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Spots Global Cancer Trial Database for ADP-A2M4CD8 in HLA-A2+ Subjects With MAGE-A4 Positive Esophageal or Esophagogastric Junction Cancers (SURPASS-2)

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Trial Identification

Brief Title: ADP-A2M4CD8 in HLA-A2+ Subjects With MAGE-A4 Positive Esophageal or Esophagogastric Junction Cancers (SURPASS-2)

Official Title: A Phase 2 Open-Label Clinical Trial of ADP-A2M4CD8 in Subjects With Advanced Esophageal or Esophagogastric Junction Cancers

Study ID: NCT04752358

Study Description

Brief Summary: This study will investigate the efficacy of ADP-A2M4CD8 T-cell therapy in subjects who have the appropriate human leukocyte antigen (HLA) and tumor antigen status and whose esophageal or esophagogastric junction (EGJ) cancer expresses the MAGE-A4 protein.

Detailed Description:

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: No

Locations

City of Hope National Medical Center, Duarte, California, United States

University of Chicago Medicine, Chicago, Illinois, United States

Washington University School of Medicine- Siteman Cancer Center, Saint Louis, Missouri, United States

Memorial Sloan Kettering Cancer Center, New York, New York, United States

OU Health Stephenson Cancer Center, Oklahoma City, Oklahoma, United States

Providence Cancer Institute Franz Clinic, Portland, Oregon, United States

University Of Texas, MD Anderson Cancer Center, Houston, Texas, United States

University Of Wisconsin Clinical Science Center, Madison, Wisconsin, United States

Princess Margaret Cancer Centre, Toronto, Ontario, Canada

McGill University Health Centre Glen Site, Montreal, Quebec, Canada

Hospital Universitari Vall d'Hebron, la Vall d'Hebron, Barcelona, Spain

Hospital Universitario 12 de Octubre, Córdoba, Madrid, Spain

Hospital Clinico Universitario de Valencia, Ibáñez, Valencia, Spain

Hospital Fundacion Jimenez Diaz, Madrid, , Spain

Hospital Universitario Madrid Sanchinarro (CIOCC), Madrid, , Spain

Clinica Universidad de Navarra, Navarro, , Spain

Hospital Universitario Virgen del Rocio, Sevilla, , Spain

Contact Details

Useful links and downloads for this trial

Clinicaltrials.gov

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