Spots Global Cancer Trial Database for Effect of Ultrasound Combined With Microbubbles on Blood Perfusion in Invasive Breast Cancer

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Trial Identification

Brief Title: Effect of Ultrasound Combined With Microbubbles on Blood Perfusion in Invasive Breast Cancer

Official Title: Effect of Ultrasound Combined With Microbubbles on Blood Perfusion in Invasive Breast Cancer

Study ID: NCT06158217

Conditions

Invasive Breast Cancer

Cavitation

Perfusion

Interventions

ultrasound combined with microbubbles

Study Description

Brief Summary: Blood perfusion insufficiency and hypoxia are the main causes of drug resistance to chemotherapy in breast cancer. Increasing blood perfusion can improve drug delivery. The cavitation effect of ultrasound-stimulated microbubbles (USMBs) is known to enhance tumor blood perfusion, so we conducted a prospective human study to investigate the effects of USMBs on hemoperfusion in invasive breast cancer (IBC).

Detailed Description: patients with IBC were selected from the breast surgery department of our hospital. To induce an enhanced perfusion effect, IBC tumors were treated with SonoVue® microbubbles (MBs) stimulated by ultrasound, with a mechanical index (MI) of 0.2-0.3; 1 mL of SonoVue® MBs were injected at 3.5-min intervals three times for a USMB treatment lasting 10 min. The contrast-enhanced ultrasound (CEUS) parameters peak intensity (PI), area under the curve (AUC), and perfusion area were used to evaluate the changes in blood perfusion.