Spots Global Cancer Trial Database for Phase 3 Study of DCC-2618 vs Placebo in Advanced GIST Patients Who Have Been Treated With Prior Anticancer Therapies
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Trial Identification
Brief Title: Phase 3 Study of DCC-2618 vs Placebo in Advanced GIST Patients Who Have Been Treated With Prior Anticancer Therapies
Official Title: A Phase 3, INterVentional, Double-Blind, Placebo-Controlled Study to Assess the Safety and Efficacy of DCC-2618 In Patients With AdvanCed Gastrointestinal Stromal TUmorS Who Have Received Treatment With Prior Anticancer Therapies
Study ID: NCT03353753
Conditions
Study Description
Brief Summary: This is a 2-arm, randomized, placebo-controlled, double-blind, international, multicenter study comparing the efficacy of ripretinib (DCC-2618) to placebo in patients who have received treatment with prior anticancer therapies. Prior anticancer therapies must include imatinib, sunitinib, and regorafenib (3 prior therapies). Approximately 120 patients were randomized in a 2:1 ratio to ripretinib 150 mg QD or placebo
Detailed Description:
Keywords
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
HonorHealth, Scottsdale, Arizona, United States
University of Southern California - Norris, Los Angeles, California, United States
UCLA, Los Angeles, California, United States
Stanford, Stanford, California, United States
Mayo Clinic - Jacksonville, Jacksonville, Florida, United States
Georgia Cancer Specialists, Atlanta, Georgia, United States
University of Chicago, Chicago, Illinois, United States
Dana Farber Cancer Institute, Boston, Massachusetts, United States
University of Minnesota, Minneapolis, Minnesota, United States
Mayo Clinic, Rochester, Minnesota, United States
Columbia, New York, New York, United States
MSKCC, New York, New York, United States
Oregon Health & Science University, Portland, Oregon, United States
Fox Chase Cancer Center, Philadelphia, Pennsylvania, United States
MD Anderson Cancer Center, Houston, Texas, United States
Alfred University, Melbourne, , Australia
University Hospital Leuven, Leuven, , Belgium
Cross Cancer Center, Edmonton, Alberta, Canada
Princess Margaret Hospital, Toronto, , Canada
Helsinki University Central Hospital, Helsinki, , Finland
Institut Bergonié, Bordeaux, , France
Le Centre Léon Bérard, Lyon, , France
Gustave-Roussy, Villejuif, , France
Sarcoma Center Brandenburg, Brandenburg, , Germany
University Hospital Essen, Essen, , Germany
Universitätsmedizin Mannheim, Mannheim, , Germany
Istituto Nazionale dei Tumori, Milan, , Italy
Università Campus Bio-Medico di Roma, Rome, , Italy
Leiden University Medical Center, Leiden, , Netherlands
Maria Sklodowska-Curie Memorial Cancer Center, Warsaw, , Poland
NCC, Singapore, , Singapore
Vall d'Hebron, Barcelona, , Spain
Hospitalario Universitario Virgen del Rocío, Seville, , Spain
Royal Marsden, London, , United Kingdom
University of Sheffield, Sheffield, , United Kingdom
Contact Details
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