Spots Global Cancer Trial Database for PET/CT Imaging of Malignant Brain Tumors With 124I-NM404
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Trial Identification
Brief Title: PET/CT Imaging of Malignant Brain Tumors With 124I-NM404
Official Title: PET/CT Imaging of Malignant Brain Tumors With a Novel Radioiodinated Phospholipid Ether Analogue 124I-NM404
Study ID: NCT01516905
Interventions
Study Description
Brief Summary: The purpose of this study is to evaluate diagnostic imaging techniques using 124I-NM404 PET/CT in humans with brain metastases and GBMs. This goal will be accomplished by determining the optimal PET/CT protocol and comparing PET tumor uptake to MRI and calculating tumor dosimetry. A future aim of this study will be to compare non-invasive PET/CT and MRI findings with pathological specimens, which is the gold standard but is invasive and impractical in many cases, to determine the sensitivity and specificity of both techniques for accurately detecting tumor infiltration. The data obtained from this study will be used to develop larger diagnostic and therapeutic trials in brain tumors. The long-term goals of this research are to improve the diagnosis and treatment of malignant brain tumors by using radioiodinated NM404.
Detailed Description:
Keywords
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
University of Wisconsin Hospital and Clinics, Madison, Wisconsin, United States
Contact Details
Name: Lance Hall, MD
Affiliation: University of Wisconsin, Madison
Role: PRINCIPAL_INVESTIGATOR
Name: Scott Perlman, MD, MS
Affiliation: University of Wisconsin, Madison
Role: PRINCIPAL_INVESTIGATOR
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