Spots Global Cancer Trial Database for best supportive care
Every month we try and update this database with for best supportive care cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.
The following info and data is provided "as is" to help patients around the globe.
We do not endorse or review these studies in any way.
| Study title | NCT ID | Conditions | Interventions | Eligibility | Organization | Link |
|---|---|---|---|---|---|---|
| Second-line Therapy Versus Supportive Care for Pretreated Advanced Gastric Cancer | NCT00821990 | Advanced Gastri... | Chemotherapy Best supportive... | - 75 Years | Samsung Medical Center | |
| Phase I/II Trial to Investigate BI 836858 in Myelodysplastic Syndromes | NCT02240706 | Myelodysplastic... | Best Supportive... BI 836858 | 18 Years - | Boehringer Ingelheim | |
| Evaluation of Repeated Whole Brain Radiotherapy Versus Best Supportive Care for Multiple Brain Metastases. | NCT03288272 | Brain Metastasa... | Whole Brain Rad... Best Supportive... | 18 Years - | Technical University of Munich | |
| 177Lu-PSMA-617 vs. Androgen Receptor-directed Therapy in the Treatment of Progressive Metastatic Castrate Resistant Prostate Cancer | NCT04689828 | Prostatic Neopl... | 177Lu-PSMA-617 68Ga-PSMA-11 ARDT Best supportive... | 18 Years - | Novartis | |
| Treatment of Locally Advanced or Metastatic Transitional Cell Carcinoma With Cabazitaxel | NCT01668459 | Transitional Ce... | Cabazitaxel Best Supportive... | 18 Years - | University Hospital Birmingham NHS Foundation Trust | |
| Maintenance Gemcitabine in the Chinese Advanced Lung Cancer | NCT01336192 | Non Small Cell ... | Gemcitabine Best supportive... | 18 Years - 80 Years | Tongji University | |
| Efficacy and Safety of Lanreotide Autogel/ Depot 120 mg vs. Placebo in Subjects With Lung Neuroendocrine Tumours | NCT02683941 | Neuroendocrine ... | Lanreotide (Aut... Placebo Best Supportive... | 18 Years - | Ipsen | |
| Study of Pembrolizumab (MK-3475) vs. Best Supportive Care in Participants With Previously Systemically Treated Advanced Hepatocellular Carcinoma (MK-3475-240/KEYNOTE-240) | NCT02702401 | Hepatocellular ... | Pembrolizumab Placebo Best Supportive... | 18 Years - | Merck Sharp & Dohme LLC | |
| A Phase II Study of AAA617 Alone and AAA617 in Combination With ARPI in Patients With PSMA PET Scan Positive CRPC | NCT05849298 | Prostatic Neopl... | AAA617 AAA517 Piflufolastat F... ARPI ADT Best supportive... | 18 Years - | Novartis | |
| Phase II Study of Best Support Care (BSC) Plus ZD6474(Vandetanib) in Patients With Inoperable Hepatocellular Carcinoma (HCC) | NCT00508001 | Carcinoma, Hepa... | Vandetanib Vandetanib Best Supportive... | 20 Years - | Sanofi | |
| A Phase II Study of AAA617 Alone and AAA617 in Combination With ARPI in Patients With PSMA PET Scan Positive CRPC | NCT05849298 | Prostatic Neopl... | AAA617 AAA517 Piflufolastat F... ARPI ADT Best supportive... | 18 Years - | Novartis | |
| Sorafenib in Liver Function Impaired Advanced Hepatocellular Carcinoma | NCT01932385 | Liver Cancer | Sorafenib Best Supportive... | 18 Years - 80 Years | Qingdao Central Hospital | |
| Standard Palliative Care Versus Standard Palliative Care Plus Polychemotherapy in Metastasized Malignant Melanoma | NCT00226473 | Metastatic Mela... | Cisplatin, Vind... | 18 Years - 75 Years | Dermatologic Cooperative Oncology Group | |
| A Study to Evaluate the Efficacy and Safety of CNTO328 Plus Best Supportive Care in Multicentric Castleman's Disease | NCT01024036 | Multicentric Ca... | Siltuximab Placebo Best Supportive... | 18 Years - | Janssen Research & Development, LLC | |
| A Phase 2 Study of CRLX101(NLG207) in Patients With Advanced Non-Small Cell Lung Cancer | NCT01380769 | Non-Small Cell ... | CRLX101 Best Supportive... | 18 Years - | Lumos Pharma | |
| Efficacy of 5-Aza for Post-Remission Therapy of Acute Myeloid Leukemia (AML) in Elderly Patients | NCT05188326 | Acute Myeloid L... | Vidaza 100 mill... Best Supportive... | 61 Years - | Associazione Qol-one | |
| Evaluating Panitumumab (ABX-EGF) Plus Best Supportive Care Versus Best Supportive Care in Patients With Metastatic Colorectal Cancer | NCT00113763 | Colorectal Canc... Metastases | Best supportive... Panitumumab | 18 Years - | Amgen | |
| Morphotek Investigation in Colorectal Cancer: Research of MORAb-004 (MICRO) | NCT01507545 | Metastatic Colo... Colorectal Canc... | MORAb-004 Placebo Best supportive... | 18 Years - | Morphotek | |
| Physical Activity and Functioning in Palliative Cancer Patients - a Clinical Randomised Trial | NCT00397774 | Cancer | Physical exerci... best supportive... | - | Norwegian University of Science and Technology | |
| Efficacy of Pazopanib in Gastrointestinal Stromal Tumors (GIST) | NCT01323400 | GIST | Pazopanib Best supportive... | 18 Years - 90 Years | Centre Leon Berard | |
| Study of S-1 Plus DC-CIK for Patients With Unresectable Locally Advanced Pancreatic Cancer | NCT01781520 | Pancreatic Canc... | DC-CIK Treatmen... S1 Best supportive... | 18 Years - | Capital Medical University | |
| Pemetrexed and Best Supportive Care Versus Placebo and Best Supportive Care in Non-Small Cell Lung Cancer (NSCLC) | NCT00102804 | Non-Small Cell ... | Pemetrexed Placebo Best Supportive... | 18 Years - | Eli Lilly and Company | |
| Phase I/II Trial to Investigate BI 836858 in Myelodysplastic Syndromes | NCT02240706 | Myelodysplastic... | Best Supportive... BI 836858 | 18 Years - | Boehringer Ingelheim | |
| A Study of Carfilzomib vs Best Supportive Care in Subjects With Relapsed and Refractory Multiple Myeloma | NCT01302392 | Multiple Myelom... | Carfilzomib Best Supportive... | 18 Years - | Amgen | |
| A Study to Evaluate Neoadjuvant Sonidegib Followed by Surgery or Imiquimod in the Management of Basal Cell Carcinoma | NCT03534947 | Basal Cell Carc... Basal Cell Carc... Skin Cancer Invasive Carcin... | Sonidegib Imiquimod Surgery Best supportive... | 18 Years - | Melanoma Institute Australia | |
| A Study To Evaluate The Efficacy And Safety of The Investigational Drug PF-03446962 (A Monoclonal Antibody With Antiangiogenic Features) In Combination With Best Supportive Care Versus Placebo Plus Best Supportive Care In Patients Affected By Recurrent Liver Cancer | NCT01911273 | Carcinoma, Hepa... | PF-03446962 Best Supportive... Placebo Best Supportive... | 18 Years - | Pfizer | |
| Phase II Study of Best Support Care (BSC) Plus ZD6474(Vandetanib) in Patients With Inoperable Hepatocellular Carcinoma (HCC) | NCT00508001 | Carcinoma, Hepa... | Vandetanib Vandetanib Best Supportive... | 20 Years - | Sanofi | |
| Comparison of Survival Benefit of Panitumumab With Supportive Care to Best Supportive Care Alone in Patients With Metastatic Colorectal Cancer | NCT01412957 | Metastatic Colo... | Best Supportive... Panitumumab | 18 Years - | Amgen | |
| WHOle Brain Irradiation or STEreotactic Radiosurgery for Five or More Brain Metastases (WHOBI-STER) | NCT04891471 | Neurocognitive ... Quality of Life Activities of D... | Stereotactic Ra... Whole Brain Irr... | 18 Years - | Mediterranean Institute of Oncology | |
| A Study Evaluating [177Lu]Lu-PSMA-617 vs. a Change of Androgen Receptor-directed Therapy in Taxane Treatment Naive Chinese Male Patients With Progressive Metastatic Castrate Resistant Prostate Cancer | NCT05658003 | Metastatic Cast... | [177Lu]Lu-PSMA-... ARDT [68Ga]Ga-PSMA-1... Best supportive... | 18 Years - | Novartis | |
| A Study of Induction and Maintenance Treatment of Advanced Non-squamous Non-Small Cell Lung Cancer | NCT00789373 | Non-Small Cell ... | Pemetrexed Cisplatin Placebo Pemetrexed Best Supportive... | 18 Years - | Eli Lilly and Company | |
| Axitinib For The Treatment Of Advanced Hepatocellular Carcinoma | NCT01210495 | Hepatocellular ... | Axitinib (AG-01... Best Supportive... Placebo Best Supportive... | 18 Years - | Pfizer | |
| Study of Pembrolizumab (MK-3475) vs. Best Supportive Care in Participants With Previously Systemically Treated Advanced Hepatocellular Carcinoma (MK-3475-240/KEYNOTE-240) | NCT02702401 | Hepatocellular ... | Pembrolizumab Placebo Best Supportive... | 18 Years - | Merck Sharp & Dohme LLC | |
| The PALSUR-study: Palliative Care Versus Surgery in High-grade Glioma Patients (ENCRAM 2203) | NCT06146738 | Glioblastoma Glioblastoma Mu... Glioblastoma, I... Glioblastoma Mu... | Palliative Care Tumor biopsy Tumor resection | 18 Years - 90 Years | Erasmus Medical Center | |
| Maintenance Gemcitabine in the Chinese Advanced Lung Cancer | NCT01336192 | Non Small Cell ... | Gemcitabine Best supportive... | 18 Years - 80 Years | Tongji University | |
| The PALSUR-study: Palliative Care Versus Surgery in High-grade Glioma Patients (ENCRAM 2203) | NCT06146738 | Glioblastoma Glioblastoma Mu... Glioblastoma, I... Glioblastoma Mu... | Palliative Care Tumor biopsy Tumor resection | 18 Years - 90 Years | Erasmus Medical Center | |
| 177Lu-PSMA-617 vs. Androgen Receptor-directed Therapy in the Treatment of Progressive Metastatic Castrate Resistant Prostate Cancer | NCT04689828 | Prostatic Neopl... | 177Lu-PSMA-617 68Ga-PSMA-11 ARDT Best supportive... | 18 Years - | Novartis | |
| Randomized Study Of CP-675,206 or Best Supportive Care Immediately After Platinum-Based Therapy For Non-Small Cell Lung Cancer (NSCLC) | NCT00312975 | Carcinoma, Non-... | CP-675,206 best supportive... | 18 Years - | AstraZeneca | |
| Efficacy of Oral Azacitidine Plus Best Supportive Care as Maintenance Therapy in Subjects With Acute Myeloid Leukemia (AML) in Complete Remission | NCT01757535 | Leukemia, Myelo... | Oral Azacitidin... Placebo | 55 Years - | Celgene | |
| Comparison of Survival Benefit of Panitumumab With Supportive Care to Best Supportive Care Alone in Patients With Metastatic Colorectal Cancer | NCT01412957 | Metastatic Colo... | Best Supportive... Panitumumab | 18 Years - | Amgen | |
| Study of Palliative Radiotherapy for Symptomatic Hepatocellular Carcinoma and Liver Metastases | NCT02511522 | Hepatocellular ... Liver Metastase... | Best Supportive... Palliative Radi... | 18 Years - | Canadian Cancer Trials Group | |
| Masitinib in Severe Indolent or Smoldering Systemic Mastocytosis Unresponsive to Optimal Symptomatic Treatment | NCT04333108 | Indolent System... | Masitinib Placebo Best Supportive... | 18 Years - 75 Years | AB Science | |
| Sorafenib in First-line Treatment of Advanced B Child Hepatocellular Carcinoma | NCT01405573 | Advanced Adult ... | Best Supportive... sorafenib | 18 Years - | National Cancer Institute, Naples | |
| Study of Palliative Radiotherapy for Symptomatic Hepatocellular Carcinoma and Liver Metastases | NCT02511522 | Hepatocellular ... Liver Metastase... | Best Supportive... Palliative Radi... | 18 Years - | Canadian Cancer Trials Group | |
| A Study Comparing of Two Different Chemotherapy Regimens, in Patients With Advanced Non-Squamous Non-Small Cell Lung Cancer | NCT00606021 | Non Small Cell ... | pemetrexed Best Supportive... | 18 Years - | Eli Lilly and Company | |
| Benefit of Chemotherapy Over Best Supportive Care in Metastatic and Squamous Cell-type Esophageal Cancer. | NCT01248299 | Squamous Cell C... | FU-CDDP LV5FU2-CDDP FOLFOX TPF Best Supportive... | 18 Years - | Centre Oscar Lambret | |
| The RECSUR-study: Resection Versus Best Oncological Treatment for Recurrent Glioblastoma (ENCRAM 2302) | NCT06283927 | Glioblastoma Glioblastoma Mu... Glioblastoma, I... Glioblastoma Mu... Glioblastoma Mu... Recurrent Gliob... Astrocytoma, Ma... Astrocytoma of ... | Re-resection Temozolomide Lomustine Re-irradiation Experimental th... Best supportive... | 18 Years - 90 Years | Erasmus Medical Center | |
| Maintenance Therapy With Autologous Cytokine-induced Killer Cells for Small Cell Lung Cancer | NCT01592422 | Small Cell Lung... | Autologous cyto... Best Supportive... | 18 Years - 75 Years | People's Hospital of Guangxi | |
| A Study to Evaluate the Efficacy and Safety of CNTO328 Plus Best Supportive Care in Multicentric Castleman's Disease | NCT01024036 | Multicentric Ca... | Siltuximab Placebo Best Supportive... | 18 Years - | Janssen Research & Development, LLC | |
| Study of Pembrolizumab (MK-3475) vs. Best Supportive Care in Participants With Previously Systemically Treated Advanced Hepatocellular Carcinoma (MK-3475-240/KEYNOTE-240) | NCT02702401 | Hepatocellular ... | Pembrolizumab Placebo Best Supportive... | 18 Years - | Merck Sharp & Dohme LLC | |
| Maintenance Tislelizumab + Capecitabine to Treat Metastatic Colorectal Cancer | NCT05360277 | Metastatic Colo... | Tislelizumab + ... Best supportive... | 18 Years - 80 Years | Sun Yat-sen University | |
| Randomized Study Of CP-675,206 or Best Supportive Care Immediately After Platinum-Based Therapy For Non-Small Cell Lung Cancer (NSCLC) | NCT00312975 | Carcinoma, Non-... | CP-675,206 best supportive... | 18 Years - | AstraZeneca | |
| Evaluation of Repeated Whole Brain Radiotherapy Versus Best Supportive Care for Multiple Brain Metastases. | NCT03288272 | Brain Metastasa... | Whole Brain Rad... Best Supportive... | 18 Years - | Technical University of Munich | |
| Geriatric Assessment Directed Trial to Evaluate Gemcitabine +/- Nab-paclitaxel in Elderly Pancreatic Cancer Patients | NCT02812992 | Adenocarcinoma ... | Nab-paclitaxel Gemcitabine Best Supportive... | 70 Years - | AIO-Studien-gGmbH | |
| Durvalumab and Tremelimumab and Best Supportive Care vs Best Supportive Care in Patients With Advanced Colorectal Cancer | NCT02870920 | Colorectal Canc... | Tremelimumab Durvalumab Best Supportive... | 18 Years - | Canadian Cancer Trials Group | |
| The PALSUR-study: Palliative Care Versus Surgery in High-grade Glioma Patients (ENCRAM 2203) | NCT06146738 | Glioblastoma Glioblastoma Mu... Glioblastoma, I... Glioblastoma Mu... | Palliative Care Tumor biopsy Tumor resection | 18 Years - 90 Years | Erasmus Medical Center | |
| Biliary Drainage Plus HAIC in Locally Advanced pCCA | NCT05024513 | Perihilar Chola... | oxaliplatin and... Biliary Drainag... Best Supportive... External biliar... | 18 Years - 80 Years | Peking University | |
| Phase II Study of Best Support Care (BSC) Plus ZD6474(Vandetanib) in Patients With Inoperable Hepatocellular Carcinoma (HCC) | NCT00508001 | Carcinoma, Hepa... | Vandetanib Vandetanib Best Supportive... | 20 Years - | Sanofi | |
| Study of Palliative Radiotherapy for Symptomatic Hepatocellular Carcinoma and Liver Metastases | NCT02511522 | Hepatocellular ... Liver Metastase... | Best Supportive... Palliative Radi... | 18 Years - | Canadian Cancer Trials Group | |
| Pemetrexed and Best Supportive Care Versus Placebo and Best Supportive Care in Non-Small Cell Lung Cancer (NSCLC) | NCT00102804 | Non-Small Cell ... | Pemetrexed Placebo Best Supportive... | 18 Years - | Eli Lilly and Company | |
| Efficacy of Oral Azacitidine Plus Best Supportive Care as Maintenance Therapy in Subjects With Acute Myeloid Leukemia (AML) in Complete Remission | NCT01757535 | Leukemia, Myelo... | Oral Azacitidin... Placebo | 55 Years - | Celgene | |
| Randomized Study Of CP-675,206 or Best Supportive Care Immediately After Platinum-Based Therapy For Non-Small Cell Lung Cancer (NSCLC) | NCT00312975 | Carcinoma, Non-... | CP-675,206 best supportive... | 18 Years - | AstraZeneca | |
| A Study of Nivolumab in Advanced Non-Small Cell Lung Cancer (NSCLC) | NCT02574078 | Non-Small Cell ... | Nivolumab Bevacizumab Pemetrexed Best Supportive... nab-Paclitaxel Paclitaxel Docetaxel Gemcitabine Erlotinib Crizotinib Carboplatin | 18 Years - | Bristol-Myers Squibb | |
| Ph 3 ADI-PEG 20 Versus Placebo in Subjects With Advanced Hepatocellular Carcinoma Who Have Failed Prior Systemic Therapy | NCT01287585 | Hepatocellular ... | ADI-PEG 20 (arg... Placebo Best Supportive... | 18 Years - | Polaris Group | |
| Axitinib For The Treatment Of Advanced Hepatocellular Carcinoma | NCT01210495 | Hepatocellular ... | Axitinib (AG-01... Best Supportive... Placebo Best Supportive... | 18 Years - | Pfizer | |
| Geriatric Assessment Directed Trial to Evaluate Gemcitabine +/- Nab-paclitaxel in Elderly Pancreatic Cancer Patients | NCT02812992 | Adenocarcinoma ... | Nab-paclitaxel Gemcitabine Best Supportive... | 70 Years - | AIO-Studien-gGmbH | |
| Second-line Therapy Versus Supportive Care for Pretreated Advanced Gastric Cancer | NCT00821990 | Advanced Gastri... | Chemotherapy Best supportive... | - 75 Years | Samsung Medical Center | |
| Masitinib in Severe Indolent or Smoldering Systemic Mastocytosis | NCT00814073 | Indolent System... | Masitinib Placebo Best Supportive... | 18 Years - 75 Years | AB Science | |
| Multicentre Placebo-controlled Double-blinded Phase II Study of Lenvatinib Efficacy in Patients With Locally Advanced or Metastatic GIST (Gastrointestinal Stromal Tumor) After Imatinib/Sunitinib Failure | NCT04193553 | Gastro Intestin... | Lenvatinib Placebo Best supportive... | 18 Years - | Centre Leon Berard | |
| Ph 3 ADI-PEG 20 Versus Placebo in Subjects With Advanced Hepatocellular Carcinoma Who Have Failed Prior Systemic Therapy | NCT01287585 | Hepatocellular ... | ADI-PEG 20 (arg... Placebo Best Supportive... | 18 Years - | Polaris Group | |
| Maintenance Therapy With Autologous Cytokine-induced Killer Cells for Small Cell Lung Cancer | NCT01592422 | Small Cell Lung... | Autologous cyto... Best Supportive... | 18 Years - 75 Years | People's Hospital of Guangxi | |
| Phase II Study of NGR-hTNF Versus Placebo as Maintenance Treatment in Patients With Advanced MPM | NCT01358084 | Advanced Malign... | NGR-hTNF Placebo Best Supportive... | 18 Years - | AGC Biologics S.p.A. |
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