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Spots Global Cancer Trial Database for AKT Inhibitor in Oestrogen Positive Breast Cancer

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Trial Identification

Brief Title: AKT Inhibitor in Oestrogen Positive Breast Cancer

Official Title: The Short Term Effects of an AKT Inhibitor (AZD5363) on Biomarkers of the AKT Pathway and Anti-tumour Activity in a Breast Cancer Paired Biopsy Study

Study ID: NCT02077569

Interventions

AZD5363

Study Description

Brief Summary: To compare the effect of four and a half days treatment of a range of doses of AZD5363 on selected markers of the AKT pathway and anti-proliferation compared with placebo in oestrogen receptor positive breast cancers. To assess the tolerability of four and a half days treatment of AZD5363.

Detailed Description: The principal research questions to be addressed are whether (or not) AZD5363 is "hitting its therapeutic target" sufficiently and to the extent that is required to produce efficacy in pre-clinical experiments. The primary endpoint markers have been selected to determine this. Reductions in markers of the AKT pathway and increases in markers of anti-proliferation will characterise the degree of biological activity arising from the inhibition of AKT across a range of doses of AZD5363.

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: FEMALE

Healthy Volunteers: No

Locations

Royal Derby Hospital, Derby, Derbyshire, United Kingdom

Plymouth Hospitals NHS Trust, Derriford, Plymouth, Devon, United Kingdom

Royal Bournemouth Hospital, Bournemouth, Dorset, United Kingdom

Poole Hospital NHS Foundation Trust, Poole, Dorset, United Kingdom

Leicester Royal Infirmary, Leicester, Leicestershire, United Kingdom

Western General Hospital, Edinburgh, Lothian, United Kingdom

Royal Liverpool University Hospital, Liverpool, Merseyside, United Kingdom

Kingsmill Hospital, Sutton-in-Ashfield, Nottinghamshire, United Kingdom

Sheffield Cancer Research Centre, Sheffield, South Yorkshire, United Kingdom

University Hospital Birmingahm, Birmingham, West Midlands, United Kingdom

Leeds St James Institue of Oncology, Leeds, West Yorkshire, United Kingdom

Contact Details

Name: John FR Robertson, MD

Affiliation: University of Nottingham

Role: STUDY_CHAIR

Useful links and downloads for this trial

Clinicaltrials.gov

Google Search Results

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