Spots Global Cancer Trial Database for Effect of Acetazolamide & Position in CSF Leakage and Collection and Wound Dehiscence

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Trial Identification

Brief Title: Effect of Acetazolamide & Position in CSF Leakage and Collection and Wound Dehiscence

Official Title: Evaluating the Effect of Acetazolamide Administration and Prone Positioning Following Lumbosacral Spinal Surgery in Preventing Cerebro Spinal Fluid Leakage and Collection and Wound Dehiscence in Children.

Study ID: NCT01867268

Conditions

Fibrolipoma of Filum Terminale

Lipomyelomeningocele

Split Cord Malformation

Dermal Sinus

Tethered Cord Syndrome

Tumor

Interventions

Acetazolamide

prone positioning

Acetazolamide+ prone positioning

Study Description

Brief Summary: * Purpose of study : to determine the preventive effect of acetazolamide administration, prone positioning, and the combination of both following the neurosurgical interventions in lumbosacral region for cerebrospinal fluid (CSF) leak, CSF collection and wound dehiscence. * Sample size: 144 * intervention groups: * Group A: Acetazolamide administration for 10 days * Group B: prone positioning for 10 days * Group C: Acetazolamide administration and prone positioning for 10 days * Group D: no intervention * Period of study: Autumn 2012 to the end of winter of 2015

Detailed Description: The purpose of this study is to evaluate the effect of Acetazolamide administration and prone positioning following lumbosacral spinal surgery in preventing cerebro-spinal fluid leakage and collection and wound dehissence in children admitted to Children Medical Center of Tehran since Autumn 2012 to the end of winter of 2015.The study is run under 4 categories of intervention: * Group A: Acetazolamide administration for 10 days * Group B: prone positioning for 10 days * Group C: Acetazolamide administration and prone positioning for 10 days * Group D: no intervention All patients are randomly assigned to these groups and when the patients faced with any of these complications, the protocol changes to Acetazolamide administration and prone positioning and the patient is considered as the failure of the protocol.