Spots Global Cancer Trial Database for Effect of Vascular Inflow Occlusion in Open Liver Resection for Hepatocellular Carcinoma
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Trial Identification
Brief Title: Effect of Vascular Inflow Occlusion in Open Liver Resection for Hepatocellular Carcinoma
Official Title: Open Liver Resection With or Without Vascular Inflow Occlusion for Hepatocellular Carcinoma: a Randomized Controlled Trial
Study ID: NCT01759901
Conditions
Interventions
Study Description
Brief Summary: Bleeding is a major problem during liver resection. Vascular inflow occlusion, also known as Pringle maneuver, has been commonly employed to reduce blood loss during liver surgery. However, Pringle maneuver might cause ischaemic insult to the remnant liver and lead to post-operative liver dysfunction. The investigators hypothesize that liver resection without the use of vascular inflow occlusion (Pringle maneuver) is associated with lower postoperative complications rate. The aim of this study is to evaluate whether elective open liver resection without vascular inflow occlusion (Pringle Maneuvre) would lead to a reduction of post-operative surgical complications in patient with hepatocellular carcinoma. Eligible patients undergoing liver resection in the Prince of Wales Hospital will be recruited and randomized into 2 study arms comparing the effect of Pringle maneuver.
Detailed Description:
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
The Prince of Wales Hospital, Hong Kong, , China
Contact Details
Name: Kit Fai Lee, MBBS
Affiliation: Clinical Associate Professor (honorary)
Role: PRINCIPAL_INVESTIGATOR
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