Spots Global Cancer Trial Database for Genetic Analysis in Diagnosing Thyroid Cancer in Patients With Thyroid Nodules

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Trial Identification

Brief Title: Genetic Analysis in Diagnosing Thyroid Cancer in Patients With Thyroid Nodules

Official Title: Gene Expression Analysis in Thyroid Nodule FNA Samples

Study ID: NCT00316823

Conditions

Head and Neck Cancer

Interventions

gene expression analysis

polymerase chain reaction

reverse transcriptase-polymerase chain reaction

diagnostic laboratory biomarker analysis

immunohistochemistry staining method

needle biopsy

Study Description

Brief Summary: RATIONALE: Finding genetic markers for thyroid cancer in a biopsy specimen may help doctors diagnose thyroid cancer. PURPOSE: This clinical trial is studying how well genetic analysis works in diagnosing thyroid cancer in patients with thyroid nodules.

Detailed Description: OBJECTIVES: * Evaluate the diagnostic accuracy of biomarkers and mRNA expression analysis using fine-needle aspiration (FNA) biopsy samples from patients with thyroid nodules. * Correlate the level of gene expression with the aggressiveness of differentiated thyroid cancer in FNA biopsy samples. OUTLINE: Patients undergo fine-needle aspiration (FNA) biopsy as part of routine care. Additional thyroid tissue is collected during the biopsy for gene expression analysis. Patients who have already had a biopsy undergo FNA biopsy during thyroidectomy. Tissue samples will be examined for gene expression by reverse transcriptase-polymerase chain reaction (PCR), real-time quantitative PCR, and immunohistochemistry. PROJECTED ACCRUAL: A total of 400 patients will be accrued for this study.