Spots Global Cancer Trial Database for Pronase Improves Efficacy of Chromoendoscopy Screening on Esophageal Cancer
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Trial Identification
Brief Title: Pronase Improves Efficacy of Chromoendoscopy Screening on Esophageal Cancer
Official Title: Pronase Improves Efficacy of Chromoendoscopy Screening on Esophageal Cancer
Study ID: NCT02030769
Conditions
Study Description
Brief Summary: Lugol's solution staining was regarded as a gold standard to detect early superficial lesion during esophageal cancer screening using endoscopy. However, the sensitivity and specificity were influenced by mucus and food debris of esophagus. Pronase, a kind of protease, was previously shown to improve the visibility of gastrointestinal tract. It's unknown if the pre-treatment with pronase would also improve the quality of iodine staining in esophagus.A randomized double-blind clinical trial was designed to investigate whether or not pronase might improve detection rate of early esophageal lesion, especially high grade dysplasia and early cancer by improving the esophageal visibility.
Detailed Description:
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: Yes
Locations
Xijing Hospital of Digestive Disease, Xi'an, Shaanxi, China
Contact Details
Name: Kaichun Wu, Ph.D. & M.D.
Affiliation: Xijing Hospital of Digestive DIsease
Role: STUDY_CHAIR
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