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Brief Title: Intravenous NTG to Preserve Gastric Microcirculation During Gastric Tube Reconstruction
Official Title: A Prospective Double Blinded Study on the Effect of Intravenously Administrated Nitroglycerine on Gastric Tissue Microvascular Bloodflow and Microvascular Hemoglobin Saturation During Gastric Tube Reconstruction
Study ID: NCT00335010
Brief Summary: The aim of the present study was to investigate if NTG, administered intravenously during gastric tube reconstruction, could preserve gastric fundus tissue blood flow and oxygenation and reduce the incidence of postoperative leakage.
Detailed Description: Complications of oesophagectomy and gastric tube reconstruction are leakage and stenosis, which may be due to compromised microvascular blood flow (MBF) in the gastric tissue. We recently demonstrated that peri-operatively decreased MBF could be improved by topical administration of nitro-glycerine NTG). In this present study we investigate the effect of intravenous NTG on gastric microcirculation. This single centre, prospective, double blinded study randomized thirty-two patients scheduled for esophagectomy into two groups. The intervention group received intravenous NTG during gastric tube reconstruction, as the control group received normal saline. Baseline values of MBF, microvascular haemoglobin O2 saturation (μHbSO2), and microvascular haemoglobin concentration (μHbcon) were determined at the gastric fundus before and after gastric tube construction and after pulling up the gastric tube to the neck.
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Erasmus MC, Rotterdam, , Netherlands
Name: Diederik Gommers, MD, PhD
Affiliation: Erasmus Medical Center
Role: STUDY_CHAIR
Name: Marc Buise, MD
Affiliation: Erasmus Medical Center
Role: PRINCIPAL_INVESTIGATOR
Name: Jasper van Bommel, MD, PhD
Affiliation: Erasmus Medical Center
Role: STUDY_DIRECTOR
Name: Huug Tilanus, MD, PhD
Affiliation: Erasmus Medical Center
Role: PRINCIPAL_INVESTIGATOR
Name: Khe Tran, MD
Affiliation: Erasmus Medical Center
Role: PRINCIPAL_INVESTIGATOR