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Spots Global Cancer Trial Database for ACP-196 (Acalabrutinib) in Combination With Pembrolizumab, for Treatment of Hematologic Malignancies

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Trial Identification

Brief Title: ACP-196 (Acalabrutinib) in Combination With Pembrolizumab, for Treatment of Hematologic Malignancies

Official Title: A Phase 1b/2 Proof-of-Concept Study of the Combination of ACP-196 (Acalabrutinib) and Pembrolizumab in Subjects With Hematologic Malignancies

Study ID: NCT02362035

Study Description

Brief Summary: This study is evaluating the safety, pharmacodynamics (PD), and efficacy of acalabrutinib and pembrolizumab in hematologic malignancies.

Detailed Description: This is a Phase 1b/2, open-label, nonrandomized study that will be conducted in 2 stages. In the first stage, Part 1 of the study will determine the safety and preliminary efficacy of acalabrutinib and pembrolizumab in a limited group of B-cell malignancies. In the second stage, Part 2 allows for possible expansion cohorts into a wider range of B-cell malignancies, and Part 3 will evaluate the combination in subjects with myelofibrosis (MF).

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: No

Locations

Research Site, Tucson, Arizona, United States

Research Site, Los Angeles, California, United States

Research Site, Denver, Colorado, United States

Research Site, Washington, District of Columbia, United States

Research Site, Niles, Illinois, United States

Research Site, Boston, Massachusetts, United States

Research Site, Rochester, Minnesota, United States

Research Site, Omaha, Nebraska, United States

Research Site, Columbus, Ohio, United States

Research Site, Greenville, South Carolina, United States

Research Site, Nashville, Tennessee, United States

Research Site, Dallas, Texas, United States

Research Site, Houston, Texas, United States

Research Site, San Antonio, Texas, United States

Research Site, Tyler, Texas, United States

Research Site, Fairfax, Virginia, United States

Research Site, Roanoke, Virginia, United States

Research Site, Vancouver, Washington, United States

Research Site, Yakima, Washington, United States

Contact Details

Name: AstraZeneca Clinical Study Information Center

Affiliation: 1-877-240-9479 - information.center@astrazeneca.com

Role: STUDY_DIRECTOR

Useful links and downloads for this trial

Clinicaltrials.gov

Google Search Results

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