Spots Global Cancer Trial Database for Study of Blood and Tissue Samples From Patients With Larynx Cancer, Pharynx Cancer, or Oral Cavity Cancer

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Trial Identification

Brief Title: Study of Blood and Tissue Samples From Patients With Larynx Cancer, Pharynx Cancer, or Oral Cavity Cancer

Official Title: Morphological and Molecular Characterization of Tumors of the Aero-digestive Tract in Patients Who Have no Risk Factors Such as Alcohol, Smoking, or Occupation

Study ID: NCT00963326

Conditions

Head and Neck Cancer

Interventions

laboratory biomarker analysis

Study Description

Brief Summary: RATIONALE: Studying samples of blood and tumor tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. PURPOSE: This research study is looking at blood and tissue samples from patients with larynx cancer, pharynx cancer, or oral cavity cancer.

Detailed Description: OBJECTIVES: Primary * Characterize, morphologically and molecularly, squamous cell carcinoma of the larynx, pharynx, or oral cavity in patients without high-risk factors, such as alcohol consumption, smoking, or occupation. Secondary * Study the impact parameters of morphology, molecular characteristics, and genomics on disease-free survival and overall survival of these patients. * Study the impact parameters of morphological, molecular, and genomic control in the tumor. * Assess, in advanced tumors, the risk of heterogeneity of morphological, molecular, and genomic control in the tumor. OUTLINE: This is a multicenter study. Blood, tumor tissue, and healthy tissue samples are collected before treatment begins. Patients are followed up every 3 months for 2 years (additional biopsies may be collected).