Spots Global Cancer Trial Database for Grafts of GSCs Into Brain Organoids for Testing Anti-invasion Drugs
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Trial Identification
Brief Title: Grafts of GSCs Into Brain Organoids for Testing Anti-invasion Drugs
Official Title: Grafts of Patient-derived Glioblastoma Stem Cells Onto Autologous Brain Organoids. A Precision Medicine Model for Testing Drugs Against Tumor Invasion
Study ID: NCT05772741
Interventions
Study Description
Brief Summary: In patients operated for glioblastoma, glioma stem-like cell lines will be obtained from tumor tissue, and IPSCs from skin fibroblasts or PBMCs. Brain organoids will be generated from IPSCs and co-cultured with IPSCs to study brain invasion and ciliogenesis. 3D genome architecture of glioma stem-like cells will be investigated. Gene modulation and pharmacologic strategies to inhibit invasion and restore ciliogenesis will be explored.
Detailed Description:
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, , Italy
Contact Details
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