Spots Global Cancer Trial Database for Modulation of Ciliogenesis in Glioma Stem Cells
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Trial Identification
Brief Title: Modulation of Ciliogenesis in Glioma Stem Cells
Official Title: Control of Growth and Invasiveness of Glioblastoma by Modulation of Ciliogenesis in Glioma Stem Cells. A Novel Target Against Glioblastoma for Precision Medicine. RF-2019-12368786
Study ID: NCT05772767
Study Description
Brief Summary: The study aims at investigating the cilium-related transcriptome in patients-derived glioblastoma stem cells and the potential impact of modulation of cilium players in vitro, in vivo and ex vivo in glioblastoma brain organoids. Moreover, drugs inhibiting cilia disassembly will be tested. Finally, the potential prognostic role of a cilium-related gene expression signature in glioblastoma will be assessed.
Detailed Description:
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, , Italy
Contact Details
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