Spots Global Cancer Trial Database for Value of FLT-PET Before and During Radiotherapy in Head and Neck Tumors
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Trial Identification
Brief Title: Value of FLT-PET Before and During Radiotherapy in Head and Neck Tumors
Official Title: Value of FLT-PET Before and During Radiotherapy in Head and Neck Tumors
Study ID: NCT00163176
Conditions
Interventions
Study Description
Brief Summary: Tumor cell proliferation and repopulation contribute to resistance to radiotherapy in head and neck cancer. Up to now, this characteristic is mostly assessed using biopsies acquired during inspection under general anaesthesia before treatment. 18F-FLT-PET (positron emission tomography) is a non-invasive imaging method showing areas of active proliferation. The aim of this study is to assess the value of the functional information gained by 18F-FLT-PET for radiotherapy planning and early tumor response assessment. Prior to radiotherapy, a planning CT-scan and a 18F-FLT-PET scan are acquired. After approximately two weeks of radiotherapy a further PET scan is obtained.
Detailed Description:
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
Radboud University Nijmegen, Department of Radiotherapy, Nijmegen, Gelderland, Netherlands
Contact Details
Name: Johannes HA Kaanders, PhD
Affiliation: Radboud University Medical Center
Role: PRINCIPAL_INVESTIGATOR
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