Wounds and Injuries

All Conditions

Symptoms and General Pathology

Diseases and Abnormalities at or Before Birth

Nervous System Diseases

Rare Diseases

Syndrome

Congenital Abnormalities

Cerebrospinal Fluid Leak

Spinal Dysraphism

Neural Tube Defects

Spina Bifida Occulta

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Tethered Cord Syndrome

Split Spinal Cord Malformation

Lipomyelomeningocele

Spina Bifida

Natriuretic Agents

Anticonvulsants

All Drugs and Chemicals

Acetazolamide

Carbonic Anhydrase Inhibitors

Enzyme Inhibitors

Diuretics

administration of Acetazolamide for 10 days following the surgery

Positioning the patient following surgery for 10 days

applying both Acetazolamide and prone positioning

Acetazolamide administration for 10 days adjust dosage with weight of the patient

prone positioning the patient for 10 days following the surgery

prone positioning

administration of acetazolamide and position the patient for 10 days following the surgery

Acetazolamide+ prone positioning

Farideh Nejat, MD

Shima Shahjouei, Student

* Purpose of study : to determine the preventive effect of acetazolamide administration, prone positioning, and the combination of both following the neurosurgical interventions in lumbosacral region for cerebrospinal fluid (CSF) leak, CSF collection and wound dehiscence.
* Sample size: 144
* intervention groups:

  * Group A: Acetazolamide administration for 10 days
  * Group B: prone positioning for 10 days
  * Group C: Acetazolamide administration and prone positioning for 10 days
  * Group D: no intervention
* Period of study: Autumn 2012 to the end of winter of 2015

The purpose of this study is to evaluate the effect of Acetazolamide administration and prone positioning following lumbosacral spinal surgery in preventing cerebro-spinal fluid leakage and collection and wound dehissence in children admitted to Children Medical Center of Tehran since Autumn 2012 to the end of winter of 2015.The study is run under 4 categories of intervention:

* Group A: Acetazolamide administration for 10 days
* Group B: prone positioning for 10 days
* Group C: Acetazolamide administration and prone positioning for 10 days
* Group D: no intervention All patients are randomly assigned to these groups and when the patients faced with any of these complications, the protocol changes to Acetazolamide administration and prone positioning and the patient is considered as the failure of the protocol.

Effect of Acetazolamide & Position in CSF Leakage and Collection and Wound Dehiscence

Evaluating the Effect of Acetazolamide Administration and Prone Positioning Following Lumbosacral Spinal Surgery in Preventing Cerebro Spinal Fluid Leakage and Collection and Wound Dehiscence in Children.

leakage of CSF during 1 months following surgery

collection of the CSF beneath the skin during 1 month following the surgery

dehiscence of the surgical wound during the first month following surgery

Tehran University of Medical Sciences

Neoplasms

Respiratory Tract (Lung and Bronchial) Diseases

Lung Neoplasms

Carcinoma

Neoplasm Metastasis

Small Cell Lung Carcinoma

Neoplasms, Second Primary

Brain Neoplasms

Respiratory Tract Neoplasms

Thoracic Neoplasms

Lung Diseases

Respiratory Tract Diseases

Neoplastic Processes

Carcinoma, Bronchogenic

Bronchial Neoplasms

Central Nervous System Neoplasms

Nervous System Neoplasms

Brain Diseases

Central Nervous System Diseases

Small Cell Lung Cancer

Participants may be newly diagnosed small cell lung cancer with brain metastases at initial staging, or can alternatively be patients who develop brain metastases on therapy or during surveillance of systemic disease.

All participants will undergo MSK standard SRS. A CT simulation will be performed per institutional standards, typically with contrast unless a contraindication exists. A contrast-enhanced MRI with 1mm slices will be fused to the CT simulation scan for the purposes of SRS planning. The SRS GTV will be considered the visible tumor on MRI and CT contrast enhanced studies. An expansion of 1-2mm will be used to create the PTV. Radiation dose may be between 16Gy and 30Gy in 1 to 5 fractions, per the discretion of the treating radiation oncologist. Participants with multiple lesions may receive different doses to each lesion per the discretion of the treating radiation oncologist. Concurrent treatment to other body sites is permitted.

Stereotactic Radiosurgery

All participants will undergo lumbar puncture for CSF collection at study enrollment.. Lumbar punctures will be performed by clinical staff in neurology or neuroradiology, per the discretion of the treating radiation oncologist, as dictated by scheduling limitations and expected clinical difficulty in obtaining a sample (e.g. requiring fluoroscopic guidance), with input from the PI, neurology, and/or neuroradiology as necessary. Participants will be encouraged to undergo repeat lumbar puncture for CSF collection at 3 months (+/- 4 weeks), and at the time of CNS disease progression, though these latter timepoints are not required. CSF cytology will be evaluated.

Cerebrospinal fluid collection

Luke Pike, MD

Brandon Imber, MD

The purpose of the study is to see if stereotactic radiosurgery/SRS is an effective treatment for people with a new diagnosis of brain metastases from small cell lung cancer/SCLC.

A Study of Stereotactic Radiosurgery (SRS) for People With Lung Cancer That Has Spread to the Brain

A Single Arm Phase II Study Assessing Efficacy of Stereotactic Radiosurgery (SRS) for Brain Metastasis (BM) From Small Cell Lung Cancer (SCLC)

Memorial Sloan Kettering Cancer Center supports the international committee of medical journal editors (ICMJE) and the ethical obligation of responsible sharing of data from clinical trials. The protocol summary, a statistical summary, and informed consent form will be made available on clinicaltrials.gov when required as a condition of Federal awards, other agreements supporting the research and/or as otherwise required. Requests for deidentified individual participant data can be made beginning 12 months after publication and for up to 36 months post publication. Deidentified individual participant data reported in the manuscript will be shared under the terms of a Data Use Agreement and may only be used for approved proposals. Requests may be made to: crdatashare@mskcc.org.

The primary endpoint of this study is the rate of overall survival at 6 months, with time measured from the start of SRS treatment. Participants will be censored at the date of last follow up or the last date the participant was known to be alive.

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Effect of Acetazolamide & Position in CSF Leakage and Collection and Wound Dehiscence	NCT01867268	Fibrolipoma of ... Lipomyelomening... Split Cord Malf... Dermal Sinus Tethered Cord S... Tumor	Acetazolamide prone positioni... Acetazolamide+ ...	- 18 Years	Tehran University of Medical Sciences
A Study of Stereotactic Radiosurgery (SRS) for People With Lung Cancer That Has Spread to the Brain	NCT05419076	Lung Cancer Lung Cancer Met... Brain Metastase... Brain Metastase... Small-cell Lung... Small Cell Lung...	Stereotactic Ra... Cerebrospinal f...	18 Years -	Memorial Sloan Kettering Cancer Center

Spots Global Cancer Trial Database for cerebrospinal fluid collection