Spots Global Cancer Trial Database for Special Care Patterns for Elderly HNSCC Patients Undergoing Radiotherapy
The following info and data is provided "as is" to help patients around the globe.
We do not endorse or review these studies in any way.
Trial Identification
Brief Title: Special Care Patterns for Elderly HNSCC Patients Undergoing Radiotherapy
Official Title: Special Care Patterns for Elderly HNSCC Patients Undergoing Radiotherapy
Study ID: NCT05337631
Interventions
Study Description
Brief Summary: The number of elderly head-and-neck squamous cell carcinoma (HNSCC) patients is increasing; however, the evidence regarding the ideal treatment for this often vulnerable and frail patient cohort is limited. Although the benefit of concomitant chemotherapy has been reported to decrease in elderly HNSCC patients based on the MACH-NC meta-analysis, it remains unknown whether state-of-the art radiotherapy techniques such as intensity-modulated radiotherapy (IMRT), modern supportive treatments and alternative chemotherapy fractionation (e.g., cisplatin weekly) may have altered this observation. The objective of this retrospective multinational multicenter study is to determine the oncological outcomes of elderly patients (≥65 years) with locally advanced HNSCCs undergoing definitive (chemo-)radiation and to investigate the influence of concomitant chemotherapy on overall survival and progression-free survival after adjusting for potential confounder variables such as age, performance status and comorbidity burden.
Detailed Description:
Eligibility
Minimum Age: 65 Years
Eligible Ages: OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States
Department of Radiation Oncology, Icahn School of Medicine at Mount Sinai, New York, New York, United States
Department of Radiation Oncology, Case Western Reserve University, Cleveland, Ohio, United States
Division of Radiation Oncology, The Ohio State University Wexner, Columbus, Ohio, United States
Radiation Oncology Department, German Oncology Center, Limassol, , Cyprus
Department of Radiooncology and Radiotherapy, Charité-Universitätsmedizin Berlin, Berlin, , Germany
Department of Radiation Oncology, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, , Germany
Department of Radiotherapy and Oncology, Goethe-University Frankfurt am Main, Frankfurt, , Germany
Department of Radiation Oncology, University Hospital Schleswig-Holstein, Kiel, , Germany
Department of Radiation Oncology, University Medical Center Leipzig, Leipzig, , Germany
Department of Radiation Oncology, University Medical Center Mainz, Mainz, , Germany
Department of Radiation Oncology, University Hospital, LMU Munich, Munich, , Germany
Department of Radiation Oncology, University Hospital Würzburg, Würzburg, , Germany
Department of Radiation Oncology, University Hospital Zurich (USZ), University of Zurich (UZH), Zürich, , Switzerland
Contact Details
Name: Nils H. Nicolay, MD, PhD
Affiliation: Department of Radiation Oncology, Medical Center - University of Freiburg
Role: PRINCIPAL_INVESTIGATOR
Take Control of Your Skin and Body Changes Today.
Try out Spots for free, set up only takes 2 mins.
Join others from around the world:
