Spots Global Cancer Trial Database for Optical Coherence Tomography in Patients With Radiotherapy for Head and Neck Cancer

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Trial Identification

Brief Title: Optical Coherence Tomography in Patients With Radiotherapy for Head and Neck Cancer

Official Title: Live Laser Microscopic Evaluation (OCT) of Radiation Induced Preclinical Alterations of the Skin in Head and Neck Cancer Patients

Study ID: NCT04610645

Conditions

Head and Neck Cancer

Radiotherapy

Interventions

OCT

Dermatoscope

3-Colour FISH

Study Description

Brief Summary: The purpose of this study is to determine whether any eventual skin damage caused by radiation therapy can be detected and monitored at a subclinical level via optical coherence tomography (OCT). Another key question is whether subclinical OCT detected skin damage correlates with acute and late clinical toxicity.

Detailed Description: Head and neck cancer patients that meet the eligibility criteria and singned the informed consent will undergo OCT-measurements before, during and after the course of radiation therapy. At the same time-points the skin areas are evaluated with dermatoscopy and patients are asked to self-assess their quality of life (EORTC QLQ C30 and respective head and neck module H\&N 43). Before the onset of radiation therapy radiation sensitivity analysis will be performed with in-vitro irradion of peripheral blood lymphocytes (FISH).