Spots Global Cancer Trial Database for Biomarker-based Algorithm for Diagnosis of Glioma
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Trial Identification
Brief Title: Biomarker-based Algorithm for Diagnosis of Glioma
Official Title: Development of a New Algorithm-based Classification for Glioma
Study ID: NCT04194593
Conditions
Interventions
Study Description
Brief Summary: ATRX (X-linked mental retardation and alpha-thalassaemia syndrome protein) loss and pTERT (Telomerase reverse transcriptase) mutation are diagnostic markers of gliomas. However, 4 to 28% of gliomas shows none of these alterations. The aim of this project is to propose a new test able to detect the telomeric status for every glioma. Based on this test and other markers (such as mutation of IDH1 (isocitrate dehydrogenase 1) and IDH2 (isocitrate dehydrogenase 2)), investigators propose an algorithm, able to classify the main subtypes of gliomas (astrocytoma, oligodendroglioma and glioblastoma).
Detailed Description:
Keywords
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
Institut de Pathologie Est, Biopathologie moléculaire, Hôpitaux Est, HCL, Bron, , France
Contact Details
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