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Spots Global Cancer Trial Database for Comparative Study of Intraoperative MRI-guided vs. Conventional Glioma Surgery

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Trial Identification

Brief Title: Comparative Study of Intraoperative MRI-guided vs. Conventional Glioma Surgery

Official Title: Resection Control of Primary Brain Tumours Using a Low-Field Intraoperative MRI

Study ID: NCT01394692

Conditions

Glioma

Study Description

Brief Summary: Excision to the maximum possible extent marks the first step of glioma surgery. Depending on tumour histology, adjuvant treatment consists of radio- and/or chemotherapy. Multi-centre studies have shown that the presence of residual tumour according to MRI-criteria is a prognostic factor in this incurable condition. In order to improve the extent of resection, several methods, in particular intraoperative imaging techniques, have become available to demonstrate already during surgery whether the goal of surgery has been achieved. The intraoperative MRI devices currently available differ in their magnetic field strengths and image resolution, but also in their amount of interference with the surgical workflow. Prospective, high-class evidence data to promote the use of intraoperative MRI in glioma surgery are lacking. To assess whether the rate of radiologically complete tumour resections can be improved by using intraoperative MRI-guidance, we designed this prospective, randomized trial. We hypothesized that the extent of resection that can be achieved using an intraoperative MRI is greater than that of conventional microsurgical tumor resection.

Detailed Description:

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: No

Locations

Department of Neurosurgery, Goethe-University, Frankfurt, , Germany

Contact Details

Name: Christian Senft, M.D.

Affiliation: Goethe University

Role: PRINCIPAL_INVESTIGATOR

Name: Volker Seifert, M.D.

Affiliation: Goethe University

Role: STUDY_DIRECTOR

Useful links and downloads for this trial

Clinicaltrials.gov

Google Search Results

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