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Intermittent vascular inflow occlusion applied during liver resection

No vascular inflow occlusion applied during liver resection

Vascular clamp is applied across hepatoduodenal ligament intermittently in 15 minutes on / 5 minutes off interval

Pringle

Kit Fai Lee, MBBS

Bleeding is a major problem during liver resection. Vascular inflow occlusion, also known as Pringle maneuver, has been commonly employed to reduce blood loss during liver surgery. However, Pringle maneuver might cause ischaemic insult to the remnant liver and lead to post-operative liver dysfunction.

The investigators hypothesize that liver resection without the use of vascular inflow occlusion (Pringle maneuver) is associated with lower postoperative complications rate.

The aim of this study is to evaluate whether elective open liver resection without vascular inflow occlusion (Pringle Maneuvre) would lead to a reduction of post-operative surgical complications in patient with hepatocellular carcinoma.

Eligible patients undergoing liver resection in the Prince of Wales Hospital will be recruited and randomized into 2 study arms comparing the effect of Pringle maneuver.

Effect of Vascular Inflow Occlusion in Open Liver Resection for Hepatocellular Carcinoma

Open Liver Resection With or Without Vascular Inflow Occlusion for Hepatocellular Carcinoma: a Randomized Controlled Trial

30-day morbidity after open liver resection, which includes ascites, pleural effusion, wound infection and intra-abdominal collection

post-operative liver failure, post-op mortality, operative blood loss, duration of operation and hospital stay

Overall and disease-free survival at 1, 3, 5-year

Recurrence rate of hepatocellular carcinoma at 1,3,5 year

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Effect of Vascular Inflow Occlusion in Open Liver Resection for Hepatocellular Carcinoma	NCT01759901	Hepatocellular ...	Pringle	18 Years -	Chinese University of Hong Kong
Effect of Vascular Inflow Occlusion in Open Liver Resection for Hepatocellular Carcinoma	NCT01759901	Hepatocellular ...	Pringle	18 Years -	Chinese University of Hong Kong
Effect of Vascular Inflow Occlusion in Open Liver Resection for Hepatocellular Carcinoma	NCT01759901	Hepatocellular ...	Pringle	18 Years -	Chinese University of Hong Kong

Spots Global Cancer Trial Database for pringle

Every month we try and update this database with for pringle cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Spots Global Cancer Trial Database for pringle

Every month we try and update this database with for pringle cancer trials from around the world to help patients and their families find trials that might be right for them. We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Every month we try and update this database with for pringle cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.