Spots Global Cancer Trial Database for Radiogenomic and Prognosis Analysis in Glioma

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Trial Identification

Brief Title: Radiogenomic and Prognosis Analysis in Glioma

Official Title: Prospective Observational Study of Imaging-based Prediction for Genomic Mutations and Prognosis in Glioma

Study ID: NCT04122521

Conditions

Glioma

Interventions

MRI

Study Description

Brief Summary: This study aims to evaluate whether MRI can be used to predict genomics and prognosis in glioma. Given the profound prognostic significance of genetic mutations seen in glioma, there have been increasing attempts to correlate imaging characteristics with genetic, mutational and expression patterns. To be able to predict genomics and prognosis based on imaging alone will prove useful in patients with involvement of glioma in delicate areas of the brain and better reflect tumor and molecular heterogeneity.

Detailed Description: Previous studies have proposed certain imaging characteristics correlating with genetic, molecular and expression patterns. Advanced imaging provides additional clues but no studies have examined its added value particularly in a prospective setting. The investigator's aim to evaluate preoperative MRI for patients suspected of glioma to predict IDH mutation, 1p19q codeletion, MGMT methylation and EGFR mutation status using imaging characteristics such as margin, patterns of contrast enhancement and edema as well as diffusion and perfusion characteristics. This will be confirmed pathologically and further correlated with patients' long term outcome.