Spots Global Cancer Trial Database for Evorpacept (ALX148) in Combination With Pembrolizumab in Patients With Advanced Head and Neck Squamous Cell Carcinoma (ASPEN-03)
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Trial Identification
Brief Title: Evorpacept (ALX148) in Combination With Pembrolizumab in Patients With Advanced Head and Neck Squamous Cell Carcinoma (ASPEN-03)
Official Title: A Phase 2 Study of ALX148 in Combination With Pembrolizumab in Patients With Advanced Head and Neck Squamous Cell Carcinoma (ASPEN-03)
Study ID: NCT04675294
Study Description
Brief Summary: A Phase 2 Study of evorpacept (ALX148) in Combination With pembrolizumab in Patients With Advanced Head and Neck Squamous Cell Carcinoma.
Detailed Description: This is a open-label, randomized phase 2 multi-center study of the anti-tumor efficacy of evorpacept (ALX148) + pembrolizumab and of pembrolizumab alone in patients with metastatic or unresectable, recurrent HNSCC that is PD-L1 positive (CPS ≥1 by an FDA-approved test) and who have not yet been treated for their advanced disease. The study comprises an initial safety lead-in cohort followed by a randomized portion.
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
Hoag Hospital, Irvine, California, United States
University of California San Diego, La Jolla, California, United States
H. Lee Moffitt Cancer Center, Tampa, Florida, United States
Northwest Georgia Oncology Centers, Marietta, Georgia, United States
Rush University Medical Center, Chicago, Illinois, United States
Blessing Cancer Center, Quincy, Illinois, United States
University of Maryland Medical System, Baltimore, Maryland, United States
University of Maryland, Baltimore, Maryland, United States
Massachusetts General Hospital, Boston, Massachusetts, United States
Rutgers Cancer Institute of New Jersey, Newark, New Jersey, United States
Memorial Sloan-Kettering Cancer Center, Long Island City, New York, United States
The Ohio State University, Columbus, Ohio, United States
Oregon Health & Science University, Portland, Oregon, United States
Vanderbilt - Ingram Cancer Center, Nashville, Tennessee, United States
Houston Methodist Cancer Center, Houston, Texas, United States
St. Vincent's, Sydney, New South Wales, Australia
Royal Brisbane and Womens Hospital, Brisbane, Queensland, Australia
Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia
Sir Charles Gairdner Hospital, Perth, Western Australia, Australia
Cliniques Universitaires Saint-Luc, Brussels, , Belgium
AZ Groeninge, Kortrijk, , Belgium
UZ Leuven, Leuven, , Belgium
Hamilton Health Sciences - Juravinski Cancer Centre, Hamilton, Ontario, Canada
LHSC - Victoria Hospital, London, Ontario, Canada
Ottawa Hospital Cancer Centre, Ottawa, Ontario, Canada
Princess Margaret Cancer Centre, Toronto, Ontario, Canada
Chungbuk National University Hospital, Cheongju, , Korea, Republic of
Yeungnam University Medical Center, Daegu, , Korea, Republic of
Chungnam National University Hospital, Daejeon, , Korea, Republic of
CHA University of Bundang, Gyeonggi-do, , Korea, Republic of
Gachon University - Gil Medical Center, Incheon, , Korea, Republic of
Seoul National University Bundang Hospital, Seongnam, , Korea, Republic of
Korea University Medical Center (KUMC) - Korea University Anam Hospital, Seoul, , Korea, Republic of
Seoul National University Hospital, Seoul, , Korea, Republic of
The Catholic University of Korea - Eunpyeong St. Mary's Hospital, Seoul, , Korea, Republic of
Samsung Medical Center, Seoul, , Korea, Republic of
SNU Boramae Medical Center, Seoul, , Korea, Republic of
Severance Hospital Yonsei University, Seoul, , Korea, Republic of
Catholic University of Korea, St. Vincent's Hospital Suwon, Suwon, , Korea, Republic of
Yonsei University - Wonju Severance Christian Hospital, Wŏnju, , Korea, Republic of
VUMC Goederenontvangst, Amsterdam, , Netherlands
Universitair Medisch Centrum Groningen, Groningen, , Netherlands
National University Cancer Institute, Singapore, , Singapore
National Cancer Centre Singapore, Singapore, , Singapore
Hospital Universitari Dexeus, Barcelona, , Spain
Institud Catala d´Oncologia, Barcelona, , Spain
Hospital Universitario La Paz, Madrid, , Spain
HM Sanchinarro, Madrid, , Spain
Hospital Severo Ochoa, Madrid, , Spain
Hospital Regional Universitario de Malaga, Málaga, , Spain
Hospital Universitario de Navarra, Pamplona, , Spain
Royal Marsden NHS Foundation Trust, London, , United Kingdom
Royal Marsden NHS Foundation Trust, Sutton, , United Kingdom
Contact Details
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