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Spots Global Cancer Trial Database for First-line R-CVP vs R-CHOP Induction Immunochemotherapy for Indolent Lymphoma and R Maintenance.

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Trial Identification

Brief Title: First-line R-CVP vs R-CHOP Induction Immunochemotherapy for Indolent Lymphoma and R Maintenance.

Official Title: First-line R-CVP vs R-CHOP Induction Immunochemotherapy for Indolent Lymphoma and R Maintenance.A Multicentre, Phase III Randomized Study by the PLRG.

Study ID: NCT00801281

Study Description

Brief Summary: Evaluation of event free survival (EFS) of patients treated with the study chemotherapy induction program: R-CHOP compared to the standard R-CVP regimen and response rates, time to best response, PFS, OS, neutropenic fever rate, infection rate, change in Ig levels, change in lymphocyte subpopulations counts in previously untreated indolent lymphoma patients in need of systemic treatment.

Detailed Description: Min. 3, max. 8 induction cycles. Maintenance with rituximab q. 2 months x 12/24 months, started 2 months after last chemotherapy.

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: No

Locations

Podkarpacki Oncology Centre, Brzozów, , Poland

Voivodeship Hospital, Oncology Ward, Elbląg, , Poland

Academic Clinical Centre, Hospital of Medical Academy, Clinic of Haematology and Transplantology, Gdańsk, , Poland

Silesian Medical University, Chair and Clinic of Haematology and Bone Marrow Transplantation, Katowice, , Poland

Collegium Medicum Jagiellonian University, Clinic of Haematology, Kraków, , Poland

Oncology Centre of Lublin Region, Lublin, , Poland

Central Clinical Hospital, Ministry of Internal Matters and Administration; Clinic of Oncology, Haematology and Internal Diseases, Warszawa, , Poland

Institute of Haematology and Transfusiology, Warszawa, , Poland

M.Sklodowska-Curie Institute - Oncology Centre, Warszawa, , Poland

Medical Academy in Wrocław; Chair and Clinic of Haematology, Blood Neoplasm and Bone Marrow Transplantation, Wrocław, , Poland

SP ZOZ Silesian Centre of Cellular Transplantation, Wrocław, , Poland

Regional Oncology Centre, Ward of Proliferative Diseases, Łódź, , Poland

Contact Details

Name: Jan A Walewski, Prof.

Affiliation: Vice-president of PLRG

Role: PRINCIPAL_INVESTIGATOR

Name: Maria Podolak-Dawidziak, Prof.

Affiliation: PLRG Board Member

Role: STUDY_CHAIR

Name: Beata Stella-Hołowiecka, Assoc. Prof.

Affiliation: PLRG Member

Role: STUDY_CHAIR

Useful links and downloads for this trial

Clinicaltrials.gov

Google Search Results

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