Spots Global Cancer Trial Database for DNA Analysis of Tissue Samples From Patients With Head and Neck Cancer

Study Description

Brief Summary: RATIONALE: Studying samples of tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. PURPOSE: This laboratory study is looking at DNA in tissue samples from patients with head and neck cancer.

Detailed Description: OBJECTIVES: * Assess common genetic mutations in tumor and germline DNA samples from patients with head and neck squamous cell carcinoma (HNSCC). * Search for viral DNAs and relate this information to demographics, tumor characteristics, and patient prognosis. * Search for novel viral sequences and cancer-associated gene mutations in young nonsmoking HNSCC patients and in other distinct head and neck cancers. * Determine tumor suppressor gene mutations in HNSCC patients and relate this information to gene expression data. * Validate gene expression information using independent techniques such as real-time PCR on expressed sequences and immunohistochemistry. OUTLINE: Genetic mutation analysis and gene expression studies are performed on tissue samples from patients with head and neck squamous cell carcinoma. Techniques used include real time-PCR and immunohistochemistry.

Keywords

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: No

Locations

Contact Details

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