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Brief Title: Gemcitabine in Treating Patients With Advanced Salivary Gland Cancer That Cannot Be Removed During Surgery
Official Title: Gemcitabine for Advanced Salivary Cancer: A Phase II Study
Study ID: NCT00003744
Brief Summary: The purpose of this study is to see how patients with incurable salivary gland cancer, who have not had chemotherapy before, respond to Gemcitabine. The investigators are trying to find out what effects (good and bad) Gemcitabine has on participants and salivary gland cancer. Gemcitabine has been shown to be an effective chemotherapy agent in other types of cancer, including; bladder cancer, breast cancer, certain types of lung cancer, ovarian cancer, and pancreas cancer. Gemcitabine has yet to be studied for efficacy in subjects with salivary gland cancer and in general other chemotherapy drugs have shown to be ineffective so far in this population.
Detailed Description: OBJECTIVES: * Evaluate the response rate of patients with incurable salivary gland cancer treated with gemcitabine. * Evaluate the time to progression and toxicity of this therapy in these patients. OUTLINE: This is a multicenter study. Patients receive gemcitabine IV for 30 minutes on days 1, 8, and 15 of each 28 day course. Patients receive a minimum of 2 courses of treatment. Patients may continue treatment in the absence of disease progression or unacceptable toxicity. Patients are followed every 2 months. .
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
University of Chicago Cancer Research Center, Chicago, Illinois, United States
Massachusetts General Hospital, Boston, Massachusetts, United States
Dana Farber Cancer Institute, Boston, Massachusetts, United States
Harvard Pilgrim Health Care Institute, Boston, Massachusetts, United States
Lahey Clinic, Burlington, Massachusetts, United States
Sarah Cannon Research Institute, Nashville, Tennessee, United States
Name: Marshall R. Posner, MD
Affiliation:
Role: STUDY_CHAIR