Spots Global Cancer Trial Database for Germline Mutations in Patients With Head and Neck Cancer and a Family History of Cancer
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Trial Identification
Brief Title: Germline Mutations in Patients With Head and Neck Cancer and a Family History of Cancer
Official Title: Familial HNSCC Syndrome and p16 Germline Mutations
Study ID: NCT00482872
Conditions
Study Description
Brief Summary: RATIONALE: Studying gene mutations in samples of DNA from patients with head and neck cancer and a family history of cancer may help doctors learn more about the development of cancer in families. PURPOSE: This clinical trial is studying germline mutations in patients with head and neck cancer and a family history of cancer.
Detailed Description: OBJECTIVES: * Measure the incidence of p16\^INK4a germline mutations in patients with squamous cell carcinoma of the head and neck and a family history of cancer. * Determine biologic activity of identified p16\^INK4a germline mutations. OUTLINE: DNA specimens are collected for genetic and mutation analysis and examined by PCR and flow cytometry. The activity of cells with p16 mutations is determined by cell cycle arrest functional assay.
Keywords
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
Vanderbilt-Ingram Cancer Center - Cool Springs, Nashville, Tennessee, United States
Vanderbilt-Ingram Cancer Center at Franklin, Nashville, Tennessee, United States
Vanderbilt-Ingram Cancer Center, Nashville, Tennessee, United States
Contact Details
Name: Wendell G. Yarbrough, MD, FACS
Affiliation: Vanderbilt-Ingram Cancer Center
Role: STUDY_CHAIR
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