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Brief Title: The Tetrad BMI, Leptin, Leptin/Adiponectin (L/A) Ratio and CA-15-3 is a Reliable Biomarker of Breast Cancer
Official Title: Phase 1. Collect Samples of Breast Biopsy Patients Treated at the Hospital Radiology Service Maternal Perinatal Monica Pretelini
Study ID: NCT01643148
Brief Summary: Objective: Evaluate body mass index (BMI), leptin, Leptin/adiponectin (L/A) ratio and cancer antigen (CA) 15-3 together as reliable biomarkers for breast cancer. Patients: Consecutive patients aged between 40 - 60 years, with breast disease and informed consent. Interventions: Patients' Anthropometric and laboratorial characteristics classified by BMI in the group of cancer and patients with benign breast disease as well as biochemical tests of leptin, adiponectin,CA 15-3, hemoglobin, glucose low-density lipoprotein cholesterol (LDLC), high-density lipoprotein cholesterol (HDLC) levels were obtained as well as a blood sample to analyze CA 15-3 levels with a electrochemiluminescence immunoassay. Hypothesis: Using together leptin, L/A ratio, CA 15-3 and BMI could offer a reliable approach to detect high risk women to develop breast cancer.
Detailed Description: Serum levels of leptin, adiponectin and CA 15-3, as well as anthropometric and biochemical parameters were analyzed in 88 female patients attending mammography study. Predictive values of BMI, leptin, L/A ratio and CA 15-3 were determined with 95% confidence interval (CI).
Minimum Age: 40 Years
Eligible Ages: ADULT
Sex: FEMALE
Healthy Volunteers: No
Name: Jonnathan Guadalupe Santillán Benítez, MSc
Affiliation: Autonomus University Of the State Of México
Role: PRINCIPAL_INVESTIGATOR
Name: Leobardo Manuel Gómez Oliván, PhD
Affiliation: Universidad Autonoma del Estado de Mexico
Role: STUDY_DIRECTOR
Name: Hugo Mendieta Zeron, PhD
Affiliation: Autonomous University of the State of Mexico
Role: STUDY_CHAIR