Spots Global Cancer Trial Database for Tissue Microarray of Hematological Malignancies
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Trial Identification
Brief Title: Tissue Microarray of Hematological Malignancies
Official Title: Tissue Microarray of Hematological Malignancies: Search for Novel Regulators of Disease Pathology Across Disease Entities
Study ID: NCT04142372
Conditions
Interventions
Study Description
Brief Summary: The aim of the study is to create new tools for improving management of patients with hematological malignancies by combining extensive clinical data from patients newly diagnosed with hematological malignancies and innovative laboratory analyses made on available tissue samples in regional biobanks from these patients.
Detailed Description: Firstly, clinical information is collected on all hematological malignancies diagnosed in our hospital district area retrospectively between the years 2000 and 2019. Clinical outcomes, laboratory results, clinically relevant diagnoses, characteristics defining clinical stage and established prognostic parameters are gathered. Simultaneously a tissue microarray (TMA) of diagnostic samples is compiled using representative annotated tissue areas. This TMA is used in combination with additional control material to identify prognostic and predictive biomarkers. A combined microarray dataset of hematological malignancies (Hemap) is utilized to point out genes of possible drug targets, disease specific markers, prognostic markers, or predictive markers. The clinical datasets and Hemap dataset is ultimately utilized to gain knowledge, new tools for prognostication and diagnostics, and targets for treatment. Artificial intelligence -assisted differential diagnostics will be tested.
Eligibility
Minimum Age:
Eligible Ages: CHILD, ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
Tampere Univerisity Hospital, Tampere, , Finland
Contact Details
Name: Artturi Mäkinen, MD
Affiliation: Tampere University
Role: PRINCIPAL_INVESTIGATOR
Name: Olli Lohi, MD, PhD
Affiliation: Tampere University
Role: STUDY_CHAIR
Name: Merja Heinäniemi, PhD
Affiliation: University of Eastern Finland
Role: STUDY_CHAIR
Name: Matti Vänskä, MD, PhD
Affiliation: Tampere University Hospital
Role: PRINCIPAL_INVESTIGATOR
Name: Tiina Lyly-Yrjänäinen, MD, PhD
Affiliation: Tampere University Hospital
Role: PRINCIPAL_INVESTIGATOR
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