Spots Global Cancer Trial Database for Bioavailability of Disulfiram and Metformin in Glioblastomas
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Trial Identification
Brief Title: Bioavailability of Disulfiram and Metformin in Glioblastomas
Official Title: Drug Level and Investigation of Novel Substances Indicated Downstream Effect in Glioblastoma
Study ID: NCT03151772
Conditions
Study Description
Brief Summary: Neuro-oncological trials may fail due to the drug never getting to the intended target (i.e. within the tumor micro environment). Also, changes' occurring in tumor cells when removed from patients and grown in-vitro is another limiting factor influencing the clinical success. Important questions are therefore: 1. Does the drug get there? 2. Does the drug do what it is intended to do? To improve chances of clinical success there is a need for rational and intelligent selection of potential drugs in future trials. This is an initiative for analyzing tumor concentration of preoperative administered repurposed drugs
Detailed Description:
Keywords
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
Sahlgrenska University Hospital, Göteborg, , Sweden
Contact Details
Name: Asgeir S Jakola, MD, PhD
Affiliation: Sahlgrenska University Hospital, Sweden
Role: PRINCIPAL_INVESTIGATOR
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