Spots Global Cancer Trial Database for Efficacy and Tolerability of ABT-869 Versus Sorafenib in Advanced Hepatocellular Carcinoma (HCC)
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Trial Identification
Brief Title: Efficacy and Tolerability of ABT-869 Versus Sorafenib in Advanced Hepatocellular Carcinoma (HCC)
Official Title: An Open-label, Randomized Phase 3 Study of the Efficacy and Tolerability of Linifanib (ABT-869) Versus Sorafenib in Subjects With Advanced Hepatocellular Carcinoma (HCC)
Study ID: NCT01009593
Conditions
Study Description
Brief Summary: The primary objective of this study is to assess the overall survival (OS) of oral linifanib given as monotherapy once daily (QD) compared to sorafenib given twice daily (BID) per standard of care in subjects with advanced or metastatic HCC.
Detailed Description: The IDMC recommended discontinuation of the study, and, the protocol was amended to end study treatment.
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
Site Reference ID/Investigator# 23247, Beverly Hills, California, United States
Site Reference ID/Investigator# 23608, LaVerne, California, United States
Site Reference ID/Investigator# 23852, Orange, California, United States
Site Reference ID/Investigator# 40162, Orange, California, United States
Site Reference ID/Investigator# 23254, Newark, Delaware, United States
Site Reference ID/Investigator# 23253, Gainesville, Georgia, United States
Site Reference ID/Investigator# 23609, Honolulu, Hawaii, United States
Site Reference ID/Investigator# 24848, Honolulu, Hawaii, United States
Site Reference ID/Investigator# 23250, Louisville, Kentucky, United States
Site Reference ID/Investigator# 23257, St. Louis, Missouri, United States
Site Reference ID/Investigator# 23603, Las Vegas, Nevada, United States
Site Reference ID/Investigator# 23244, Durham, North Carolina, United States
Site Reference ID/Investigator# 23252, Portland, Oregon, United States
Site Reference ID/Investigator# 35705, Buenos Aires, , Argentina
Site Reference ID/Investigator# 35702, Rosario, Santa Fe, , Argentina
Site Reference ID/Investigator# 23152, Camperdown, , Australia
Site Reference ID/Investigator# 23150, Concord, , Australia
Site Reference ID/Investigator# 27122, Kingswood, , Australia
Site Reference ID/Investigator# 23153, Kogarah, , Australia
Site Reference ID/Investigator# 24103, Southport, , Australia
Site Reference ID/Investigator# 27968, Graz, , Austria
Site Reference ID/Investigator# 27969, Innsbruck, , Austria
Site Reference ID/Investigator# 27970, Linz, , Austria
Site Reference ID/Investigator# 27967, Vienna, , Austria
Site Reference ID/Investigator# 38902, Brussels, , Belgium
Site Reference ID/Investigator# 23162, Brussels, , Belgium
Site Reference ID/Investigator# 23843, Edegem, , Belgium
Site Reference ID/Investigator# 23161, Ghent, , Belgium
Site Reference ID/Investigator# 23842, Gilly, , Belgium
Site Reference ID/Investigator# 23163, Leuven, , Belgium
Site Reference ID/Investigator# 26702, Edmonton, , Canada
Site Reference ID/Investigator# 25482, Halifax, , Canada
Site Reference ID/Investigator# 39614, Montreal, , Canada
Site Reference ID/Investigator# 23184, Ottawa, , Canada
Site Reference ID/Investigator# 23183, Sherbrooke, , Canada
Site Reference ID/Investigator# 24522, Toronto, , Canada
Site Reference ID/Investigator# 36967, Temuco, , Chile
Site Reference ID/Investigator# 36964, Vina del Mar, , Chile
Site Reference ID/Investigator# 23186, Beijing, , China
Site Reference ID/Investigator# 43443, Changchun, , China
Site Reference ID/Investigator# 23194, Chengdu, , China
Site Reference ID/Investigator# 43442, Chongqing, , China
Site Reference ID/Investigator# 44444, Dalian, , China
Site Reference ID/Investigator# 43444, Fuzhou, , China
Site Reference ID/Investigator# 43482, Guangzhou City, , China
Site Reference ID/Investigator# 42563, Hangzhou, , China
Site Reference ID/Investigator# 44443, Harbin, , China
Site Reference ID/Investigator# 44062, Jinan, , China
Site Reference ID/Investigator# 23191, Nanjing City, , China
Site Reference ID/Investigator# 44063, Nanning City, , China
Site Reference ID/Investigator# 42817, Qingdao, , China
Site Reference ID/Investigator# 40624, Shanghai, , China
Site Reference ID/Investigator# 23189, Shanghai, , China
Site Reference ID/Investigator# 40448, Suzhou, , China
Site Reference ID/Investigator# 23190, Xian, , China
Site Reference ID/Investigator# 23167, Brno, , Czech Republic
Site Reference ID/Investigator# 23166, Olomouc, , Czech Republic
Site Reference ID/Investigator# 24523, Prague 2, , Czech Republic
Site Reference ID/Investigator# 23844, Prague 4, , Czech Republic
Site Reference ID/Investigator# 40930, Prague 8, , Czech Republic
Site Reference ID/Investigator# 23197, Usti nad Labem, , Czech Republic
Site Reference ID/Investigator# 23442, Aarhus C, , Denmark
Site Reference ID/Investigator# 23198, Alexandria, , Egypt
Site Reference ID/Investigator# 23199, Cairo, , Egypt
Site Reference ID/Investigator# 43302, Amiens, , France
Site Reference ID/Investigator# 23201, Clichy, , France
Site Reference ID/Investigator# 43144, Creteil, , France
Site Reference ID/Investigator# 23200, Lille Cedex, , France
Site Reference ID/Investigator# 23168, Paris Cedex 12, , France
Site Reference ID/Investigator# 40623, Paris Cedex 13, , France
Site Reference ID/Investigator# 28345, Rouen Cedex, , France
Site Reference ID/Investigator# 23165, Strasbourg Cedex, , France
Site Reference ID/Investigator# 28347, Vandoeuvre Les Nancy, , France
Site Reference ID/Investigator# 23267, Berlin, , Germany
Site Reference ID/Investigator# 23845, Bochum, , Germany
Site Reference ID/Investigator# 23266, Frankfurt am Main, , Germany
Site Reference ID/Investigator# 23268, Freiburg, , Germany
Site Reference ID/Investigator# 23269, Mainz, , Germany
Site Reference ID/Investigator# 24525, Athens, , Greece
Site Reference ID/Investigator# 24980, Hong Kong, , Hong Kong
Site Reference ID/Investigator# 27998, Benevento, , Italy
Site Reference ID/Investigator# 23424, Milan, , Italy
Site Reference ID/Investigator# 41488, Milan, , Italy
Site Reference ID/Investigator# 23425, Palermo, , Italy
Site Reference ID/Investigator# 41542, Pavia, , Italy
Site Reference ID/Investigator# 23428, Rome, , Italy
Site Reference ID/Investigator# 24042, Rome, , Italy
Site Reference ID/Investigator# 26506, Aichi, , Japan
Site Reference ID/Investigator# 36308, Chiba, , Japan
Site Reference ID/Investigator# 37602, Chiba, , Japan
Site Reference ID/Investigator# 29758, Fukuoka, , Japan
Site Reference ID/Investigator# 37603, Hokkaido, , Japan
Site Reference ID/Investigator# 28189, Ibaraki-ken, , Japan
Site Reference ID/Investigator# 26505, Kanazawa, , Japan
Site Reference ID/Investigator# 29757, Kumamoto, , Japan
Site Reference ID/Investigator# 27343, Kurume, , Japan
Site Reference ID/Investigator# 29759, Matsuyama-city, , Japan
Site Reference ID/Investigator# 26508, Osakasayama, , Japan
Site Reference ID/Investigator# 26507, Osaka, , Japan
Site Reference ID/Investigator# 27959, Osaka, , Japan
Site Reference ID/Investigator# 29756, Shimotsuke, , Japan
Site Reference ID/Investigator# 36782, Shizuoka, , Japan
Site Reference ID/Investigator# 28187, Tochigi-ken, , Japan
Site Reference ID/Investigator# 26503, Tokyo, , Japan
Site Reference ID/Investigator# 27242, Tokyo, , Japan
Site Reference ID/Investigator# 26504, Yokohama City, , Japan
Site Reference ID/Investigator# 26509, Yufu, , Japan
Site Reference ID/Investigator# 23447, Busan, , Korea, Republic of
Site Reference ID/Investigator# 39003, Busan, , Korea, Republic of
Site Reference ID/Investigator# 23445, Busan, , Korea, Republic of
Site Reference ID/Investigator# 23444, Daegu, , Korea, Republic of
Site Reference ID/Investigator# 26543, Gyeonggi-do, , Korea, Republic of
Site Reference ID/Investigator# 23457, Jeollanam-do, , Korea, Republic of
Site Reference ID/Investigator# 39002, Jeonju-si, , Korea, Republic of
Site Reference ID/Investigator# 23454, Seoul, , Korea, Republic of
Site Reference ID/Investigator# 25562, Seoul, , Korea, Republic of
Site Reference ID/Investigator# 23449, Seoul, , Korea, Republic of
Site Reference ID/Investigator# 23456, Seoul, , Korea, Republic of
Site Reference ID/Investigator# 23450, Suwon-si, , Korea, Republic of
Site Reference ID/Investigator# 23460, Kuala Lumpur, , Malaysia
Site Reference ID/Investigator# 23461, Penang, , Malaysia
Site Reference ID/Investigator# 23459, Petaling Jaya, Selangor, , Malaysia
Site Reference ID/Investigator# 23155, Durango, DGO., , Mexico
Site Reference ID/Investigator# 43102, Monterrey, NL, , Mexico
Site Reference ID/Investigator# 43145, Monterrey, NL, , Mexico
Site Reference ID/Investigator# 23272, Amsterdam, , Netherlands
Site Reference ID/Investigator# 23270, Amsterdam, , Netherlands
Site Reference ID/Investigator# 24782, Rotterdam, , Netherlands
Site Reference ID/Investigator# 23160, Auckland, , New Zealand
Site Reference ID/Investigator# 23846, Oslo, , Norway
Site Reference ID/Investigator# 42706, Ponce, , Puerto Rico
Site Reference ID/Investigator# 42705, San Juan, , Puerto Rico
Site Reference ID/Investigator# 33979, Baia Mare, , Romania
Site Reference ID/Investigator# 33344, Bucharest, , Romania
Site Reference ID/Investigator# 33343, Cluj Napoca, , Romania
Site Reference ID/Investigator# 33977, Craiova, , Romania
Site Reference ID/Investigator# 33345, Iasi, , Romania
Site Reference ID/Investigator# 33346, Oradea, , Romania
Site Reference ID/Investigator# 43202, Chelyabinsk, , Russian Federation
Site Reference ID/Investigator# 43203, Kazan, , Russian Federation
Site Reference ID/Investigator# 23462, Moscow, , Russian Federation
Site Reference ID/Investigator# 23849, Moscow, , Russian Federation
Site Reference ID/Investigator# 23159, Singapore, , Singapore
Site Reference ID/Investigator# 23158, Singapore, , Singapore
Site Reference ID/Investigator# 23466, A Coruna, , Spain
Site Reference ID/Investigator# 26063, Madrid, , Spain
Site Reference ID/Investigator# 40931, Madrid, , Spain
Site Reference ID/Investigator# 23465, Madrid, , Spain
Site Reference ID/Investigator# 23463, Madrid, , Spain
Site Reference ID/Investigator# 23467, Santander, , Spain
Site Reference ID/Investigator# 23468, Zaragoza, , Spain
Site Reference ID/Investigator# 23475, Changhua City, , Taiwan
Site Reference ID/Investigator# 23472, Kaohsiung County, , Taiwan
Site Reference ID/Investigator# 25262, Taichung City, , Taiwan
Site Reference ID/Investigator# 23474, Taichung, , Taiwan
Site Reference ID/Investigator# 23476, Tainan, , Taiwan
Site Reference ID/Investigator# 23478, Tainan, , Taiwan
Site Reference ID/Investigator# 23477, Tainan, , Taiwan
Site Reference ID/Investigator# 23470, Taipei City, , Taiwan
Site Reference ID/Investigator# 43237, Taipei, , Taiwan
Site Reference ID/Investigator# 23473, Taipei, , Taiwan
Site Reference ID/Investigator# 23469, Taipei, , Taiwan
Site Reference ID/Investigator# 23471, Taoyuan, , Taiwan
Contact Details
Name: Justin Ricker, MD
Affiliation: Abbott
Role: STUDY_DIRECTOR
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