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Spots Global Cancer Trial Database for A Study of Ripretinib vs Sunitinib in Advanced GIST Patients After Treatment With Imatinib

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We do not endorse or review these studies in any way.

Trial Identification

Brief Title: A Study of Ripretinib vs Sunitinib in Advanced GIST Patients After Treatment With Imatinib

Official Title: A Phase 3, Interventional, Randomized, Multicenter, Open-Label Study of Ripretinib vs Sunitinib in Patients With Advanced Gastrointestinal Stromal Tumor (GIST) After Treatment With Imatinib

Study ID: NCT03673501

Interventions

Ripretinib
Sunitinib

Study Description

Brief Summary: This is a 2-arm, randomized, open-label, international, multicenter study comparing the efficacy of ripretinib to sunitinib in GIST patients who progressed on or were intolerant to first-line anticancer treatment with imatinib. Approximately 426 patients will be randomized in a 1:1 ratio to ripretinib 150 mg once daily (continuous dosing for 6 week cycles) or sunitinib 50 mg once daily (6 week cycles, 4 weeks on, 2 weeks off).

Detailed Description:

Keywords

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: No

Locations

Mayo Clinic Scottsdale, Scottsdale, Arizona, United States

University of California San Diego Medical Center, La Jolla, California, United States

UCLA Hematology Oncology Center - Main Site, Los Angeles, California, United States

Stanford Medicine, Stanford, California, United States

University of Colorado Hospital - Anschutz Cancer Pavillion, Aurora, Colorado, United States

Rocky Mountain Cancer Centers, Denver, Colorado, United States

Smilow Cancer Hospital at Yale, New Haven, Connecticut, United States

Washington Cancer Institute at MedStar Washington Hospital Center, Washington, District of Columbia, United States

Mayo Clinic Florida, Jacksonville, Florida, United States

Sylvester Comprehensive Cancer Center, Miami, Florida, United States

Miami Cancer Institute at Baptist Health, Inc., Miami, Florida, United States

Orlando Health UF Health Cancer Center, Orlando, Florida, United States

Moffitt Cancer Center, Tampa, Florida, United States

Winship Cancer Institute, Atlanta, Georgia, United States

Georgia Cancer Specialists, Sandy Springs, Georgia, United States

Northwestern Memorial Hospital, Chicago, Illinois, United States

University of Chicago Medical Center, Chicago, Illinois, United States

IU Simon Cancer Center, Indianapolis, Indiana, United States

University of Iowa Hospital and Clinics, Iowa City, Iowa, United States

Norton Cancer Institute, Audubon Hospital Campus, Louisville, Kentucky, United States

Johns Hopkins Hospital, Baltimore, Maryland, United States

Dana Farber Cancer Institute, Boston, Massachusetts, United States

Henry Ford Health System, Detroit, Michigan, United States

University of Minnesota Medical Center-Fairview, Minneapolis, Minnesota, United States

Mayo Clinic, Rochester, Minnesota, United States

Washington University School of Medicine - Siteman Cancer Center, Saint Louis, Missouri, United States

Rutgers Cancer Institute, New Brunswick, New Jersey, United States

Montefiore Medical Center-Montefiore Medical Park, Bronx, New York, United States

Roswell Park Cancer Institute, Buffalo, New York, United States

The Monter Cancer Center, Lake Success, New York, United States

Memorial Sloan Kettering Cancer Center, New York, New York, United States

Duke University Medical Center, Durham, North Carolina, United States

The Ohio State University Comprehensive Cancer Center - Arthur G. James Cancer Hospital and Solove Research Institute, Columbus, Ohio, United States

University of Toledo, Toledo, Ohio, United States

Stephenson Cancer Center, Oklahoma City, Oklahoma, United States

Oregon Health & Science University Center for Health and Healing, Portland, Oregon, United States

Fox Chase Cancer Center, Philadelphia, Pennsylvania, United States

Henry-Joyce Cancer Clinic, Nashville, Tennessee, United States

Texas Oncology-Baylor Charles A. Sammons Cancer Center, Dallas, Texas, United States

University of Texas MD Anderson Cancer Center, Houston, Texas, United States

Virginia Commonwealth University Massey Cancer Center, Richmond, Virginia, United States

University of Washington Medical Center, Seattle, Washington, United States

Froedtert Hospital-Medical College of Wisconsin, Milwaukee, Wisconsin, United States

Sanatorio Allende, Córdoba, Cordoba, Argentina

Instituto Medicao Especializado Alexander Fleming, Buenos Aires, , Argentina

Border Medical Oncology Research Unit, Albury, New South Wales, Australia

Prince of Wales Hospital, Randwick, New South Wales, Australia

Princess Alexandra Hospital, Woolloongabba, Queensland, Australia

Ashford Cancer Centre Research, Kurralta Park, South Australia, Australia

Ashford Cancer Centre Research, Kurralta Park, South Australia, Australia

The Alfred Hospital, Melbourne, Victoria, Australia

Princess Alexandara Hospital, Woolloongabba, , Australia

Institut Jules Bordet, Bruxelles, , Belgium

UZ Leuven, Leuven, , Belgium

Cross Cancer Institute, Edmonton, Alberta, Canada

CancerCare Manitoba, Winnipeg, Manitoba, Canada

Juravinski Cancer Centre, Hamilton, Ontario, Canada

The Ottawa Hospital Cancer Centre, Ottawa, Ontario, Canada

Princess Margaret Cancer Centre, Toronto, Ontario, Canada

Hopital Maisonneuve-Rosemont, Québec, , Canada

Clinica San Carlos de Apoquindo Red Salud UC Christs, Santiago, , Chile

Fakultni nemocnice v Motole, Prague, , Czechia

Institut Bergonnié, Bordeaux, , France

Centre Georges François Leclerc, Dijon, , France

Centre Oscar Lambret, Lille Cedex, , France

Centre Léon Bérard, Lyon, , France

Hopital La Timone, Marseille, , France

IPC, Marseille, , France

IGR, Paris, , France

CHU Poitiers-Hopital la Miletrie, Poitiers, , France

ICO - Site René Gauducheau, Saint Herblain, , France

HELIOS Klinikum Berlin-Buch, Berlin, , Germany

Technische Universitat Dresden, Dresden, , Germany

West German Cancer Center, Essen, , Germany

Magyar Honvedseg Egeszsegugyi Kozpont, Budapest, , Hungary

Debreceni Egyetem, Debrecen, , Hungary

Shamir Medical Center (Assaf Harofeh), Be'er Ya'akov, , Israel

Rabin Medical Cente, Petah Tikva, , Israel

Tel-Aviv Sourasky Medical Center, Tel Aviv, , Israel

Azienda Ospedaliera Universitaria Policlinico Sant'Orsola Malpighi, Bologna, , Italy

stituto Scientifico Romagnolo Per Lo Studio e La Cura Dei Tumori, Meldola, , Italy

Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, , Italy

IOV - Istituto Oncologico Veneto IRCCS, Padova, , Italy

Universita degli Studi di Palermo, Palermo, , Italy

Università Campus Bio-Medico di Roma, Rome, , Italy

Asan Medical Center, Seoul, , Korea, Republic of

Samsung Medical Center, Seoul, , Korea, Republic of

Seoul National University Hospital, Seoul, , Korea, Republic of

Ajou University Hospital, Suwon, , Korea, Republic of

Antoni van Leeuwenhoek, Amsterdam, , Netherlands

The Netherlands Cancer Institute, Amsterdam, , Netherlands

University Medical Center Groningen, Groningen, , Netherlands

Leiden University Medical Centre, Leiden, , Netherlands

Oslo University Hospital, Oslo, , Norway

Centrum Onkologii-Instytut im. M. Sklodowskiej Curie, Warsaw, , Poland

National Cancer Centre, Singapore, , Singapore

Hospital de la Santa Creu i Sant Pau, Barcelona, , Spain

Hospital Universitari Vall d'Hebron, Barcelona, , Spain

Hospital de Basurto, Bilbao, , Spain

Hospital Universitario 12 de Octubre, Madrid, , Spain

Hospital Universitario Clinico San Carlos, Madrid, , Spain

Hospital Universitario HM Madrid Sanchinarro, Madrid, , Spain

Hospital Universitario La Paz, Madrid, , Spain

Hospital Universitario Ramon y Cajal, Madrid, , Spain

Hospital Clinico Universitario Virgen de la Victoria, Malaga, , Spain

Hospital Universitario Virgen del Rocio, Sevilla, , Spain

Instituto Valenciano de Oncología,, Valencia, , Spain

Complejo Hospitalario Universitario de Vigo, Vigo, , Spain

Karolinska universitetssjukhuset, Solna, , Sweden

Centre Hospitalier Universitaire Vaudois, Fondation du Centre Pluridisciplinaire d'Oncologi, Lausanne, , Switzerland

Universitaetsspital Zuerich, Klinik fuer Onkologie, Zurich, , Switzerland

Chang Gung Memorial Hospital, Linkou, Taoyuan County, Taiwan

Kaohsiung Chang Gung Memorial Hospital,, Kaohsiung, , Taiwan

China Medical University Hospital, Taichung, , Taiwan

National Chen Kung University Hospital, Tainan, , Taiwan

Taipei Veterans General Hospital, Taipei, , Taiwan

Beatson West of Scotland Cancer Centre, Glasgow, , United Kingdom

St James's University Hospital, Leeds, , United Kingdom

Royal Marsden Hospital - Fulham, London, , United Kingdom

University College London Hospitals, London, , United Kingdom

Weston Park Hospital, Sheffield, , United Kingdom

Contact Details

Useful links and downloads for this trial

Clinicaltrials.gov

Google Search Results

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