Spots Global Cancer Trial Database for Repurposed Drugs in Research for Cancer Clinical Trials- Pitavastatin
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Trial Identification
Brief Title: Repurposed Drugs in Research for Cancer Clinical Trials- Pitavastatin
Official Title: Phase 0 lead-in Trial of Pitavastatin in Primary and Recurrent Glioblastoma Patients
Study ID: NCT05977738
Interventions
Study Description
Brief Summary: The goal of this Phase 0 trial is to study if pre-operative oral pitavastatin administration reaches the tumour in patients with primary or a recurrent glioblastoma. The main question\[s\] it aims to answer are: * Does pitavastatin reach a cytotoxic concentration in gadolinium-enhanced tumour tissue after oral administration? * Does pitavastatin achieve a concentration that can synergize with temozolomide in the gadolinium non-enhanced area of the tumour? Participants will receive pitavastatin in differing dosages a week before their elective surgery and blood and tumour samples will be collected.
Detailed Description:
Keywords
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
Erasmus MC, Rotterdam, , Netherlands
Contact Details
Name: Clemens Dirven, MD, PhD
Affiliation: Erasmus Medical Center
Role: PRINCIPAL_INVESTIGATOR
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