kaiser Foundation Hospital - San Rafael, San Rafael, California, United States
Kaiser Permanente Medical Center - Santa Clara Kiely Campus, Santa Clara, California, United States
Kaiser Permanente Medical Center - Santa Rosa, Santa Rosa, California, United States
Kaiser Permanente Medical Center - South San Francisco, South San Francisco, California, United States
Kaiser Permanente Medical Facility - Stockton, Stockton, California, United States
Kaiser Permanente Medical Center - Vallejo, Vallejo, California, United States
Kaiser Permanente Medical Center - Walnut Creek, Walnut Creek, California, United States
Aurora Presbyterian Hospital, Aurora, Colorado, United States
Boulder Community Hospital, Boulder, Colorado, United States
Memorial Hospital Cancer Center - Colorado Springs, Colorado Springs, Colorado, United States
Penrose Cancer Center at Penrose Hospital, Colorado Springs, Colorado, United States
St. Anthony Central Hospital, Denver, Colorado, United States
Porter Adventist Hospital, Denver, Colorado, United States
Presbyterian - St. Luke's Medical Center, Denver, Colorado, United States
St. Joseph Hospital, Denver, Colorado, United States
Rose Medical Center, Denver, Colorado, United States
CCOP - Colorado Cancer Research Program, Denver, Colorado, United States
Swedish Medical Center, Englewood, Colorado, United States
St. Mary's Regional Cancer Center at St. Mary's Hospital and Medical Center, Grand Junction, Colorado, United States
North Colorado Medical Center, Greeley, Colorado, United States
Sky Ridge Medical Center, Lone Tree, Colorado, United States
Hope Cancer Care Center at Longmont United Hospital, Longmont, Colorado, United States
McKee Medical Center, Loveland, Colorado, United States
St. Mary - Corwin Regional Medical Center, Pueblo, Colorado, United States
North Suburban Medical Center, Thornton, Colorado, United States
Exempla Lutheran Medical Center, Wheat Ridge, Colorado, United States
Praxair Cancer Center at Danbury Hospital, Danbury, Connecticut, United States
Helen and Harry Gray Cancer Center at Hartford Hospital, Hartford, Connecticut, United States
Tunnell Cancer Center at Beebe Medical Center, Lewes, Delaware, United States
CCOP - Christiana Care Health Services, Newark, Delaware, United States
Lombardi Comprehensive Cancer Center at Georgetown University Medical Center, Washington, District of Columbia, United States
Walter Reed Army Medical Center, Washington, District of Columbia, United States
Eugene M. and Christine E. Lynn Cancer Institute at Boca Raton Community Hospital - Main Campus, Boca Raton, Florida, United States
Michael and Dianne Bienes Comprehensive Cancer Center at Holy Cross Hospital, Fort Lauderdale, Florida, United States
Broward General Medical Center Cancer Center, Fort Lauderdale, Florida, United States
Memorial Cancer Institute at Memorial Regional Hospital, Hollywood, Florida, United States
Baptist Cancer Institute - Jacksonville, Jacksonville, Florida, United States
Ella Milbank Foshay Cancer Center at Jupiter Medical Center, Jupiter, Florida, United States
Center for Cancer Care and Research at Watson Clinic, LLP, Lakeland, Florida, United States
CCOP - Mount Sinai Medical Center, Miami Beach, Florida, United States
Sacred Heart Cancer Center at Sacred Heart Hospital, Pensacola, Florida, United States
West Florida Cancer Institute at West Florida Hospital - Pensacola, Pensacola, Florida, United States
Cleveland Clinic Florida - Weston, Weston, Florida, United States
Phoebe Cancer Center at Phoebe Putney Memorial Hospital, Albany, Georgia, United States
Winship Cancer Institute of Emory University, Atlanta, Georgia, United States
Veterans Affairs Medical Center - Atlanta (Decatur), Decatur, Georgia, United States
Medical Center of Central Georgia, Macon, Georgia, United States
Curtis and Elizabeth Anderson Cancer Institute at Memorial Health University Medical Center, Savannah, Georgia, United States
Nancy N. and J. C. Lewis Cancer and Research Pavilion at St. Joseph's/Candler, Savannah, Georgia, United States
Mountain States Tumor Institute at St. Luke's Regional Medical Center, Boise, Idaho, United States
Rush-Copley Cancer Care Center, Aurora, Illinois, United States
Hematology Oncology Associates of Illinois - Berwyn, Berwyn, Illinois, United States
Robert H. Lurie Comprehensive Cancer Center at Northwestern University, Chicago, Illinois, United States
Hematology and Oncology Associates, Chicago, Illinois, United States
University of Illinois Cancer Center, Chicago, Illinois, United States
Veterans Affairs Medical Center - Chicago Westside Hospital, Chicago, Illinois, United States
Resurrection Medical Center, Chicago, Illinois, United States
University of Chicago Cancer Research Center, Chicago, Illinois, United States
Creticos Cancer Center at Advocate Illinois Masonic Medical Center, Chicago, Illinois, United States
Decatur Memorial Hospital Cancer Care Institute, Decatur, Illinois, United States
St. Anthony's Memorial Hospital, Effingham, Illinois, United States
Elmhurst Memorial Hospital, Elmhurst, Illinois, United States
Ingalls Cancer Care Center at Ingalls Memorial Hospital, Harvey, Illinois, United States
Veterans Affairs Medical Center - Hines, Hines, Illinois, United States
Midwest Center for Hematology/Oncology, Joliet, Illinois, United States
Joliet Oncology-Hematology Associates, Limited - West, Joliet, Illinois, United States
La Grange Memorial Hospital, La Grange, Illinois, United States
North Shore Oncology and Hematology Associates, Limited - Libertyville, Libertyville, Illinois, United States
Cardinal Bernardin Cancer Center at Loyola University Medical Center, Maywood, Illinois, United States
Edward Hospital Cancer Center, Naperville, Illinois, United States
Hematology Oncology Consultants - Naperville, Naperville, Illinois, United States
La Grange Oncology Associates - Geneva, Naperville, Illinois, United States
Cancer Care and Hematology Specialists of Chicagoland - Niles, Niles, Illinois, United States
Advocate Christ Medical Center, Oak Lawn, Illinois, United States
Saint James Hospital and Health Centers Comprehensive Cancer Institute - Olympia Fields, Olympia Fields, Illinois, United States
West Suburban Center for Cancer Care, River Forest, Illinois, United States
Swedish-American Regional Cancer Center, Rockford, Illinois, United States
Hematology Oncology Associates - Skokie, Skokie, Illinois, United States
Regional Cancer Center at Memorial Medical Center, Springfield, Illinois, United States
Carle Cancer Center at Carle Foundation Hospital, Urbana, Illinois, United States
CCOP - Carle Cancer Center, Urbana, Illinois, United States
St. Francis Hospital and Health Centers - Beech Grove Campus, Beech Grove, Indiana, United States
Elkhart General Hospital, Elkhart, Indiana, United States
Fort Wayne Medical Oncology and Hematology, Fort Wayne, Indiana, United States
Indiana University Melvin and Bren Simon Cancer Center, Indianapolis, Indiana, United States
William N. Wishard Memorial Hospital, Indianapolis, Indiana, United States
Howard Community Hospital, Kokomo, Indiana, United States
Center for Cancer Therapy at LaPorte Hospital and Health Services, La Porte, Indiana, United States
Saint Anthony Memorial Health Centers, Michigan City, Indiana, United States
Cancer Center at Ball Memorial Hospital, Muncie, Indiana, United States
Medical Consultants, PC at Ball Memorial Cancer Center, Muncie, Indiana, United States
Community Hospital, Munster, Indiana, United States
Reid Hospital & Health Care Services, Richmond, Indiana, United States
CCOP - Northern Indiana CR Consortium, South Bend, Indiana, United States
Memorial Hospital of South Bend, South Bend, Indiana, United States
Saint Joseph Regional Medical Center, South Bend, Indiana, United States
South Bend Clinic, South Bend, Indiana, United States
McFarland Clinic, PC, Ames, Iowa, United States
Hematology Oncology Associates of the Quad Cities, Bettendorf, Iowa, United States
Iowa Blood and Cancer Care, Cedar Rapids, Iowa, United States
St. Luke's Hospital, Cedar Rapids, Iowa, United States
Mercy Regional Cancer Center at Mercy Medical Center, Cedar Rapids, Iowa, United States
Mercy Capitol Hospital, Des Moines, Iowa, United States
CCOP - Iowa Oncology Research Association, Des Moines, Iowa, United States
John Stoddard Cancer Center at Iowa Methodist Medical Center, Des Moines, Iowa, United States
Medical Oncology and Hematology Associates at John Stoddard Cancer Center, Des Moines, Iowa, United States
Medical Oncology and Hematology Associates at Mercy Cancer Center, Des Moines, Iowa, United States
Mercy Cancer Center at Mercy Medical Center - Des Moines, Des Moines, Iowa, United States
John Stoddard Cancer Center at Iowa Lutheran Hospital, Des Moines, Iowa, United States
Holden Comprehensive Cancer Center at University of Iowa, Iowa City, Iowa, United States
McCreery Cancer Center at Ottumwa Regional, Ottumwa, Iowa, United States
Siouxland Hematology-Oncology Associates, LLP, Sioux City, Iowa, United States
Mercy Medical Center - Sioux City, Sioux City, Iowa, United States
St. Luke's Regional Medical Center, Sioux City, Iowa, United States
Cedar Valley Medical Specialists, PC - West Ridgeway Avenue, Waterloo, Iowa, United States
Covenant Cancer Treatment Center, Waterloo, Iowa, United States
Medical Oncology and Hematology Associates - West Des Moines, West Des Moines, Iowa, United States
Cancer Center of Kansas, PA - Chanute, Chanute, Kansas, United States
Cancer Center of Kansas, PA - Dodge City, Dodge City, Kansas, United States
Cancer Center of Kansas, PA - El Dorado, El Dorado, Kansas, United States
Cancer Center of Kansas - Fort Scott, Fort Scott, Kansas, United States
Cancer Center of Kansas-Independence, Independence, Kansas, United States
Cancer Center of Kansas, PA - Kingman, Kingman, Kansas, United States
Lawrence Memorial Hospital, Lawrence, Kansas, United States
Southwest Medical Center, Liberal, Kansas, United States
Cancer Center of Kansas, PA - Newton, Newton, Kansas, United States
Menorah Medical Center, Overland Park, Kansas, United States
Cancer Center of Kansas, PA - Parsons, Parsons, Kansas, United States
Cancer Center of Kansas, PA - Pratt, Pratt, Kansas, United States
Cancer Center of Kansas, PA - Salina, Salina, Kansas, United States
Tammy Walker Cancer Center at Salina Regional Health Center, Salina, Kansas, United States
Shawnee Mission Medical Center, Shawnee Mission, Kansas, United States
Cotton-O'Neil Cancer Center, Topeka, Kansas, United States
St. Francis Comprehensive Cancer Center, Topeka, Kansas, United States
Cancer Center of Kansas, PA - Wellington, Wellington, Kansas, United States
Associates in Womens Health, PA - North Review, Wichita, Kansas, United States
Cancer Center of Kansas, PA - Medical Arts Tower, Wichita, Kansas, United States
Cancer Center of Kansas, PA - Wichita, Wichita, Kansas, United States
CCOP - Wichita, Wichita, Kansas, United States
Via Christi Cancer Center at Via Christi Regional Medical Center, Wichita, Kansas, United States
Wesley Medical Center, Wichita, Kansas, United States
Cancer Center of Kansas, PA - Winfield, Winfield, Kansas, United States
Pennington Cancer Center at Baton Rouge General, Baton Rouge, Louisiana, United States
Mary Bird Perkins Cancer Center - Baton Rouge, Baton Rouge, Louisiana, United States
Ochsner Health Center - Bluebonnet, Baton Rouge, Louisiana, United States
Ochsner Health Center - Covington, Covington, Louisiana, United States
Terrebonne General Medical Center, Houma, Louisiana, United States
MBCCOP - LSU Health Sciences Center, New Orleans, Louisiana, United States
Medical Center of Louisiana - New Orleans, New Orleans, Louisiana, United States
CCOP - Ochsner, New Orleans, Louisiana, United States
Ochsner Cancer Institute at Ochsner Clinic Foundation, New Orleans, Louisiana, United States
Greenebaum Cancer Center at University of Maryland Medical Center, Baltimore, Maryland, United States
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland, United States
Shore Regional Cancer Center at Memorial Hospital - Easton, Easton, Maryland, United States
Union Hospital Cancer Program at Union Hospital, Elkton, Maryland, United States
Associates in Oncology and Hematology, Kensington, Maryland, United States
Associates in Oncology and Hematology - Medical Center Drive, Rockville, Maryland, United States
Tufts-NEMC Cancer Center, Boston, Massachusetts, United States
Massachusetts General Hospital, Boston, Massachusetts, United States
Dana-Farber/Brigham and Women's Cancer Center, Boston, Massachusetts, United States
Dana-Farber/Harvard Cancer Center at Dana Farber Cancer Institute, Boston, Massachusetts, United States
Boston University Cancer Research Center, Boston, Massachusetts, United States
Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States
Caritas St. Elizabeth's Medical Center, Brighton, Massachusetts, United States
Lahey Clinic Medical Center - Burlington, Burlington, Massachusetts, United States
Hudner Oncology Center at Saint Anne's Hospital - Fall River, Fall River, Massachusetts, United States
Addison Gilbert Hospital, Gloucester, Massachusetts, United States
Cape Cod Hospital, Hyannis, Massachusetts, United States
Lowell General Hospital, Lowell, Massachusetts, United States
Berkshire Hematology Oncology, PC, Pittsfield, Massachusetts, United States
South Shore Hospital, South Weymouth, Massachusetts, United States
Morton Hospital & Medical Center, Taunton, Massachusetts, United States
Hickman Cancer Center at Bixby Medical Center, Adrian, Michigan, United States
Saint Joseph Mercy Cancer Center, Ann Arbor, Michigan, United States
CCOP - Michigan Cancer Research Consortium, Ann Arbor, Michigan, United States
University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan, United States
Battle Creek Health System Cancer Care Center, Battle Creek, Michigan, United States
Bay Regional Medical Center, Bay City, Michigan, United States
Mecosta County Medical Center, Big Rapids, Michigan, United States
Oakwood Cancer Center at Oakwood Hospital and Medical Center, Dearborn, Michigan, United States
Green Bay Oncology, Limited - Escanaba, Escanaba, Michigan, United States
Genesys Hurley Cancer Institute, Flint, Michigan, United States
Hurley Medical Center, Flint, Michigan, United States
Butterworth Hospital at Spectrum Health, Grand Rapids, Michigan, United States
CCOP - Grand Rapids, Grand Rapids, Michigan, United States
Lacks Cancer Center at Saint Mary's Health Care, Grand Rapids, Michigan, United States
Van Elslander Cancer Center at St. John Hospital and Medical Center, Grosse Pointe Woods, Michigan, United States
Dickinson County Healthcare System, Iron Mountain, Michigan, United States
Foote Memorial Hospital, Jackson, Michigan, United States
Borgess Medical Center, Kalamazoo, Michigan, United States
West Michigan Cancer Center, Kalamazoo, Michigan, United States
Bronson Methodist Hospital, Kalamazoo, Michigan, United States
Haematology-Oncology Associates of Ohio and Michigan, PC, Lambertville, Michigan, United States
Sparrow Regional Cancer Center, Lansing, Michigan, United States
St. Mary Mercy Hospital, Livonia, Michigan, United States
Community Cancer Center of Monroe, Monroe, Michigan, United States
Mercy Memorial Hospital - Monroe, Monroe, Michigan, United States
Mercy General Health Partners, Muskegon, Michigan, United States
St. Joseph Mercy Oakland, Pontiac, Michigan, United States
Mercy Regional Cancer Center at Mercy Hospital, Port Huron, Michigan, United States
William Beaumont Hospital - Royal Oak Campus, Royal Oak, Michigan, United States
Seton Cancer Institute at Saint Mary's - Saginaw, Saginaw, Michigan, United States
Lakeland Regional Cancer Care Center - St. Joseph, Saint Joseph, Michigan, United States
Oncology Care Associates, PLLC, Saint Joseph, Michigan, United States
Munson Medical Center, Traverse City, Michigan, United States
St. John Macomb Hospital, Warren, Michigan, United States
Metro Health Hospital, Wyoming, Michigan, United States
, Alexandria, Minnesota, United States
Fairview Ridges Hospital, Burnsville, Minnesota, United States
Mercy and Unity Cancer Center at Mercy Hospital, Coon Rapids, Minnesota, United States
Duluth Clinic Cancer Center - Duluth, Duluth, Minnesota, United States
CCOP - Duluth, Duluth, Minnesota, United States
Miller - Dwan Medical Center, Duluth, Minnesota, United States
Fairview Southdale Hospital, Edina, Minnesota, United States
, Fergus Falls, Minnesota, United States
Mercy and Unity Cancer Center at Unity Hospital, Fridley, Minnesota, United States
Hutchinson Area Health Care, Hutchinson, Minnesota, United States
Meeker County Memorial Hospital, Litchfield, Minnesota, United States
HealthEast Cancer Care at St. John's Hospital, Maplewood, Minnesota, United States
Minnesota Oncology Hematology, PA - Maplewood, Maplewood, Minnesota, United States
Virginia Piper Cancer Institute at Abbott - Northwestern Hospital, Minneapolis, Minnesota, United States
Hennepin County Medical Center - Minneapolis, Minneapolis, Minnesota, United States
Masonic Cancer Center at University of Minnesota, Minneapolis, Minnesota, United States
Hubert H. Humphrey Cancer Center at North Memorial Outpatient Center, Robbinsdale, Minnesota, United States
Mayo Clinic Cancer Center, Rochester, Minnesota, United States
CentraCare Clinic - River Campus, Saint Cloud, Minnesota, United States
Coborn Cancer Center, Saint Cloud, Minnesota, United States
CCOP - Metro-Minnesota, Saint Louis Park, Minnesota, United States
Park Nicollet Cancer Center, Saint Louis Park, Minnesota, United States
Regions Hospital Cancer Care Center, Saint Paul, Minnesota, United States
HealthEast Cancer Care at St. Joseph's Hospital, Saint Paul, Minnesota, United States
United Hospital, Saint Paul, Minnesota, United States
St. Francis Cancer Center at St. Francis Medical Center, Shakopee, Minnesota, United States
Ridgeview Medical Center, Waconia, Minnesota, United States
Willmar Cancer Center at Rice Memorial Hospital, Willmar, Minnesota, United States
HealthEast Cancer Care at Woodwinds Health Campus, Woodbury, Minnesota, United States
Minnesota Oncology Hematology, PA - Woodbury, Woodbury, Minnesota, United States
Hattiesburg Clinic, PA at Forrest General, Hattiesburg, Mississippi, United States
Hematology & Oncology Clinic, Hattiesburg, Mississippi, United States
Regional Cancer Center at Singing River Hospital, Pascagoula, Mississippi, United States
Ellis Fischel Cancer Center at University of Missouri - Columbia, Columbia, Missouri, United States
Independence Regional Health Center, Independence, Missouri, United States
Truman Medical Center - Hospital Hill, Kansas City, Missouri, United States
Saint Luke's Cancer Institute at Saint Luke's Hospital, Kansas City, Missouri, United States
St. Joseph Medical Center, Kansas City, Missouri, United States
North Kansas City Hospital, Kansas City, Missouri, United States
Parvin Radiation Oncology, Kansas City, Missouri, United States
CCOP - Kansas City, Kansas City, Missouri, United States
Research Medical Center, Kansas City, Missouri, United States
Liberty Hospital, Liberty, Missouri, United States
Heartland Regional Medical Center, Saint Joseph, Missouri, United States
Missouri Baptist Cancer Center, Saint Louis, Missouri, United States
Christian Hospital Northeast Cancer Care Center, Saint Louis, Missouri, United States
Arch Medical Services, Incorporated at Center for Cancer Care and Research, Saint Louis, Missouri, United States
CCOP - Cancer Research for the Ozarks, Springfield, Missouri, United States
St. John's Regional Health Center, Springfield, Missouri, United States
Hulston Cancer Center at Cox Medical Center South, Springfield, Missouri, United States
CCOP - Montana Cancer Consortium, Billings, Montana, United States
Hematology-Oncology Centers of the Northern Rockies - Billings, Billings, Montana, United States
Northern Rockies Radiation Oncology Center, Billings, Montana, United States
St. Vincent Healthcare Cancer Care Services, Billings, Montana, United States
Billings Clinic - Downtown, Billings, Montana, United States
St. James Healthcare Cancer Care, Butte, Montana, United States
Big Sky Oncology, Great Falls, Montana, United States
Great Falls Clinic - Main Facility, Great Falls, Montana, United States
Sletten Cancer Institute at Benefis Healthcare, Great Falls, Montana, United States
, Great Falls, Montana, United States
Northern Montana Hospital, Havre, Montana, United States
Glacier Oncology, PLLC, Kalispell, Montana, United States
Kalispell Medical Oncology at KRMC, Kalispell, Montana, United States
Kalispell Regional Medical Center, Kalispell, Montana, United States
Community Medical Center, Missoula, Montana, United States
Guardian Oncology and Center for Wellness, Missoula, Montana, United States
Montana Cancer Specialists at Montana Cancer Center, Missoula, Montana, United States
Montana Cancer Center at St. Patrick Hospital and Health Sciences Center, Missoula, Montana, United States
Good Samaritan Cancer Center at Good Samaritan Hospital, Kearney, Nebraska, United States
Cancer Resource Center - Lincoln, Lincoln, Nebraska, United States
CCOP - Missouri Valley Cancer Consortium, Omaha, Nebraska, United States
Methodist Estabrook Cancer Center, Omaha, Nebraska, United States
Immanuel Medical Center, Omaha, Nebraska, United States
Alegant Health Cancer Center at Bergan Mercy Medical Center, Omaha, Nebraska, United States
Creighton University Medical Center, Omaha, Nebraska, United States
University Medical Center of Southern Nevada, Las Vegas, Nevada, United States
CCOP - Nevada Cancer Research Foundation, Las Vegas, Nevada, United States
Elliot Regional Cancer Center at Elliot Hospital, Manchester, New Hampshire, United States
John F. Kennedy Medical Center, Edison, New Jersey, United States
CentraState Medical Center, Freehold, New Jersey, United States
St. Barnabas Medical Center Cancer Center, Livingston, New Jersey, United States
Fox Chase Virtua Health Cancer Program at Virtua Memorial Hospital Marlton, Marlton, New Jersey, United States
Carol G. Simon Cancer Center at Morristown Memorial Hospital, Morristown, New Jersey, United States
Cancer Institute of New Jersey at UMDNJ - Robert Wood Johnson Medical School, New Brunswick, New Jersey, United States
Overlook Hospital, Summit, New Jersey, United States
Franklin & Edith Scarpa Regional Cancer Center at South Jersey Healthcare, Vineland, New Jersey, United States
Cancer Institute of New Jersey at Cooper - Voorhees, Voorhees, New Jersey, United States
Fox Chase Virtua Health Cancer Program at Virtua West Jersey, Voorhees, New Jersey, United States
Our Lady of Mercy Medical Center Comprehensive Cancer Center, Bronx, New York, United States
Kings County Hospital Center, Brooklyn, New York, United States
SUNY Downstate Medical Center, Brooklyn, New York, United States
Veterans Affairs Medical Center - Buffalo, Buffalo, New York, United States
CCOP - Hematology-Oncology Associates of Central New York, East Syracuse, New York, United States
Ralph Lauren Center for Cancer Care and Prevention, New York, New York, United States
Memorial Sloan-Kettering Cancer Center, New York, New York, United States
James P. Wilmot Cancer Center at University of Rochester Medical Center, Rochester, New York, United States
Nalitt Cancer Institute at Staten Island University Hospital, Staten Island, New York, United States
SUNY Upstate Medical University Hospital, Syracuse, New York, United States
Mission Hospitals - Memorial Campus, Asheville, North Carolina, United States
Lineberger Comprehensive Cancer Center at University of North Carolina - Chapel Hill, Chapel Hill, North Carolina, United States
Blumenthal Cancer Center at Carolinas Medical Center, Charlotte, North Carolina, United States
Presbyterian Cancer Center at Presbyterian Hospital, Charlotte, North Carolina, United States
Wayne Memorial Hospital, Incorporated, Goldsboro, North Carolina, United States
Leo W. Jenkins Cancer Center at ECU Medical School, Greenville, North Carolina, United States
Kinston Medical Specialists, Kinston, North Carolina, United States
FirstHealth Moore Regional Community Hospital Comprehensive Cancer Center, Pinehurst, North Carolina, United States
Rutherford Hospital, Rutherfordton, North Carolina, United States
Wake Forest University Comprehensive Cancer Center, Winston-Salem, North Carolina, United States
Bismarck Cancer Center, Bismarck, North Dakota, United States
Medcenter One Hospital Cancer Care Center, Bismarck, North Dakota, United States
Mid Dakota Clinic, PC, Bismarck, North Dakota, United States
St. Alexius Medical Center Cancer Center, Bismarck, North Dakota, United States
Dakota Cancer Institute at Dakota Clinic - South University, Fargo, North Dakota, United States
Altru Cancer Center at Altru Hospital, Grand Forks, North Dakota, United States
McDowell Cancer Center at Akron General Medical Center, Akron, Ohio, United States
Summa Center for Cancer Care at Akron City Hospital, Akron, Ohio, United States
Mary Rutan Hospital, Bellefontaine, Ohio, United States
Wood County Oncology Center, Bowling Green, Ohio, United States
Aultman Cancer Center at Aultman Hospital, Canton, Ohio, United States
Adena Regional Medical Center, Chillicothe, Ohio, United States
MetroHealth Cancer Care Center at MetroHealth Medical Center, Cleveland, Ohio, United States
North Coast Cancer Care - Clyde, Clyde, Ohio, United States
Arthur G. James Cancer Hospital and Solove Research Institute at Ohio State University Medical Center, Columbus, Ohio, United States
Riverside Methodist Hospital Cancer Care, Columbus, Ohio, United States
CCOP - Columbus, Columbus, Ohio, United States
Grant Medical Center Cancer Care, Columbus, Ohio, United States
Mount Carmel Health - West Hospital, Columbus, Ohio, United States
Doctors Hospital at Ohio Health, Columbus, Ohio, United States
Grandview Hospital, Dayton, Ohio, United States
Good Samaritan Hospital, Dayton, Ohio, United States
Veterans Affairs Medical Center - Dayton, Dayton, Ohio, United States
CCOP - Dayton, Dayton, Ohio, United States
Grady Memorial Hospital, Delaware, Ohio, United States
Hematology Oncology Center, Elyria, Ohio, United States
Blanchard Valley Medical Associates, Findlay, Ohio, United States
Middletown Regional Hospital, Franklin, Ohio, United States
Charles F. Kettering Memorial Hospital, Kettering, Ohio, United States
Fairfield Medical Center, Lancaster, Ohio, United States
St. Rita's Medical Center, Lima, Ohio, United States
Lima Memorial Hospital, Lima, Ohio, United States
Strecker Cancer Center at Marietta Memorial Hospital, Marietta, Ohio, United States
Northwest Ohio Oncology Center, Maumee, Ohio, United States
St. Luke's Hospital, Maumee, Ohio, United States
Licking Memorial Cancer Care Program at Licking Memorial Hospital, Newark, Ohio, United States
St. Charles Mercy Hospital, Oregon, Ohio, United States
Toledo Clinic - Oregon, Oregon, Ohio, United States
Cancer Research UK Medical Oncology Unit at Churchill Hospital & Weatherall Institute of Molecular Medicine - Oxford, Salem, Ohio, United States
North Coast Cancer Care, Incorporated, Sandusky, Ohio, United States
Mercy Medical Center, Springfield, Ohio, United States
Community Hospital of Springfield and Clark County, Springfield, Ohio, United States
Flower Hospital Cancer Center, Sylvania, Ohio, United States
Mercy Hospital of Tiffin, Tiffin, Ohio, United States
Toledo Hospital, Toledo, Ohio, United States
St. Vincent Mercy Medical Center, Toledo, Ohio, United States
Medical University of Ohio Cancer Center, Toledo, Ohio, United States
CCOP - Toledo Community Hospital, Toledo, Ohio, United States
St. Anne Mercy Hospital, Toledo, Ohio, United States
Toledo Clinic, Incorporated - Main Clinic, Toledo, Ohio, United States
UVMC Cancer Care Center at Upper Valley Medical Center, Troy, Ohio, United States
Fulton County Health Center, Wauseon, Ohio, United States
Mount Carmel St. Ann's Cancer Center, Westerville, Ohio, United States
Clinton Memorial Hospital, Wilmington, Ohio, United States
Cancer Treatment Center, Wooster, Ohio, United States
Ruth G. McMillan Cancer Center at Greene Memorial Hospital, Xenia, Ohio, United States
Genesis - Good Samaritan Hospital, Zanesville, Ohio, United States
Cleo Craig Cancer Research Clinic, Lawton, Oklahoma, United States
Oklahoma University Cancer Institute, Oklahoma City, Oklahoma, United States
Cancer Care Associates - Mercy Campus, Oklahoma City, Oklahoma, United States
Kaiser Permanente Health Care - Portland, Portland, Oregon, United States
Salem Hospital Regional Cancer Care Services, Salem, Oregon, United States
Morgan Cancer Center at Lehigh Valley Hospital - Cedar Crest, Allentown, Pennsylvania, United States
UPMC Cancer Center at Beaver Medical Center, Beaver, Pennsylvania, United States
St. Luke's Cancer Network at St. Luke's Hospital, Bethlehem, Pennsylvania, United States
Bryn Mawr Hospital, Bryn Mawr, Pennsylvania, United States
UPMC Cancer Center at Jefferson Regional Medical Center, Clairton, Pennsylvania, United States
Geisinger Cancer Institute at Geisinger Health, Danville, Pennsylvania, United States
Oncology Hematology Associates of Northern Pennsylvania, PC at Hahne Regional Cancer Center, DuBois, Pennsylvania, United States
Dale and Frances Hughes Cancer Center at Pocono Medical Center, East Stroudsburg, Pennsylvania, United States
Easton Regional Cancer Center at Easton Hospital, Easton, Pennsylvania, United States
UPMC Cancer Center - Arnold Palmer Pavilion, Greensburg, Pennsylvania, United States
Penn State Cancer Institute at Milton S. Hershey Medical Center, Hershey, Pennsylvania, United States
UPMC Cancer Center at the John P. Murtha Pavilion, Johnstown, Pennsylvania, United States
St. Mary Regional Cancer Center, Langhorne, Pennsylvania, United States
Lewistown Hospital, Lewistown, Pennsylvania, United States
Riddle Memorial Hospital Cancer Center, Media, Pennsylvania, United States
UPMC - Moon, Moon, Pennsylvania, United States
UPMC Cancer Center - Natrona Heights, Natrona Heights, Pennsylvania, United States
Jameson Memorial Hospital - North Campus, New Castle, Pennsylvania, United States
Cancer Center of Paoli Memorial Hospital, Paoli, Pennsylvania, United States
Abramson Cancer Center of the University of Pennsylvania, Philadelphia, Pennsylvania, United States
Kimmel Cancer Center at Thomas Jefferson University - Philadelphia, Philadelphia, Pennsylvania, United States
Joan Karnell Cancer Center at Pennsylvania Hospital, Philadelphia, Pennsylvania, United States
Fox Chase Cancer Center - Philadelphia, Philadelphia, Pennsylvania, United States
Frankford Hospital Cancer Center - Torresdale Campus, Philadelphia, Pennsylvania, United States
Albert Einstein Cancer Center, Philadelphia, Pennsylvania, United States
UPMC - Shadyside, Pittsburgh, Pennsylvania, United States
UPMC Cancer Center at UPMC St. Margaret, Pittsburgh, Pennsylvania, United States
Mercy Cancer Institute at Mercy Hospital, Pittsburgh, Pennsylvania, United States
UPMC Cancer Centers, Pittsburgh, Pennsylvania, United States
UPMC Cancer Center at UPMC Passavant, Pittsburgh, Pennsylvania, United States
St. Clair Memorial Hospital Cancer Center, Pittsburgh, Pennsylvania, United States
Guthrie Cancer Center at Guthrie Clinic Sayre, Sayre, Pennsylvania, United States
Mercy Hospital Cancer Center - Scranton, Scranton, Pennsylvania, United States
Hematology and Oncology Associates of Northeastern Pennsylvania, Scranton, Pennsylvania, United States
Grand View Hospital, Sellersville, Pennsylvania, United States
UPMC Cancer Center at UPMC Northwest, Seneca, Pennsylvania, United States
Geisinger Medical Group - Scenery Park, State College, Pennsylvania, United States
Mount Nittany Medical Center, State College, Pennsylvania, United States
Washington Hospital Cancer Center, Washington, Pennsylvania, United States
Jennersville Regional Hospital, West Grove, Pennsylvania, United States
Frank M. and Dorothea Henry Cancer Center at Geisinger Wyoming Valley Medical Center, Wilkes-Barre, Pennsylvania, United States
CCOP - Main Line Health, Wynnewood, Pennsylvania, United States
Lankenau Cancer Center at Lankenau Hospital, Wynnewood, Pennsylvania, United States
Hematology and Oncology Associates of Rhode Island, Cranston, Rhode Island, United States
Memorial Hospital of Rhode Island, Pawtucket, Rhode Island, United States
Kent County Memorial Hospital, Warwick, Rhode Island, United States
AnMed Cancer Center, Anderson, South Carolina, United States
Roper St. Francis Cancer Center at Roper Hospital, Charleston, South Carolina, United States
CCOP - Greenville, Greenville, South Carolina, United States
CCOP - Upstate Carolina, Spartanburg, South Carolina, United States
Gibbs Regional Cancer Center at Spartanburg Regional Medical Center, Spartanburg, South Carolina, United States
Avera Cancer Institute, Sioux Falls, South Dakota, United States
Medical X-Ray Center, PC, Sioux Falls, South Dakota, United States
Sanford Cancer Center at Sanford USD Medical Center, Sioux Falls, South Dakota, United States
Blue Ridge Medical Specialists, PC, Bristol, Tennessee, United States
Christine LaGuardia Phillips Cancer Center at Wellmont Holston Valley Medical Center, Kingsport, Tennessee, United States
Thompson Cancer Survival Center, Knoxville, Tennessee, United States
Brooke Army Medical Center, Fort Sam Houston, Texas, United States
Wilford Hall Medical Center, Lackland Air Force Base, Texas, United States
Doctor's Hospital of Laredo, Laredo, Texas, United States
CCOP - Scott and White Hospital, Temple, Texas, United States
American Fork Hospital, American Fork, Utah, United States
Sandra L. Maxwell Cancer Center, Cedar City, Utah, United States
Jon and Karen Huntsman Cancer Center at Intermountain Medical Center, Murray, Utah, United States
Val and Ann Browning Cancer Center at McKay-Dee Hospital Center, Ogden, Utah, United States
Utah Valley Regional Medical Center - Provo, Provo, Utah, United States
Dixie Regional Medical Center - East Campus, Saint George, Utah, United States
LDS Hospital, Salt Lake City, Utah, United States
Utah Cancer Specialists at UCS Cancer Center, Salt Lake City, Utah, United States
Huntsman Cancer Institute at University of Utah, Salt Lake City, Utah, United States
Danville Regional Medical Center, Danville, Virginia, United States
Fredericksburg Oncology, Incorporated, Fredericksburg, Virginia, United States
Virginia Oncology Associates - Hampton, Hampton, Virginia, United States
Lynchburg Hematology-Oncology Clinic, Lynchburg, Virginia, United States
Southwest Virginia Regional Cancer Center at Wellmonth Health, Norton, Virginia, United States
Virginia Commonwealth University Massey Cancer Center, Richmond, Virginia, United States
St. Joseph Cancer Center, Bellingham, Washington, United States
Olympic Hematology and Oncology, Bremerton, Washington, United States
Columbia Basin Hematology, Kennewick, Washington, United States
Fred Hutchinson Cancer Research Center, Seattle, Washington, United States
Harborview Medical Center, Seattle, Washington, United States
Minor and James Medical, PLLC, Seattle, Washington, United States
Group Health Central Hospital, Seattle, Washington, United States
Swedish Cancer Institute at Swedish Medical Center - First Hill Campus, Seattle, Washington, United States
Polyclinic First Hill, Seattle, Washington, United States
University Cancer Center at University of Washington Medical Center, Seattle, Washington, United States
Cancer Care Northwest - Spokane South, Spokane, Washington, United States
Madigan Army Medical Center - Tacoma, Tacoma, Washington, United States
West Virginia University Health Sciences Center - Charleston, Charleston, West Virginia, United States
Edwards Comprehensive Cancer Center at Cabell Huntington Hospital, Huntington, West Virginia, United States
Community Comprehensive Cancer Center at Camden-Clark Memorial Hospital, Parkersburg, West Virginia, United States
Princeton Community Hospital, Princeton, West Virginia, United States
Marshfield Clinic Cancer Care at Regional Cancer Center, Eau Claire, Wisconsin, United States
Green Bay Oncology, Limited at St. Vincent Hospital Regional Cancer Center, Green Bay, Wisconsin, United States
Green Bay Oncology, Limited at St. Mary's Hospital, Green Bay, Wisconsin, United States
St. Mary's Hospital Medical Center - Green Bay, Green Bay, Wisconsin, United States
St. Vincent Hospital Regional Cancer Center, Green Bay, Wisconsin, United States
Bay Area Cancer Care Center at Bay Area Medical Center, Marinette, Wisconsin, United States
Marshfield Clinic - Marshfield Center, Marshfield, Wisconsin, United States
Medical College of Wisconsin Cancer Center, Milwaukee, Wisconsin, United States
Marshfield Clinic - Lakeland Center, Minocqua, Wisconsin, United States
Regional Cancer Center at Oconomowoc Memorial Hospital, Oconomowoc, Wisconsin, United States
Green Bay Oncology, Limited - Oconto Falls, Oconto Falls, Wisconsin, United States
Ministry Medical Group at Saint Mary's Hospital, Rhinelander, Wisconsin, United States
Marshfield Clinic - Indianhead Center, Rice Lake, Wisconsin, United States
Green Bay Oncology, Limited - Sturgeon Bay, Sturgeon Bay, Wisconsin, United States
Waukesha Memorial Hospital Regional Cancer Center, Waukesha, Wisconsin, United States
Marshfield Clinic - Weston Center, Weston, Wisconsin, United States
Marshfield Clinic - Wisconsin Rapids Center, Wisconsin Rapids, Wisconsin, United States
Cross Cancer Institute at University of Alberta, Edmonton, Alberta, Canada
CancerCare Manitoba, Winnipeg, Manitoba, Canada
Saint John Regional Hospital, Saint John, New Brunswick, Canada
Margaret and Charles Juravinski Cancer Centre, Hamilton, Ontario, Canada
Cancer Centre of Southeastern Ontario at Kingston General Hospital, Kingston, Ontario, Canada
London Regional Cancer Program at London Health Sciences Centre, London, Ontario, Canada
Ottawa Hospital Regional Cancer Centre - General Campus, Ottawa, Ontario, Canada
Allan Blair Cancer Centre at Pasqua Hospital, Regina, Saskatchewan, Canada
Contact Details
Name: Charles Fuchs, MD, MPH
Affiliation: Dana-Farber Cancer Institute
Role: STUDY_CHAIR
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