Spots Global Cancer Trial Database for Predicting Biomarker of Gastric Cancer Chemotherapy Response
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Trial Identification
Brief Title: Predicting Biomarker of Gastric Cancer Chemotherapy Response
Official Title: Postgenome-based Systemic Discovery of Strong Biomarkers Predict Gastric Cancer Chemotherapy Response
Study ID: NCT03253107
Interventions
Study Description
Brief Summary: * discovery and validation of biomarker predicting gastric cancer chemotherapy response * Analysis for expression level of mRNA using Next generation sequencing in gastric cancer tissue by chemotherapy response * Analysis for expression level of miRNA using Next generation sequencing in gastric cancer tissue and blood by chemotherapy response * Validation of mRNA and miRNA using qRT-PCR in multiple independent cohort * Biological biomarkers-clinical factor combined prediction model of gastric cancer chemotherapy response
Detailed Description: * discovery and validation of biomarker predicting gastric cancer chemotherapy response * Analysis for expression level of mRNA in fresh frozen gastric cancer tissue by chemotherapy response (A) method of mRNA expression measurement: RNA sequencing (B) study group Palliative chemotherapy (inoperable patients) * institutional primary Chemotherapy regimen (XP or Xelox) 1. response group 2. progression group Post-OP adjuvant chemotherapy * institutional primary Chemotherapy regimen 1. complete response group 2. non-responder group <!-- --> 1. and 2) groups: age, sex, regimen matched * Analysis for expression level of miRNA using Next generation sequencing in gastric cancer tissue and blood by chemotherapy response (A) method of mRNA expression measurement: RNA sequencing (B) study group * the same patients in mRNA sequencing * Validation of mRNA and miRNA in multiple independent cohort method of measurement of RNA expression: qRT-PCR * Biological biomarkers-clinical factor combined prediction model of gastric cancer chemotherapy response combination of biologic biomarker and clinical factors to predict the chemotherapy response in gastric cancer
Eligibility
Minimum Age: 20 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
Kyungpook National University Medical Canter, Daegu, , Korea, Republic of
Contact Details
Name: Su Youn Nam, MD, PhD
Affiliation: Kyungpook National University Medical Center
Role: PRINCIPAL_INVESTIGATOR
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