Spots Global Cancer Trial Database for metformin
Every month we try and update this database with for metformin cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.
The following info and data is provided "as is" to help patients around the globe.
We do not endorse or review these studies in any way.
| Study title | NCT ID | Conditions | Interventions | Eligibility | Organization | Link |
|---|---|---|---|---|---|---|
| Study to Evaluate the Effect of Metformin in the Prevention of HG in HR[+]/HER2[-] PIK3CA-mut Advanced BC Patients | NCT04300790 | Breast Cancer | Alpelisib Metformin Fulvestrant Letrozole Exemestane Vildagliptin Tamoxifen | 18 Years - | MedSIR | |
| Metformin to Prevent Late Miscarriage and Preterm Delivery in Women With Polycystic Ovary Syndrome | NCT01587378 | Pregnancy Polycystic Ovar... | Metformin placebo | 18 Years - 45 Years | Norwegian University of Science and Technology | |
| A Study of Metformin With or Without Rapamycin as Maintenance Therapy After Induction Chemotherapy in Subjects With Pancreatic Cancer | NCT02048384 | Metastatic Panc... | metformin alone... metformin (Arm ... rapamycin (Arm ... | 18 Years - | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | |
| Oxidative Phosphorylation Targeting In Malignant Glioma Using Metformin Plus Radiotherapy Temozolomide | NCT04945148 | Glioblastoma, I... | Metformin Radiation IMRT Temozolomide | 18 Years - | Hopital Foch | |
| Dose-finding Study of Metformin With Chemoradiation in Locally Advanced Head and Neck Squamous Cell Carcinoma | NCT02325401 | Head and Neck C... | Metformin Cisplatin Radiation Thera... | 18 Years - | University of Cincinnati | |
| Effect of Liraglutide in Obese Women With Polycystic Ovary Syndrome | NCT05965908 | Polycystic Ovar... | liraglutide Metformin | 20 Years - 40 Years | Beni-Suef University | |
| Effect of Dosage of Metformin on Menstruation and Lipid Profile in Women With Polycystic Ovary Syndrome | NCT01474967 | Polycystic Ovar... | Metformin Metformin | - | Hormozgan University of Medical Sciences | |
| Metformin for the Prevention of CRA Recurrence | NCT04885426 | Colorectal Aden... Metformin Chemoprevention | low-dose metfor... high-dose metfo... Placebo | 40 Years - 80 Years | Shanghai Jiao Tong University School of Medicine | |
| DA-EPOCH-Rituximab/Metformin (RM) for Double Hit Lymphoma | NCT02815397 | Diffuse Large B... | Metformin | 18 Years - | Rush University Medical Center | |
| Hypothalamic Obesity Following Craniopharyngioma Surgery: A Pilot Trial of Combined Metformin and Diazoxide Therapy | NCT00892073 | Hypothalamic Ob... | Diazoxide Metformin | 9 Years - 22 Years | The Hospital for Sick Children | |
| Combination Metformin and Oral Contraception for Polycystic Ovary Syndrome (PCOS) | NCT00682890 | Polycystic Ovar... PCOS Insulin Sensiti... | placebo metformin | 18 Years - 45 Years | Virginia Commonwealth University | |
| Effect of Laser Puncture Versus Ultraviolet Radiation on Women With Polycystic Ovarian Syndrome | NCT05986838 | Polycystic Ovar... | aser puncture ultraviolet rad... Metformin | 20 Years - 35 Years | Cairo University | |
| Phase II Lung Metcore - Preoperative Metformin for Lung Cancer | NCT03086733 | Non Small Cell ... Lung Cancer | Metformin | 18 Years - 90 Years | University Health Network, Toronto | |
| Rituximab, Cyclophosphamide, Vincristine and Prednisone (R-CHOP) Plus Metformin in Diffuse Large-B-cell Lymphoma | NCT03200015 | Diffuse Large B... | Metformin | 18 Years - | Hospital Universitario Dr. Jose E. Gonzalez | |
| Chemotherapy and Radiation Therapy With or Without Metformin Hydrochloride in Treating Patients With Stage III Non-small Cell Lung Cancer | NCT02186847 | Adenosquamous L... Bronchioloalveo... Large Cell Lung... Lung Adenocarci... Non-Small Cell ... Recurrent Non-S... Squamous Cell L... Stage IIIA Non-... Stage IIIB Non-... | Radiation Thera... Carboplatin Metformin Paclitaxel | 18 Years - | NRG Oncology | |
| Phase II Study of Oral Metformin for Intravesical Treatment of Non-muscle-invasive Bladder Cancer | NCT03379909 | Superficial Bla... Bladder Cancer | Metformin | 18 Years - | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | |
| Cortisol Regulation in Polycystic Ovary Syndrome (PCOS) | NCT00694759 | Polycystic Ovar... | pioglitazone metformin placebo | 18 Years - 45 Years | Oregon Health and Science University | |
| Treatment of Anovulatory Infertility in PCOS Patients | NCT00471523 | Infertility Polycystic Ovar... Anovulation | Clomiphene citr... Metformin | 18 Years - 41 Years | University Magna Graecia | |
| Endometrial Cancer Recurrence in Patients Taking Metformin | NCT05192850 | Recurrent Endom... | Metformin use | 18 Years - 99 Years | WellSpan Health | |
| Prostate Cancer Active Surveillance Metformin Trial | NCT01733836 | Prostate Cancer | Metformin placebo | 18 Years - 80 Years | University Health Network, Toronto | |
| Metformin for Prevention Gestational Diabetes in Pregnant Women With Polycystic Ovarian Syndrome | NCT02802215 | Polycystic Ovar... Diabetes, Gesta... | metformin placebo (folic ... | 20 Years - 40 Years | Ain Shams University | |
| Safety and Efficacy of Metronomic Cyclophosphamide, Metformin and Olaparib in Endometrial Cancer Patients | NCT02755844 | Recurrent Endom... | Olaparib metformin metronomic cycl... | 18 Years - 81 Years | Hospices Civils de Lyon | |
| Effect of Metformin on Decrement in Levothyroxin Dose Required for Thyroid Stimulating Hormone (TSH) Suppression in Patients With Differentiated Thyroid Cancer | NCT01341886 | Malignant Neopl... Malignant Neopl... | Metformin | - 80 Years | Mashhad University of Medical Sciences | |
| Malignancy Meta Analysis for BRL49653 | NCT01195259 | Diabetes Mellit... | allocation of t... | - | GlaxoSmithKline | |
| Metformin for Reduction of Paclitaxel-Related Neuropathy in Patients With Breast Cancer | NCT02360059 | Breast Cancer | Metformin Placebo Questionnaires Sensory and Fin... | 18 Years - 74 Years | M.D. Anderson Cancer Center | |
| Metformin and Omega-3 Fatty Acids in Woman With a History of Early Stage Breast Cancer | NCT02278965 | Stage 0 Breast ... Breast Neoplasm... Stage I Breast ... Stage II Breast... Stage III Breas... | Metformin Omega-3 fatty a... | 21 Years - 75 Years | Columbia University | |
| Adipokines in Obese Adolescents With Insulin Resistance | NCT01410604 | Obesity | Metformin Placebo | 9 Years - 18 Years | Hospital Regional de Alta Especialidad del Bajio | |
| Metformin With Neoadjuvant Chemoradiation to Improve Pathologic Responses in Rectal Cancer | NCT03053544 | Rectal Neoplasm... | Metformin | 19 Years - | Sunnybrook Health Sciences Centre | |
| Metformin in Infertile PCOS Patients | NCT00501904 | Polycystic Ovar... | Metformin | 18 Years - 35 Years | University Magna Graecia | |
| Survivorship Promotion In Reducing IGF-1 Trial | NCT02431676 | Breast Cancer Prostate Cancer Lung Cancer Colon Cancer Melanoma of Ski... Endometrial Can... Liver Cancer Pancreatic Canc... Rectal Cancer Kidney Cancer Other Solid Mal... | Metformin Coach Directed ... Self-control we... | 18 Years - | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | |
| A Phase II, Single-Arm Study of RAD001 (Everolimus), Letrozole, and Metformin in Patients With Advanced or Recurrent Endometrial Carcinoma | NCT01797523 | Endometrial Can... | Metformin Letrozole Everolimus | 18 Years - | M.D. Anderson Cancer Center | |
| Malignancy Meta Analysis for BRL49653 | NCT01195259 | Diabetes Mellit... | allocation of t... | - | GlaxoSmithKline | |
| Assessing Safety and Efficacy of Sintilimab and Metformin Combination Therapy in SCLC | NCT03994744 | Small-cell Lung... Small Cell Lung... Small Cell Lung... Small Cell Lung... | PD-1 inhibitor Metformin | 18 Years - 65 Years | Hunan Cancer Hospital | |
| Endometrial Effects of Metformin Action in Women With Polycystic Ovarian Syndrome (PCOS) | NCT01070160 | Polycystic Ovar... | Endometrin (pro... Metformin | 18 Years - 42 Years | Yale University | |
| Study of Management of Pasireotide-induced Hyperglycemia in Adult Patients With Cushing's Disease or Acromegaly | NCT02060383 | Cushing's Disea... Acromegaly | Pasireotide s.c... Sitagliptin Liraglutide Insulin Pasireotide LAR Metformin | 18 Years - | Novartis | |
| Study of Metformin With Carboplatin/Paclitaxel Chemotherapy in Patients With Advanced Ovarian Cancer | NCT02312661 | Epithelial Ovar... | Metformin Carboplatin Paclitaxel | 18 Years - | University Medical Center Groningen | |
| Effects of GLP-1 Analogue Combined With Metformin and Metformin on Gonadal and Metabolic Profiles in Chinese Overweight/Obese PCOS Patients With Hyperandrogenemia. | NCT04969627 | Polycystic Ovar... | Metformin Exenatide | 18 Years - 40 Years | Shengjing Hospital | |
| Metformin and Insulin to Pancreatic Cancer Related Diabetes (Type 3c) | NCT05306028 | Pancretic Cance... Diabete Mellitu... | Metformin or in... | 18 Years - 80 Years | Fudan University | |
| Effect of Metformin on Decrement in Levothyroxin Dose Required for Thyroid Stimulating Hormone (TSH) Suppression in Patients With Differentiated Thyroid Cancer | NCT01341886 | Malignant Neopl... Malignant Neopl... | Metformin | - 80 Years | Mashhad University of Medical Sciences | |
| Metformin vs Metformin Combined With GLP-1RA (Glucagon-like Peptide 1 Receptor Agonist) on Overweight/Obese PCOS Patients | NCT04029272 | Polycystic Ovar... | Metformin Exenatide 2 MG | 18 Years - 40 Years | Peking Union Medical College Hospital | |
| An Open-Labeled Pilot Study of Biomarker Response Following Short-Term Exposure to Metformin | NCT01816659 | Colorectal Carc... | Metformin ER | 18 Years - 75 Years | M.D. Anderson Cancer Center | |
| PCOS Treatment Using DLBS3233, Metformin, and Combination of Both | NCT01999686 | Polycystic Ovar... Insulin Resista... | DLBS3233 Metformin XR Placebo metform... Placebo DLBS323... | 18 Years - 40 Years | Dexa Medica Group | |
| Metformin in Stage IV Lung Adenocarcinoma | NCT01997775 | Non-small Cell ... | METFORMIN | 20 Years - 80 Years | National Cheng-Kung University Hospital | |
| Relative Desirability of Metformin vs. Birth Control Pill in Treating PCOS in Women of Later Reproductive Age | NCT03905941 | Polycystic Ovar... | Metformin Oral combined h... | 40 Years - 49 Years | University of Virginia | |
| An Open-Label Pilot Intervention Trial to Prevent Diabetes in Prediabetic Adult Survivors of Childhood Cancer | NCT04742751 | PreDiabetes Adult Children | Metformin Digital Interve... | 18 Years - 44 Years | St. Jude Children's Research Hospital | |
| Effect of Metformin on Breast Cancer Metabolism | NCT01266486 | Breast Cancer | Metformin | 18 Years - | Oxford University Hospitals NHS Trust | |
| A Pilot Study of Metformin in Patients With a Diagnosis of Li-Fraumeni Syndrome | NCT01981525 | Li-Fraumeni Syn... | Metformin | 18 Years - | National Institutes of Health Clinical Center (CC) | |
| Evaluation of Metformin Effect on the Fertility of Women Treated With 131I for Thyroid Cancer | NCT05468554 | Thyroid Cancer | metformin Radioactive iod... | 18 Years - 45 Years | Medical University of Bialystok | |
| Study of Biomarkers Associated With Fatigue in Patients With Early-Stage Breast Cancer Treated With Metformin or Placebo on NCIC-CTG-MA.32 | NCT01286233 | Breast Cancer Depression Fatigue Sleep Disorders | Metformin Placebo | 18 Years - 74 Years | NSABP Foundation Inc | |
| A Trial of Pembrolizumab and Metformin Versus Pembrolizumab Alone in Advanced Melanoma | NCT03311308 | Advanced Melano... | Pembrolizumab I... Metformin | 18 Years - | University of Pittsburgh | |
| The Effect of GLP-1 Agonists Versus OCs on Reproductive Disorders and Cardiovascular Risks in Overweight PCOS | NCT03151005 | Polycystic Ovar... Overweight Obesity | Metformin-GLP-1... Metformin-Oral ... | 18 Years - 50 Years | Xinqiao Hospital of Chongqing | |
| Exemestane-RAD001-Metformin | NCT01627067 | Breast Cancer | Everolimus Exemestane Metformin | 18 Years - | M.D. Anderson Cancer Center | |
| Combined Metformin and Clomiphene Citrate (CC) or Laparoscopic Ovarian Diathermy for Women With CC Resistant Polycystic Ovary Syndrome (PCOS) | NCT00969631 | Polycystic Ovar... | metformin HCl (... Laparoscopic ov... | 20 Years - 36 Years | Mansoura University | |
| Metformin and Simvastatin Use in Bladder Cancer | NCT02360618 | Bladder Cancer | Metformin Simvastatin | 18 Years - 85 Years | London Health Sciences Centre | |
| Study to Compare Between Combimed Metformin-letrozole and Ovarian Drilling in Pcos With Bilateral Ovarian Drilling in Clomiphene-resistant Infertile Women With Polycystic Ovarian Syndrome | NCT01693289 | Focus of Study | metformin plus ... ovarian drillin... | 18 Years - 35 Years | Zagazig University | |
| Vincristine, Dexamethasone, Doxorubicin, and PEG-asparaginase (VPLD) and Metformin for Relapsed Childhood Acute Lymphoblastic Leukemia (ALL) | NCT01324180 | Acute Lymphobla... | Metformin Vincristine Dexamethasone PEG-asparaginas... Doxorubicin Intrathecal che... | 1 Year - 30 Years | H. Lee Moffitt Cancer Center and Research Institute | |
| Metformin in High Responder Polycystic Ovary Syndrome (PCOS) Patients Undergoing IVF Cycles | NCT01233206 | Infertility Polycystic Ovar... | Metformin Placebo adminis... | 18 Years - 35 Years | University Magna Graecia | |
| Clinical Effects of Metformin on Fertility-sparing Treatment for Early Endometrial Cancer | NCT04792749 | Endometrial Can... | Metformin | 18 Years - 45 Years | Samsung Medical Center | |
| Effect of Metformin on Biomarkers of Colorectal Tumor Cell Growth | NCT01632020 | Colorectal Neop... | Placebo Metformin | 18 Years - | University of Arkansas | |
| Metformin vs Metformin Combined With GLP-1RA (Glucagon-like Peptide 1 Receptor Agonist) on Overweight/Obese PCOS Patients | NCT04029272 | Polycystic Ovar... | Metformin Exenatide 2 MG | 18 Years - 40 Years | Peking Union Medical College Hospital | |
| Calorie Restriction With or Without Metformin in Triple Negative Breast Cancer | NCT04248998 | Triple-negative... | Fasting-mimicki... Metformin Preoperative ch... | 18 Years - 75 Years | Fondazione IRCCS Istituto Nazionale dei Tumori, Milano | |
| Semaglutide vs Metformin in Polycystic Ovary Syndrome (PCOS) | NCT05646199 | Polycystic Ovar... | Metformin Semaglutide Inj... | 18 Years - 45 Years | University of Hull | |
| The Nephroprotective Effect of Metformin With Cisplatin in Bladder Cancer | NCT06215976 | Muscle-Invasive... | Metformin Hydro... | 18 Years - 65 Years | Cairo University | |
| Apoptotic Signaling Pathways in Rats With Endometrial Hyperplasia | NCT02872818 | Apoptotic Signa... | 17β estradiol h... Metformin medroxyprogeste... | 8 Weeks - 10 Weeks | Kayseri Education and Research Hospital | |
| The Effects of Neoadjuvant Metformin on Tumour Cell Proliferation and Tumour Progression in Pancreatic Ductal Adenocarcinoma | NCT02978547 | Resectable Panc... | Metformin Hydro... | 18 Years - | British Columbia Cancer Agency | |
| Celebrex and Metformin for Postoperative Hepatocellular Carcinoma | NCT03184493 | Liver Cancer | Celebrex plus M... Celebrex Metformin | 18 Years - 75 Years | Guangxi Medical University | |
| Metformin Hydrochloride as First-Line Therapy in Treating Patients With Locally Advanced or Metastatic Prostate Cancer | NCT01243385 | Prostate Cancer | Metformin | 18 Years - | Swiss Group for Clinical Cancer Research | |
| Simvastatin and Metformin Therapy in PCOS Women. Prospective Randomised Trial. | NCT00396513 | Polycystic Ovar... | Simvastatin Simvastatin and... Metformin | 18 Years - 40 Years | Poznan University of Medical Sciences | |
| A Randomized, 2x2 Factorial Design Biomarker Prevention Trial of Low-dose ASA and Metformin in Stage I-III Crc Patients | NCT03047837 | Tertiary Preven... | ASA MET Placebo | 18 Years - 80 Years | Ente Ospedaliero Ospedali Galliera | |
| Efficacy of Metformin in Lean Women With Polycystic Ovary Syndrome | NCT00319293 | Polycystic Ovar... | Metformin | 20 Years - 35 Years | Aarhus University Hospital Skejby | |
| Metformin for Reduction of Paclitaxel-Related Neuropathy in Patients With Breast Cancer | NCT02360059 | Breast Cancer | Metformin Placebo Questionnaires Sensory and Fin... | 18 Years - 74 Years | M.D. Anderson Cancer Center | |
| The Effect of Metformin on Breast Cancer Patients | NCT04559308 | Breast Cancer | Metformin Chemotherapy | 18 Years - 65 Years | Beni-Suef University | |
| Evaluation of Clinical Safety of Combining Metformin With Anticancer Chemotherapy | NCT01442870 | Cancer | Metformin | 18 Years - 79 Years | Tufts Medical Center | |
| SGLT2 Inhibitors in Patients With PCOS | NCT04700839 | Polycystic Ovar... | SGLT2 inhibitor... Metformin | 18 Years - 45 Years | Shanghai 10th People's Hospital | |
| Metformin Plus Sorafenib for Advanced HCC | NCT02672488 | Hepatocellular ... | Sorafenib Metformin | 18 Years - | Tianjin Medical University Cancer Institute and Hospital | |
| Clinical Activity of Metformin With High-dose of Dexamethasone in Relapse Multiple Myeloma | NCT02967276 | Multiple Myelom... | Metformin XR Dexamethasone | 18 Years - | University of Campinas, Brazil | |
| Efficacy of metfOrmin in PrevenTIng Glucocorticoid-induced Diabetes in Patients With Brain Metastases | NCT04001725 | Brain Metastase... Melanoma Lung Cancer Breast Cancer | Dexamethasone Metformin | 18 Years - 75 Years | Fondazione IRCCS Istituto Nazionale dei Tumori, Milano | |
| Metformin Use to Reduce Disparities in Newly Diagnosed Breast Cancer | NCT04741204 | Breast Cancer S... Insulin Resista... Racial Bias | Metformin Exten... | 18 Years - 80 Years | Woman's | |
| Pilot Study of Metformin in Head and Neck Squamous Cell Cancer and Its Effects on Stromal-epithelial Metabolic Uncoupling | NCT02083692 | Head and Neck S... | Metformin | 18 Years - 80 Years | Thomas Jefferson University | |
| Insulin Resistance and Metformin Use on Volume of Benign Thyroid Nodules | NCT03183752 | Thyroid Nodule Insulin Resista... | Metformin Placebo | 18 Years - 80 Years | Hospital Universitário Clementino Fraga Filho |
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