Spots Global Cancer Trial Database for Protein Expression in Tumor Tissue Samples From Patients With Cancer of the Oropharynx

The following info and data is provided "as is" to help patients around the globe.
We do not endorse or review these studies in any way.

Trial Identification

Brief Title: Protein Expression in Tumor Tissue Samples From Patients With Cancer of the Oropharynx

Official Title: Protein Expression Profiles in Oropharyngeal Squamous Cell Carcinoma

Study ID: NCT00899340

Conditions

Head and Neck Cancer

Interventions

gene expression analysis

microarray analysis

protein expression analysis

immunohistochemistry staining method

laboratory biomarker analysis

Study Description

Brief Summary: RATIONALE: Studying the proteins expressed in samples of tumor tissue from patients with cancer may help doctors identify and learn more about biomarkers related to cancer. It may also help doctors plan better treatment for patients with cancer of the oropharynx. PURPOSE: This laboratory study is looking at protein expression in tumor tissue samples from patients with cancer of the oropharynx.

Detailed Description: OBJECTIVES: * To investigate if some of the differences in gene expression are also reflected at the protein level. * To determine whether differences in gene expression that are also reflected at the protein level can be used to develop markers for early detection and disease surveillance. * To identify targets for therapy. OUTLINE: Archived tumor tissue samples are analyzed for expression of standard immunohistological markers (e.g., p16, p53, and Ki-67) as well as expression of genes identified in a previous gene expression study. Protein expression data are tested for clinical and demographic correlates and compared with gene expression data.