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Brief Title: Axitinib For The Treatment Of Advanced Hepatocellular Carcinoma
Official Title: A MULTICENTER, GLOBAL, RANDOMIZED, DOUBLE-BLIND STUDY OF AXITINIB PLUS BEST SUPPORTIVE CARE VERSUS PLACEBO PLUS BEST SUPPORTIVE CARE IN PATIENTS WITH ADVANCED HEPATOCELLULAR CARCINOMA FOLLOWING FAILURE OF ONE PRIOR ANTIANGIOGENIC THERAPY
Study ID: NCT01210495
Brief Summary: The study is designed to demonstrate that axitinib plus best supportive care is superior to placebo plus best supportive care in prolonging survival in patients with advanced hepatocellular carcinoma.
Detailed Description:
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Alta Bates Summit Comprehensive Cancer Center, Berkeley, California, United States
UCSD Medical Center- La Jolla, La Jolla, California, United States
Moores UCSD Cancer Center, La Jolla, California, United States
University of California Irvine Medical Center, Orange, California, United States
UCSD Medical Center- Hillcrest, San Diego, California, United States
Florida Hospital Transplant Center, Liver Unit, Orlando, Florida, United States
Moffitt Cancer Center & Research Institute, Tampa, Florida, United States
University of Michigan, Ann Arbor, Michigan, United States
Nebraska Methodist Hospital, Omaha, Nebraska, United States
Comprehensive Cancer Centers of Nevada, Las Vegas, Nevada, United States
Comprehensive Cancer Centers of Nevada, Las Vegas, Nevada, United States
Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, United States
Penn Presbyterian Medical Center, Philadelphia, Pennsylvania, United States
Universitair Ziekenhuis Gent, Gent, , Belgium
CHC Clinique Saint-Joseph, Liège, , Belgium
The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China
Guangdong General Hospital, Guangzhou, Guangdong, China
Nanjing Bayi Hospital, Nan Jing, Jiangsu, China
Jiang Su Cancer Hospital, Nanjing, Jiangsu, China
Sir Run Run Shaw Hospital of College of Medicine of Zhejiang University, Hangzhou, Zhejiang, China
The PLA 307 Hospital, Beijing, , China
Zhongshan Hospital Fudan University, Shanghai, , China
Centre Hospitalier Universitaire d'Amiens, Amiens, , France
Hopital Saint André, Bordeaux Cedex, , France
CHU Cote de Nacre, Caen, cedex 05, , France
Bichat-Beaujon Service Inter Hospitalier De Cancerologie, Clichy, , France
Hopital De La Croix-Rousse, Lyon Cedex 04, , France
UPCET-CIC Timone, Marseille, , France
CHRU Montpellier-Hopital Saint Eloi - Departement Oncologie Medicale, Montpellier Cedex 05, , France
Hôpital L'Archet Ii, Nice, , France
Hôpital Saint Antoine, Paris, , France
Centre Eugène Marquis, Rennes, , France
CHRU de Purpan., Toulouse Cedex, , France
Medizinische Klinik mit Schwerpunkt, Berlin, , Germany
Universitätsklinikum Bonn, Bonn, , Germany
Klinikum der Ludwig-Maximilians-Universitaet , Campus Grosshadern, München, , Germany
Queen Mary Hospital, Hong Kong, , Hong Kong
Prince of Wales Hospital, Shatin, N.T., , Hong Kong
Semmelweis Egyetem I.sz. Belgyógyászati Klinika, Budapest, , Hungary
Szegedi Tudományegyetem Onkoterápiás Klinika, Szeged, , Hungary
Istituto di Ematologia ed Oncologia Medica, Lorenzo ed Ariosto Seragnoli,, Bologna, , Italy
Policlinico S.Orsola-Malpighi Dipartimento di Ematologia e Scienze Oncologiche "L. E A. Seragnoli", Bologna, , Italy
Ospedale Versilia,Oncologia Medica, Lido Di Camaiore (LU), , Italy
Istituto Scientifico Romagnolo per lo Studio e la cura dei Tumori IRST, Meldola (FC), , Italy
Unita Operativa Oncologia Medica IRCCS Fondazione Salvatore Maugeri, Pavia, , Italy
Policlinico Universitario Agostino Gemelli, Roma, , Italy
Unità Operativa Oncologica Medica, Roma, , Italy
Azienda Ospedaliera Universitaria Senese Policlinico Santa Maria aile Scotte, Siena, , Italy
Aichi Cancer Center Central Hospital, Diagnostic and Interventional Radiology, Nagoya, Aichi, Japan
Chiba University Hospital, Chiba City, Chiba, Japan
Gifu Municipal Hospital, Gifu-shi, Gifu, Japan
Kanazawa University Hospital, Kanazawa, Ishikawa, Japan
Kinki University Hospital, Osaka-Sayama, Osaka, Japan
Shizuoka Cancer Center, Suntou-gun, Shizuoka, Japan
Sasaki Foundation Kyoundo Hospital, Chiyoda-Ku, Tokyo, Japan
Nihon University Itabashi Hospital, Itabashi-Ku, Tokyo, Japan
Yamanashi Prefectural Central Hospital, Kofu-Shi, , Japan
National Cancer Center/ Center for Liver Cancer, Goyang-si, , Korea, Republic of
Samsung Medical Center, Division of Hematology-Oncology, Department of Medicine, Seoul, , Korea, Republic of
Asan Medical Center, Division of Oncology, Department of Internal Medicine, Seoul, , Korea, Republic of
Fakultna nemocnica s poliklinikou F. D. Roosevelta Banska Bystrica, Banska Bystrica, , Slovakia
Narodny onkologicky ustav, Bratislava, , Slovakia
POKO Poprad s.r.o., Poprad, , Slovakia
Nemocnica Poprad, a.s., Poprad, , Slovakia
Changhua Christian Hospital, Changhua, , Taiwan
Chang Gung Medical Foundation - Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, , Taiwan
Taichung Veterans General Hospital, Taichung, , Taiwan
National Cheng Kung University Hospital, Tainan, , Taiwan
Chi-Mei Medical Center LiouYing, Tainan, , Taiwan
National Taiwan University Hospital, Taipei, , Taiwan
Chang Gung Medical Foundation Linkou Branch, Taoyuan, , Taiwan
The Christie NHS Foundation Trust, Withington, Manchester, United Kingdom
Clatterbridge Centre for Oncology NHS Foundation Trust, Liverpool, , United Kingdom
Royal Liverpool and Broadgreen University Hospital, Liverpool, , United Kingdom
Royal Free Hospital, London, , United Kingdom
King's College Hospital NHS Foundation Trust, London, , United Kingdom
Hammersmith Hospital, London, , United Kingdom
Name: Pfizer CT.gov Call Center
Affiliation: Pfizer
Role: STUDY_DIRECTOR