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Spots Global Cancer Trial Database for Chemoradiotherapy With Elective Low Dose Nodal Radiation for Locally Advanced Head and Neck Cancer

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We do not endorse or review these studies in any way.

Trial Identification

Brief Title: Chemoradiotherapy With Elective Low Dose Nodal Radiation for Locally Advanced Head and Neck Cancer

Official Title: Chemoradiotherapy With Very Low Dose Elective Nodal IMRT for Locally Advanced Head & Neck Cancer: the CCRO11 Multi-Institutional Phase II Trial

Study ID: NCT01372111

Study Description

Brief Summary: Concurrent chemotherapy and radiation therapy (chemoRT) has become the standard of care for treatment of many patients with advanced head and neck squamous cell carcinoma (HNSCC), though many clinical questions remain. Prior experience has revealed locoregional control (LRC), disease free survival (DFS) and overall survival (OS) at 3 years exceeding 80% after treatment with the use of hyperfractionated intensity modulated radiation therapy (IMRT) and concurrent weekly cisplatin chemotherapy for patients with locally advanced HNSCC. This multi-institutional phase II ZCC00204 trial resulted in an acceptable quality of life (QOL) and toxicity profile. The current trial is an attempt to maintain high LRC, while further minimizing both acute and chronic toxicities, and maximizing QOL.

Detailed Description:

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: No

Locations

Coleman Radiation Oncology Center, Morehead City, North Carolina, United States

CarolinaEast Cancer Care, New Bern, North Carolina, United States

South Atlantic Radiation Oncology, Supply, North Carolina, United States

Coastal Carolina Radiation Oncology, Wilmington, North Carolina, United States

Zimmer Cancer Center, Wilmington, North Carolina, United States

Contact Details

Name: Patrick D. Maguire, M.D.

Affiliation: Coastal Carolina Radiation Oncology

Role: PRINCIPAL_INVESTIGATOR

Useful links and downloads for this trial

Clinicaltrials.gov

Google Search Results

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