Spots Global Cancer Trial Database for An Integrated Radio-immunological Approach
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Trial Identification
Brief Title: An Integrated Radio-immunological Approach
Official Title: Identification of the Immuno Suppressive Characteristics of Glioma Patients by an Integrated Radio-immunological Approach
Study ID: NCT05267509
Conditions
Interventions
Study Description
Brief Summary: The most aggressive primary brain tumors in adults, glioblastomas, are characterized by a profound local and systemic immune suppression. During tumor progression, the infiltration of inflammatory leukocytes, especially of myeloid origin, endowed with immunosuppressive function is observed. Aim of this study is to evaluate myeloid cell infiltrate and iron metabolism in tumor-associated macrophages by combining a multimodal MRI imaging technique with immunophenotyping of the tumor microenvironment.
Detailed Description:
Keywords
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
University Hospital, Florence, , Italy
University Hospital, Padova, , Italy
Contact Details
Name: Susanna Mandruzzato, PhD
Affiliation: Istituto Oncologico Veneto IOV-IRCCS
Role: PRINCIPAL_INVESTIGATOR
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