Spots Global Cancer Trial Database for Study of Monalizumab and Cetuximab in Patients With Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck
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Trial Identification
Brief Title: Study of Monalizumab and Cetuximab in Patients With Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck
Official Title: Phase 1b/2 Trial of IPH2201 And Cetuximab in Patients With Human Papillomavirus (HPV) (+) and HPV (-) Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck
Study ID: NCT02643550
Conditions
Study Description
Brief Summary: The objective of this study is to evaluate in a 3 +3 design, the safety of escalating doses of Monalizumab given IV in combination with cetuximab in patients who have received prior systemic regimen(s) for recurrent and/or metastatic squamous cell carcinoma of the head and neck (SCCHN). Cohorts expansion will evaluate antitumor activity of monalizumab and cetuximab with or without anti-PD(L)1
Detailed Description:
Keywords
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
University of California, Moores Cancer Center, La Jolla, California, United States
Stanford Cancer Center, Stanford, California, United States
University of Chicago, Chicago, Illinois, United States
University of Maryland, Greenebaum Comprehensive Cancer Center, Baltimore, Maryland, United States
Washington University School of Medicine, Saint Louis, Missouri, United States
Icahn School of Medicine at Mount Sinaï, New York, New York, United States
University of Pennsylvania, Philadelphia, Pennsylvania, United States
Fox Chase Cancer Center, Philadelphia, Pennsylvania, United States
Vanderbilt University Medical Center, Nashville, Tennessee, United States
Centre Jean Perrin, Clermont-Ferrand, , France
Centre Oscar Lambret, Lille, , France
Centre Leon Berard, Lyon, , France
Hopital La Timone, Marseille, , France
Institut Regional du Cancer de Montpellier, Montpellier, , France
Centre Antoine Lacassagne, Nice, , France
Centre Eugene Marquis, Rennes, , France
ICO Rene Gauducheau, Saint-Herblain, , France
Institut Gustave Roussy, Villejuif, , France
Contact Details
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