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Spots Global Cancer Trial Database for A Dose-escalation Study of the Safety and Pharmacology of DAN-222 in Subjects With Metastatic Breast Cancer

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Trial Identification

Brief Title: A Dose-escalation Study of the Safety and Pharmacology of DAN-222 in Subjects With Metastatic Breast Cancer

Official Title: A Dose-escalation Study of the Safety and Pharmacology of DAN-222 in Subjects With Metastatic Breast Cancer

Study ID: NCT05261269

Interventions

DAN-222
Niraparib

Study Description

Brief Summary: This was an open-label, multicenter, dose-escalation study designed to assess the safety, tolerability, and PK of IV administered DAN-222 followed by a dose-escalation of DAN-222 in combination with niraparib: * Part A is dose escalation of single agent DAN-222 * Part B is dose escalation of DAN-222 in combination with niraparib

Detailed Description:

Keywords

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: FEMALE

Healthy Volunteers: No

Locations

UC San Diego Moores Cancer Center, La Jolla, California, United States

UCLA - Parkside Cancer Center, Santa Monica, California, United States

H Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, United States

University of Michigan, Ann Arbor, Michigan, United States

Saint Luke's Cancer Institute, Jackson, Missouri, United States

Icahn School of Medicine at Mount Sinai, New York, New York, United States

The University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States

Magee Women's Hospital, Pittsburgh, Pennsylvania, United States

Sarah Cannon Research Institute/Tennessee Oncology, Nashville, Tennessee, United States

Contact Details

Useful links and downloads for this trial

Clinicaltrials.gov

Google Search Results

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